CAH3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAH3_HUMAN
• UniProt AC: P07451
• Protein Name: Carbonic anhydrase 3
• Gene Name: CA3
• Organism: Homo sapiens (Human).
• Sequence Length: 260
• Subcellular Localization: Cytoplasm.
• Protein Description: Reversible hydration of carbon dioxide..
• Protein Sequence: MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTILNNGKTCRVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDPSCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPLVSNWRPPQPINNRVVRASFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAKEWGYAS ------CCCCCCCCC	20.62	-
9	Phosphorylation	AKEWGYASHNGPDHW CCCCCCCCCCCCCCH	14.70	26437602
29	Phosphorylation	NAKGENQSPVELHTK CCCCCCCCCCEEECC	42.36	-
43	Phosphorylation	KDIRHDPSLQPWSVS CCCCCCCCCCCCEEE	45.77	26437602
48	Phosphorylation	DPSLQPWSVSYDGGS CCCCCCCEEEECCCC	14.10	19764811
50	Phosphorylation	SLQPWSVSYDGGSAK CCCCCEEEECCCCCE	16.40	19764811
51	Phosphorylation	LQPWSVSYDGGSAKT CCCCEEEECCCCCEE	19.22	22673903
55	Phosphorylation	SVSYDGGSAKTILNN EEEECCCCCEEHHHC	31.93	22673903
58	Phosphorylation	YDGGSAKTILNNGKT ECCCCCEEHHHCCCE	30.34	26437602
66	S-nitrosylation	ILNNGKTCRVVFDDT HHHCCCEEEEEECCC	3.37	24105792
73	Phosphorylation	CRVVFDDTYDRSMLR EEEEECCCCCHHHHC	29.21	22673903
74	Phosphorylation	RVVFDDTYDRSMLRG EEEECCCCCHHHHCC	19.16	-
77	Phosphorylation	FDDTYDRSMLRGGPL ECCCCCHHHHCCCCC	21.19	22673903
88	Phosphorylation	GGPLPGPYRLRQFHL CCCCCCCCEEEEEEE	28.35	26437602
99	Phosphorylation	QFHLHWGSSDDHGSE EEEEECCCCCCCCCC	25.96	26437602
100	Phosphorylation	FHLHWGSSDDHGSEH EEEECCCCCCCCCCC	43.02	26437602
105	Phosphorylation	GSSDDHGSEHTVDGV CCCCCCCCCCEECHH	23.84	22673903
108	Phosphorylation	DDHGSEHTVDGVKYA CCCCCCCEECHHHEE	19.08	22673903
114	Phosphorylation	HTVDGVKYAAELHLV CEECHHHEEEEEEEC	14.50	26437602
126	Acetylation	HLVHWNPKYNTFKEA EECCCCCCCHHHHHH	48.17	20167786
127	Phosphorylation	LVHWNPKYNTFKEAL ECCCCCCCHHHHHHH	22.23	-
129	Phosphorylation	HWNPKYNTFKEALKQ CCCCCCHHHHHHHHC	32.75	19764811
176	Phosphorylation	KGKEAPFTKFDPSCL CCCCCCCCCCCHHHH	29.73	-
182	S-glutathionyl cysteine	FTKFDPSCLFPACRD CCCCCHHHHCHHHCC	5.74	-
182	Glutathionylation	FTKFDPSCLFPACRD CCCCCHHHHCHHHCC	5.74	22833525
187	Glutathionylation	PSCLFPACRDYWTYQ HHHHCHHHCCCEEEC	3.28	8633035
187	S-glutathionyl cysteine	PSCLFPACRDYWTYQ HHHHCHHHCCCEEEC	3.28	-
216	Phosphorylation	LLLKEPMTVSSDQMA HHHCCCCCCCHHHHH	28.14	26437602
218	Phosphorylation	LKEPMTVSSDQMAKL HCCCCCCCHHHHHHH	21.02	26437602
219	Phosphorylation	KEPMTVSSDQMAKLR CCCCCCCHHHHHHHH	27.76	26437602
227	Phosphorylation	DQMAKLRSLLSSAEN HHHHHHHHHHHCCCC	44.06	26437602
242	Phosphorylation	EPPVPLVSNWRPPQP CCCCCCCCCCCCCCC	38.06	19764811
258	Phosphorylation	NNRVVRASFK----- CCCEEEHHCC-----	24.01	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAH3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAH3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAH3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CAH3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00819: Acetazolamide
• DB00909: Zonisamide