CAPS_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAPS_DROME
• UniProt AC: Q9NHE5
• Protein Name: Calcium-dependent secretion activator
• Gene Name: Cadps {ECO:0000312|FlyBase:FBgn0053653}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1447
• Subcellular Localization: Cytoplasmic vesicle membrane . Cell junction, synapse . Membrane-associated to vesicles. Restricted to all classes of presynaptic termini independent of the ratio of vesicular content (DCVs versus SVs). Found in all identified classes of peripheral a
• Protein Description: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. However, it probably also participates in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering..
• Protein Sequence: MIDPSSSEEEGEDDAVPNVSSKGRLTNTTKGTSAVSIIGGSAGSVVGSNIPVSGSNTDLIGNQRQSNISSICNRNDVGNISVAALGSTSNKIEQICGNRADTGNLEVPSNGIPSGISQETLNQSVGSSRANSLPRPLSPSPSLTSEKHETAEPHGKHEREEEERKRRIQLYVFISRCISYPFNAKQPTDMTKRQTKISKQQLEIITQRFQAFLKGETQIMADEAFQNAVQSYHDVFLKSERVLKMVQSGASSQHDFREVFRNNIEKRVRSLPEIDGLSKETVLTSWMAKFDIILKGTGEEDSKRPSRMQQSLNSELILSKEQLYDMFQQILLVKKFEHQILFNALMLDSADEQAAAIRRELDGRMQRVGEMEKNRKLMPKFVLKEMESLYVEELKSSINLLMANLESLPVSKGNMDSKYGLQKLKRYNHSTPSFLKLILRSHGSLSKLEGDSEDGSTQLTKLDVVLTFQLEVIVMEVENGEKLQTDQAEASKPMWDTQGDFTTTHPLPVVKVKLYTENPGMLALEDKELGKVTLKPTPLSSKSPEWHRMIVPKNLPDQDIRIKIACRLDKPLNMKHCGYLYAIGKSVWKKWKRRYFVLVQVSQYTFAMCSYKEKKSEPSEMMQLDGYTVDYIEAASANLMFGIDLNGGRYFFNAVREGDSISFACDDENECSLWVMAMYRATGQSHKPTPPITQDKNSAMSKIQGDADKARKHGMEDFISTDPCTFDHATLFKTLQNLTLEYRLNDPYASLGWFSPGQVFVLDEYCARYGVRGCYRHLCYLSDLLDRAEKQHMIDPTLIHYSFAFCASHVHGNRPDGVGSITHEEKEKFSEIKERLRQLLEFQITNFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPPEEVRQMIKKSLETAALVNYTRLSNKAKIDEDLRGDVIVPAPKKLEDLIHLAELCVDLLQQNEEHYGEAFAWFSDLLVEHAEIFWSLFAVDMDRVLSEQAPDTWDSFPLFQILNDYLRTDDNLRNGRFHQHLRDTFAPLVVRYVDLMESSIAQSIHKGFEKERWESKGINAALNPAALNNAAQALNTAALNPSMILCGKKDQVNFYVPKLPKQSNSTAANDEMRNGCATSEDLFWKLDALQSFIRDLHWPDAEFRQHLEQRLKMMAVDMIEQCIQRTDSSFQSWLKKNIAFISTDYILPSEMCAMVNVILDAKNQSFKLTTIDGIDLYKFHAKIDDQIDKANVAMTQGLSGKLMSVLESTLSKLARYDEGSLIGSILSFTNVSSSGKDLGQGYVNFFRNNMDQVRGKIADDLWTLHFFEQWYSQQINMLCNWLSERVDHALHYAQVASISHIIKKIYSDFELQGVLEDKLNSKAYQAVAQRMATEEATCALTMPDACEDEPCDEIREGEEEDNGDESTSNIPRGLPKPKVAAAQAAAVTNVVAGRVGNLLGKGIGGLSSKLGSGSWF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MIDPSSSEEEGE ---CCCCCCCCCCCC	42.63	27794539
6	Phosphorylation	--MIDPSSSEEEGED --CCCCCCCCCCCCC	47.35	27794539
7	Phosphorylation	-MIDPSSSEEEGEDD -CCCCCCCCCCCCCC	54.05	27794539
388	Phosphorylation	FVLKEMESLYVEELK HHHHHHHHHHHHHHH	24.56	27794539
433	Phosphorylation	RYNHSTPSFLKLILR HCCCCCHHHHHHHHH	43.21	19429919
452	Phosphorylation	LSKLEGDSEDGSTQL HHHCCCCCCCCCCCC	48.74	27794539
888	Ubiquitination	PEEVRQMIKKSLETA HHHHHHHHHHHHHHH	3.73	31113955
903	Ubiquitination	ALVNYTRLSNKAKID HHHHHHHHCCCCCCC	5.22	31113955
907	Ubiquitination	YTRLSNKAKIDEDLR HHHHCCCCCCCHHHC	20.49	31113955
908	Ubiquitination	TRLSNKAKIDEDLRG HHHCCCCCCCHHHCC	52.91	31113955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAPS_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAPS_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAPS_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of CAPS_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.