CAPR1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAPR1_RAT
• UniProt AC: Q5M9G3
• Protein Name: Caprin-1
• Gene Name: Caprin1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 707
• Subcellular Localization: Cytoplasm, cytosol. Cell projection, dendrite . Associated with RNA granules.
• Protein Description: May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs..
• Protein Sequence: MPSATSHSGSGSKSSGPPPPSGSSGSEAAAGAAAPASQHPATGTGAVQTEAMKQILGVIDKKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMALSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLGDDDVRTDLKQGLSGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHASIHLWDLLEGKEKPVCGTTYKALKEIVERVFQSNYFDSTHNHQNGLCEEEEAASAPIVEDQVAEAEPEPTEEYTEQSEVESTEYVNRQFMAETQFSSGEKEQVDEWAVETVEVVNSLQQQPQAASPSVPEPHSLTPVAQSDPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPTQNMDMPQLVCPQVHSESRLAQSNQVPVQPEATQVPLVSSTSEGYTASQPLYQPSHAAEQRPQKEPIDQIQATISLNTEQTTASSSLPAASQPQVFQAGASKPLHSSGINVNAAPFQSMQTVFNMNAPVPPVNEPETLKQQSQYQASYNQSFSSQPHQVEQTELQQDQLQTVVGTYHGSQDQPHQVPGNHQQPPQQSTGFPRSSQPYYNSRGVSRGGSRGARGLMNGYRGPANGFRGGYDGYRSSFSNTPNSGYTQSQFNAPRDYSGYQRDGYQQNFKRGSGQSGPRGAPRGRGGPPRPNRGMPQMNTQQVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MPSATSHSG ------CCCCCCCCC	32.44	-
5	Phosphorylation	---MPSATSHSGSGS ---CCCCCCCCCCCC	31.17	26022182
10	Phosphorylation	SATSHSGSGSKSSGP CCCCCCCCCCCCCCC	42.80	26022182
14	Phosphorylation	HSGSGSKSSGPPPPS CCCCCCCCCCCCCCC	42.07	27097102
15	Phosphorylation	SGSGSKSSGPPPPSG CCCCCCCCCCCCCCC	60.08	27097102
21	Phosphorylation	SSGPPPPSGSSGSEA CCCCCCCCCCCHHHH	58.02	27097102
23	Phosphorylation	GPPPPSGSSGSEAAA CCCCCCCCCHHHHHH	35.54	27097102
24	Phosphorylation	PPPPSGSSGSEAAAG CCCCCCCCHHHHHHH	50.27	27097102
26	Phosphorylation	PPSGSSGSEAAAGAA CCCCCCHHHHHHHCC	26.47	27097102
61	Acetylation	QILGVIDKKLRNLEK HHHHHHHHHHHHHHH	42.45	22902405
72	Acetylation	NLEKKKGKLDDYQER HHHHHCCCHHHHHHH	58.59	22902405
95	Phosphorylation	QDQLDAVSKYQEVTN HHHHHHHHHHHHHHH	27.63	30181290
108	Ubiquitination	TNNLEFAKELQRSFM HHHHHHHHHHHHHHH	65.36	-
113	Phosphorylation	FAKELQRSFMALSQD HHHHHHHHHHHHHHH	13.35	28432305
118	Phosphorylation	QRSFMALSQDIQKTI HHHHHHHHHHHHHHH	19.10	27097102
163	Methylation	KLGDDDVRTDLKQGL HHCCCHHHHHHHHCC	29.53	-
301	Phosphorylation	NRQFMAETQFSSGEK CHHHHHEECCCCCCC	25.94	27097102
304	Phosphorylation	FMAETQFSSGEKEQV HHHEECCCCCCCHHH	27.84	27097102
305	Phosphorylation	MAETQFSSGEKEQVD HHEECCCCCCCHHHC	52.86	27097102
324	Phosphorylation	ETVEVVNSLQQQPQA HHHHHHHHHHHCCCC	18.88	28432305
333	Phosphorylation	QQQPQAASPSVPEPH HHCCCCCCCCCCCCC	22.26	22668510
335	Phosphorylation	QPQAASPSVPEPHSL CCCCCCCCCCCCCCC	48.05	28432305
341	Phosphorylation	PSVPEPHSLTPVAQS CCCCCCCCCCCCCCC	44.66	28432305
343	Phosphorylation	VPEPHSLTPVAQSDP CCCCCCCCCCCCCCH	20.80	28432305
624	Methylation	RGLMNGYRGPANGFR HHHCCCCCCCCCCCC	46.12	-
631	Methylation	RGPANGFRGGYDGYR CCCCCCCCCCCCCCH	38.74	-
638	Methylation	RGGYDGYRSSFSNTP CCCCCCCHHCCCCCC	31.21	-
639	Phosphorylation	GGYDGYRSSFSNTPN CCCCCCHHCCCCCCC	27.53	27097102
640	Phosphorylation	GYDGYRSSFSNTPNS CCCCCHHCCCCCCCC	24.56	28432305
642	Phosphorylation	DGYRSSFSNTPNSGY CCCHHCCCCCCCCCC	41.56	29779826
644	Phosphorylation	YRSSFSNTPNSGYTQ CHHCCCCCCCCCCCH	23.73	28432305
647	Phosphorylation	SFSNTPNSGYTQSQF CCCCCCCCCCCHHHC	34.09	27097102
649	Phosphorylation	SNTPNSGYTQSQFNA CCCCCCCCCHHHCCC	11.04	25575281
650	Phosphorylation	NTPNSGYTQSQFNAP CCCCCCCCHHHCCCC	25.85	25575281
696	Methylation	GGPPRPNRGMPQMNT CCCCCCCCCCCCCCC	45.53	-
696	Asymmetric dimethylarginine	GGPPRPNRGMPQMNT CCCCCCCCCCCCCCC	45.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAPR1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAPR1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAPR1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CAPR1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.