CAP2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAP2_RAT
• UniProt AC: P52481
• Protein Name: Adenylyl cyclase-associated protein 2
• Gene Name: Cap2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 477
• Subcellular Localization: Cell membrane; Peripheral membrane protein.
• Protein Description: May have a regulatory bifunctional role..
• Protein Sequence: MADMLGLMQRLEFAVSRLERLSSGLHEPPGGCGEVNSLSRGIVAPSVEAFDKLINSMVAEFLKNSRVLAGDVETHAEMVHGAFQAQRAFLLMVSQHQQPQENEVAVLLKPISEKIQEIQTFRERNRGSDMFNHLSAVSESIAALGWIAVSPKPGPYVKEMNDAATFYTNRVLRDYKHSDLRHVDWVRSYLKIWSELQAYIKEHHTTGLTWSKTGPVASTASAFSILSSGPGLPPPPPPPPPPGPPPPFENEGGKEEPSPSRSALFAQLNQGEAITKGLRHVTDDKKIYKNPSLRAQGQIRSPTKTRTPSPTSSKSNSPQKHAPVLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCDKSTLQIKGKVNSITVDNCKKFGLVFDHVVGIVEVINSKDIQIQVMGRVPTISINKTEGCHLYLSKDALDCEIVSAKSSEMNVLVPQGDDYREFPIPEQFKTIWDGSKLITEPAEIMA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADMLGLMQ ------CCHHHHHHH	15.77	-
37	Phosphorylation	GGCGEVNSLSRGIVA CCCCHHCCCCCCCCC	32.66	23800682
262	Phosphorylation	EEPSPSRSALFAQLN CCCCCCHHHHHHHHH	33.39	23800682
276	Ubiquitination	NQGEAITKGLRHVTD HHHHHHHCHHCCCCC	50.24	-
288	Phosphorylation	VTDDKKIYKNPSLRA CCCCCCCCCCHHHHC	17.37	-
301	Phosphorylation	RAQGQIRSPTKTRTP HCCCCCCCCCCCCCC	38.25	27097102
303	Phosphorylation	QGQIRSPTKTRTPSP CCCCCCCCCCCCCCC	46.42	30322021
305	Phosphorylation	QIRSPTKTRTPSPTS CCCCCCCCCCCCCCC	42.10	28551015
307	Phosphorylation	RSPTKTRTPSPTSSK CCCCCCCCCCCCCCC	33.09	28551015
309	Phosphorylation	PTKTRTPSPTSSKSN CCCCCCCCCCCCCCC	39.95	28551015
311	Phosphorylation	KTRTPSPTSSKSNSP CCCCCCCCCCCCCCC	50.39	28551015
312	Phosphorylation	TRTPSPTSSKSNSPQ CCCCCCCCCCCCCCC	38.87	28551015
313	Phosphorylation	RTPSPTSSKSNSPQK CCCCCCCCCCCCCCC	42.45	28551015
317	Phosphorylation	PTSSKSNSPQKHAPV CCCCCCCCCCCCCCE	35.48	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAP2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAP2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAP2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CAP2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.