CANB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CANB1_MOUSE
• UniProt AC: Q63810
• Protein Name: Calcineurin subunit B type 1
• Gene Name: Ppp3r1
• Organism: Mus musculus (Mouse).
• Sequence Length: 170
• Subcellular Localization: Cytoplasm, cytosol . Cell membrane . Cell membrane, sarcolemma . Cell membrane ; Lipid-anchor . Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocyte hypertrophy.
• Protein Description: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity..
• Protein Sequence: MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNEASYPL ------CCCCCCCCH	40.46	-
85	Ubiquitination	GVSQFSVKGDKEQKL CCCEEEECCCHHHHE	61.26	22790023
99	Phosphorylation	LRFAFRIYDMDKDGY EEEEEEEEECCCCCC	10.85	20415495
106	Phosphorylation	YDMDKDGYISNGELF EECCCCCCCCHHHHH	16.00	16141072
108	Phosphorylation	MDKDGYISNGELFQV CCCCCCCCHHHHHHH	30.23	29899451
125	Ubiquitination	MMVGNNLKDTQLQQI HHHCCCCCHHHHHHH	61.93	22790023
135	Ubiquitination	QLQQIVDKTIINADK HHHHHHCCEEECCCC	30.63	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CANB1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CANB1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CANB1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CANB1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-106, AND MASSSPECTROMETRY.
PubMed: 18034455