CAN15_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAN15_MOUSE
• UniProt AC: Q9JLG8
• Protein Name: Calpain-15
• Gene Name: Capn15
• Organism: Mus musculus (Mouse).
• Sequence Length: 1095
• Protein Sequence: MATVGEWSCARCTFLNPAGQRQCSICEAPRHKPDLDQILRLSVEEQKWPCARCTFRNFLGKEACEVCGFTPEPVPGAPLLPIINGVLPKPPTILVEPKGSGKEEAGPVRTAGLVATEPARGRPEGEEEREERGEEEEKEQEGEGERAEPGSGWACQRCTLHNTPVASSCSACGGPRKLSLPRIPPEALVVPEVVAPTGFHVVPAPSQPVLPGEGAEADSPSTSQGPTSTDQEPPRVPLFSPFSPTLQNNPVPRSRREVPPQLQPPVPEAVQSSASTSSKGPQQGPGRAAAGASRLAELLSGKELLPGKRLSVLEEEVPESSPARCESCSDVIDLAGDIVRYTPASPSSPDFTTWSCARCTLRNPTTAPRCSVCGGSKLHGFQEHSEPPTHCPDCGANKPGPCVGSCGRAPSAHKAVRLLPDRPGQWACPACTLINTPRAKHCAACHTPQLLVTQCRGATPLRRRESMHVEKRRQTDEGEAKALWENIVAFCRENSVNFVDDSFPPGPASVGFPVGDSVQQRVKQWLRPHEINCSVFRDHGTPWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEGAYQVRLCKDGTWTTVLVDDMLPCDEAGFLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLALQVSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDAAYESLGLRPRHAYSVLDVRDVQGSRLLRLRNPWGRFSWNGSWSDEWPHWPGHLRAELMPHGSSEGVFWMEYSDFIRYFDSVDICKVHSDWQEARVQGCFPSTAGGPVGVTALTVLERASLEFALFQEGSRRSDSVDSHLLDLCILVFRATFGTGGRLSLGRLLAHSKRAVKKFVNCDVMLEPGEYAVVCCAFNHWNPAPPGPPAQASSPSAGVPRGAPEPPGHVLAVYSSRLVMVEPVEAQPTTLADAIILLTESRGERHEGREGMTCYYLTHGWAGLIVVVENRHPKSYLHVQCDCTDSFNVVSTRGSLRTQDSVPPLHRQVLVILSQLEGNAGFSITHRLAHRKAAQAFLSDWTASRGTHSPPLTPDVAGLHGPRPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
179	Phosphorylation	CGGPRKLSLPRIPPE CCCCCCCCCCCCCHH	39.09	22668510
300	Phosphorylation	SRLAELLSGKELLPG HHHHHHHCCCCCCCC	61.52	25338131
302	Ubiquitination	LAELLSGKELLPGKR HHHHHCCCCCCCCCC	41.64	22790023
311	Phosphorylation	LLPGKRLSVLEEEVP CCCCCCHHHCEECCC	28.79	26239621
320	Phosphorylation	LEEEVPESSPARCES CEECCCCCCCCCCCC	35.24	25338131
321	Phosphorylation	EEEVPESSPARCESC EECCCCCCCCCCCCH	22.40	25338131
345	Phosphorylation	IVRYTPASPSSPDFT EEEECCCCCCCCCCC	26.90	26643407
347	Phosphorylation	RYTPASPSSPDFTTW EECCCCCCCCCCCCC	52.59	26643407
348	Phosphorylation	YTPASPSSPDFTTWS ECCCCCCCCCCCCCE	31.69	26643407
696	Ubiquitination	WAKMLSSKEAGFLMG HHHHCCCCCCCEECC	48.48	22790023
931 (in isoform 2)	Phosphorylation	-	52.04	28285833
936 (in isoform 2)	Phosphorylation	-	38.83	29472430
937 (in isoform 2)	Phosphorylation	-	43.81	29472430
941 (in isoform 2)	Phosphorylation	-	1.90	29514104
944 (in isoform 2)	Phosphorylation	-	8.70	26643407
1077	Phosphorylation	DWTASRGTHSPPLTP HHHHCCCCCCCCCCC	20.33	25293948
1079	Phosphorylation	TASRGTHSPPLTPDV HHCCCCCCCCCCCCC	28.22	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAN15_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAN15_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAN15_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CAN15_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.