CAN2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAN2_ARATH
• UniProt AC: F4IH31
• Protein Name: Staphylococcal-like nuclease CAN2
• Gene Name: CAN2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 332
• Subcellular Localization: Cell membrane ; Lipid-anchor .
• Protein Description: Enzyme that catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond. Possesses activity toward the single-stranded DNA, double-stranded DNA and RNA. May be involved in genomic DNA degradation during programmed cell death..
• Protein Sequence: MGNALTFLYGKCCKPTTTDDSLGPHGVSAATVGVSALAHDLFNFEITSQVPEGLGRYVQSSRKAQANWYRKILEAWKQAKPPPQTAEEASRLVTDILKRNQKADVEGLLSFYGLPLSHTLVEVTVEAPVSLPEGILFEFQTLPVDPKAVADGDTITVYVSTSEPVVSSSVPREVNLAAVQRAKAREKRNYPKADELHQKIIDSGYRVLNIENEEVLARKFRIRLRGIDAPESQMPFGKEAQEGLLKIVGRKSLKVLVYGEDQYGRCVGDLYCNGIFVQEAMLKKGLAWHYLAYDKRPVLAKWEKEARQKRIGLWASSNPEKPWDWRKNNRRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNALTFLY ------CCCCHHHHH		-
12	S-palmitoylation	LTFLYGKCCKPTTTD HHHHHCCCCCCCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAN2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAN2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAN2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of CAN2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.