CAP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAP2_MOUSE
• UniProt AC: Q9CYT6
• Protein Name: Adenylyl cyclase-associated protein 2
• Gene Name: Cap2
• Organism: Mus musculus (Mouse).
• Sequence Length: 476
• Subcellular Localization: Cell membrane; Peripheral membrane protein.
• Protein Description: May have a regulatory bifunctional role..
• Protein Sequence: MTDMAGLMERLERAVIRLEQLSAGLDGPPRGCGEVNGVNGGVAPSVEAFDKLINSMVAEFLKNSRVLAGDVETHAEMVHGAFQAQRAFLLMVSQYQQPQENEVAVLLKPISEKIQEIQTFRERNRGSNMFNHLSAVSESIAALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVRSYLNIWSELQAYIREHHTTGLTWSKTGPVASTASAFSILSSGPGLPPPPPPPPPPGPPPPFENEDKKEEPSPSRSALFAQLNQGEAITKGLRHVTDDKKTYKNPSLRAQGQIRSPTKTHTPSPTSPKSNSPQKHTPVLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCDKSTLQIKGKVNSITVDNCKKFGLVFDHVVGIVEVINSKDIQIQVMGRVPTISINKTEGCHLYLSEDALDCEIVSAKSSEMNVLVPQDDDYREFPIPEQFKTIWDGSKLVTEPAEIMA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Ubiquitination	SMVAEFLKNSRVLAG HHHHHHHHCCCCCCC	59.19	22790023
257	Phosphorylation	EDKKEEPSPSRSALF CCCCCCCCCCHHHHH	38.49	22324799
259	Phosphorylation	KKEEPSPSRSALFAQ CCCCCCCCHHHHHHH	43.11	25521595
261	Phosphorylation	EEPSPSRSALFAQLN CCCCCCHHHHHHHHH	33.39	25521595
275	Ubiquitination	NQGEAITKGLRHVTD HHHHHHHHHHCCCCC	50.24	22790023
288	Ubiquitination	TDDKKTYKNPSLRAQ CCCCCCCCCHHHHHC	68.56	27667366
291	Phosphorylation	KKTYKNPSLRAQGQI CCCCCCHHHHHCCCC	39.62	22324799
300	Phosphorylation	RAQGQIRSPTKTHTP HHCCCCCCCCCCCCC	38.25	25521595
302	Phosphorylation	QGQIRSPTKTHTPSP CCCCCCCCCCCCCCC	50.23	25521595
303	Ubiquitination	GQIRSPTKTHTPSPT CCCCCCCCCCCCCCC	41.51	27667366
304	Phosphorylation	QIRSPTKTHTPSPTS CCCCCCCCCCCCCCC	33.20	25177544
306	Phosphorylation	RSPTKTHTPSPTSPK CCCCCCCCCCCCCCC	30.60	25521595
308	Phosphorylation	PTKTHTPSPTSPKSN CCCCCCCCCCCCCCC	41.80	25521595
310	Phosphorylation	KTHTPSPTSPKSNSP CCCCCCCCCCCCCCC	63.10	25521595
311	Phosphorylation	THTPSPTSPKSNSPQ CCCCCCCCCCCCCCC	33.44	25521595
314	Phosphorylation	PSPTSPKSNSPQKHT CCCCCCCCCCCCCCC	46.02	19060867
316	Phosphorylation	PTSPKSNSPQKHTPV CCCCCCCCCCCCCCE	35.48	21183079
318	Ubiquitination	SPKSNSPQKHTPVLE CCCCCCCCCCCCEEE	50.40	27667366
321	Phosphorylation	SNSPQKHTPVLELEG CCCCCCCCCEEEEEC	23.33	22324799
333	Ubiquitination	LEGKKWRVEYQEDRN EECCEEEEEEECCCC	8.58	27667366
366	Ubiquitination	DKSTLQIKGKVNSIT CCCCEEEEEEEEEEE	39.45	27667366
373	Phosphorylation	KGKVNSITVDNCKKF EEEEEEEEECCHHHH	22.94	21454597
396	Ubiquitination	GIVEVINSKDIQIQV EEEEEECCCCCEEEE	22.15	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CAP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261, AND MASSSPECTROMETRY.
PubMed: 17114649