dbPTM

CAPP2_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CAPP2_ARATH
UniProt AC	Q5GM68
Protein Name	Phosphoenolpyruvate carboxylase 2
Gene Name	PPC2
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	963
Subcellular Localization	Cytoplasm.
Protein Description	Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle..
Protein Sequence	MAARNLEKMASIDAQLRLLAPGKVSEDDKLIEYDALLLDRFLDILQDLHGEDVREFVQECYEVAADYDGNRNTEKLEELGNMLTSLDPGDSIVVTKSFSNMLSLANLAEEVQIAYRRRIKKLKKGDFADEASATTESDIEETLKRLLQLNKTPEEVFDALKNQTVDLVLTAHPTQSVRRSLLQKFGRIRDCLTQLYAKDITPDDKQELDEALQREIQAAFRTDEIRRTPPTPQDEMRAGMSYFHETIWKGVPKFLRRVDTALKNIGINERVPYNAPLIQFSSWMGGDRDGNPRVTPEVTRDVCLLARMMAANLYFSQIEDLMFEMSMWRCNEELRVRAERQRCAKRDAKHYIEFWKQIPANEPYRAILGDVRDKLYNTRERARQLLSSGVSDVPEDAVFTSVDQFLEPLELCYRSLCDCGDRPIADGSLLDFLRQVSTFGLALVKLDIRQESERHSDVLDAITTHLGIGSYKEWSEDKRQEWLLSELSGKRPLFGPDLPKTEEVADVLDTFKVISELPSDSFGAYIISMATAPSDVLAVELLQRECGITDPLRVVPLFEKLADLESAPAAVARLFSIEWYRNRINGKQEVMIGYSDSGKDAGRLSAAWQLYKTQEELVKVAKEYGVKLTMFHGRGGTVGRGGGPTHLAILSQPPDTIHGQLRVTVQGEVIEQSFGEEHLCFRTLQRFTAATLEHGMHPPVSPKPEWRVLMDEMAIIATEEYRSVVFKEPRFVEYFRLATPELEYGRMNIGSRPSKRKPSGGIESLRAIPWIFAWTQTRFHLPVWLGFGGAFKRVIQKDSKNLNMLKEMYNQWPFFRVTIDLVEMVFAKGDPGIAALYDRLLVSEELQPFGEQLRVNYQETRRLLLQVAGHKDILEGDPYLRQRLQLRDPYITTLNVCQAYTLKQIRDPSFHVKVRPHLSKDYMESSPAAELVKLNPKSEYAPGLEDTVILTMKGIAAGMQNTG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	RNLEKMASIDAQLRL CCHHHHHCCCHHHHH	19.94	30291188
231	Phosphorylation	EIRRTPPTPQDEMRA HHCCCCCCCHHHHHH	34.48	23328941
549	Phosphorylation	LQRECGITDPLRVVP HHHHHCCCCCHHHHH	19.49	24243849
701	Phosphorylation	HGMHPPVSPKPEWRV CCCCCCCCCCHHHHH	32.74	23111157
751	Phosphorylation	YGRMNIGSRPSKRKP HCCCCCCCCCCCCCC	36.90	25561503
759	Phosphorylation	RPSKRKPSGGIESLR CCCCCCCCCCHHHHH	53.32	30291188
764	Phosphorylation	KPSGGIESLRAIPWI CCCCCHHHHHHHHHH	22.64	23776212
922	Phosphorylation	RPHLSKDYMESSPAA CCCCCHHHHCCCCHH	13.40	25561503
923	Sulfoxidation	PHLSKDYMESSPAAE CCCCHHHHCCCCHHH	6.05	25693801
926	Phosphorylation	SKDYMESSPAAELVK CHHHHCCCCHHHHHH	12.78	23111157
952	Sulfoxidation	EDTVILTMKGIAAGM CCEEEEEEHHHHHHH	3.16	25693801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CAPP2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CAPP2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CAPP2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CAPP2_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CAPP2_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Site-specific phosphorylation profiling of Arabidopsis proteins bymass spectrometry and peptide chip analysis."; de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C.,Lorkovic Z.J., Barta A., Lecourieux D., Verhounig A., Jonak C.,Hirt H.; J. Proteome Res. 7:2458-2470(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-701, AND MASSSPECTROMETRY.	18433157 [Abstract]