dbPTM

CALY_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CALY_RAT
UniProt AC	P58821
Protein Name	Neuron-specific vesicular protein calcyon
Gene Name	Caly
Organism	Rattus norvegicus (Rat).
Sequence Length	226
Subcellular Localization	Cytoplasmic vesicle membrane Single-pass membrane protein . Cell membrane Single-pass membrane protein.
Protein Description	Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis..
Protein Sequence	MVKLGCSFSGKPGKETGDQDGAAMDSVPLISPLDVSQLQPSFPDQVVIKTQTEYQLTSADQPKKFADLEGQRLACSHPEEGRRLPTARMIAFAMALLGCVLIMYKAIWYDQFTCPDGFLLRHKICTPLTLEMYYTEMDPERHRSILAAIGAYPLSRKHGTEMPAIWGNSYRAGKEEHKGTTPAAMTVSTAAAAAAAEGNEPSGKPLDMREKEDPQKAEDVPSQSPK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	VIKTQTEYQLTSADQ EEEECCEEEECCCCC	16.53	-
63	Ubiquitination	LTSADQPKKFADLEG ECCCCCCCCHHCCCC	55.69	-
64	Ubiquitination	TSADQPKKFADLEGQ CCCCCCCCHHCCCCC	53.09	-
86	Phosphorylation	EEGRRLPTARMIAFA HHCCCCCHHHHHHHH	31.33	26022182
169	Phosphorylation	MPAIWGNSYRAGKEE CCCCCCCCCCCCCHH	16.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
169	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
169	S	Phosphorylation	Kinase	PKCA	P05696	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CALY_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CALY_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CALY_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CALY_RAT

Related Literatures of Post-Translational Modification