| UniProt ID | CALCB_HUMAN | |
|---|---|---|
| UniProt AC | P10092 | |
| Protein Name | Calcitonin gene-related peptide 2 | |
| Gene Name | CALCB | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 127 | |
| Subcellular Localization | Secreted. | |
| Protein Description | CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.. | |
| Protein Sequence | MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKEDARLLLAALVQDYVQMKASELKQEQETQGSSSAAQKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGRRRRDLQA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 34 | O-linked_Glycosylation | PFRSALESSPDPATL CHHHHHHHCCCHHCC | 48.28 | 55830353 | |
| 35 | O-linked_Glycosylation | FRSALESSPDPATLS HHHHHHHCCCHHCCC | 24.77 | 55830357 | |
| 40 | O-linked_Glycosylation | ESSPDPATLSKEDAR HHCCCHHCCCHHHHH | 36.63 | 55830361 | |
| 106 | O-linked_Glycosylation | RSGGMVKSNFVPTNV HCCCCCCCCCCCCCC | 24.88 | 55828463 | |
| 111 | O-linked_Glycosylation | VKSNFVPTNVGSKAF CCCCCCCCCCCCCHH | 36.92 | 55828467 | |
| 115 | O-linked_Glycosylation | FVPTNVGSKAFGRRR CCCCCCCCCHHCCHH | 19.27 | 55828471 | |
| 118 | Phenylalanine amide | TNVGSKAFGRRRRDL CCCCCCHHCCHHHHC | 10.07 | - | |
| 118 | Amidation | TNVGSKAFGRRRRDL CCCCCCHHCCHHHHC | 10.07 | 2322288 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CALCB_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CALCB_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CALCB_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CALCB_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Amidation | |
| Reference | PubMed |
| "Isolation, purification and characterization of beta-hCGRP from humanspinal cord."; Wimalawansa S.J., Morris H.R., Etienne A., Blench I., Panico M.,McIntyre I.; Biochem. Biophys. Res. Commun. 167:993-1000(1990). Cited for: PROTEIN SEQUENCE OF 82-86 AND 104-118, AMIDATION AT PHE-118, ANDDISULFIDE BOND. | |
