CADM2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CADM2_RAT
• UniProt AC: Q1WIM2
• Protein Name: Cell adhesion molecule 2
• Gene Name: Cadm2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 435
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell projection, axon. Found in the axoplasm of myelinated axons..
• Protein Description: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes (By similarity)..
• Protein Sequence: MIWKRSAVLRFYSVCGLLLLGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQALTLTCESKGKPLPEPVLWTKDGAELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDVPNTLLPTTIIPSLTTAPVTTTVAITTSPSTSASSSSRRDPNSLAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQVNAEEKKEYFI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	N-linked_Glycosylation	GQFPLTQNVTVVEGG CCCCCCCCEEEEECC	26.62	-
51	N-linked_Glycosylation	CRVDQNDNTSLQWSN EEECCCCCCCEEECC	38.83	24090084
291	N-linked_Glycosylation	LFLNKTDNGTYRCEA EEEECCCCCEEEEEE	50.35	-
396	Ubiquitination	GRYLARHKGTYLTNE HHHHHHCCCCCCCCC	47.60	-
405	Ubiquitination	TYLTNEAKGAEDAPD CCCCCCCCCCCCCCC	53.10	-
415	Phosphorylation	EDAPDADTAIINAEG CCCCCCCEEEEECCC	22.83	28551015
423	Phosphorylation	AIINAEGSQVNAEEK EEEECCCCCCCHHHH	23.59	27097102
430	Ubiquitination	SQVNAEEKKEYFI-- CCCCHHHHHHHCC--	42.27	-
431	Ubiquitination	QVNAEEKKEYFI--- CCCHHHHHHHCC---	62.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CADM2_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
51	N	Glycosylation	Glycosylation at Asn-51 reduces adhesive binding.	24090084

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CADM2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CADM2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.