dbPTM

CANB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CANB2_HUMAN
UniProt AC	Q96LZ3
Protein Name	Calcineurin subunit B type 2
Gene Name	PPP3R2
Organism	Homo sapiens (Human).
Sequence Length	170
Subcellular Localization
Protein Description	Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity..
Protein Sequence	MGNEASYPAEMCSHFDNDEIKRLGRRFKKLDLDKSGSLSVEEFMSLPELRHNPLVRRVIDVFDTDGDGEVDFKEFILGTSQFSVKGDEEQKLRFAFSIYDMDKDGYISNGELFQVLKMMVGNNLTDWQLQQLVDKTIIILDKDGDGKISFEEFSAVVRDLEIHKKLVLIV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNEASYPA ------CCCCCCCCH	40.46	-
79	Phosphorylation	FKEFILGTSQFSVKG HHEEEEEECEEEECC	18.86	26074081
80	Phosphorylation	KEFILGTSQFSVKGD HEEEEEECEEEECCC	27.68	26074081
83	Phosphorylation	ILGTSQFSVKGDEEQ EEEECEEEECCCHHH	18.45	26074081
97	Phosphorylation	QKLRFAFSIYDMDKD HHEEEEEEEEEECCC	19.46	26074081
99	Phosphorylation	LRFAFSIYDMDKDGY EEEEEEEEEECCCCC	12.20	26074081
106	Phosphorylation	YDMDKDGYISNGELF EEECCCCCCCCHHHH	16.00	21082442
106	Ubiquitination	YDMDKDGYISNGELF EEECCCCCCCCHHHH	16.00	-
108	Phosphorylation	MDKDGYISNGELFQV ECCCCCCCCHHHHHH	30.23	-
111	Phosphorylation	DGYISNGELFQVLKM CCCCCCHHHHHHHHH	51.14	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CANB2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CANB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CANB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TFCP2_HUMAN	TFCP2	physical	25416956

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CANB2_HUMAN

Related Literatures of Post-Translational Modification