CADH2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CADH2_RAT
• UniProt AC: Q9Z1Y3
• Protein Name: Cadherin-2
• Gene Name: Cdh2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 906
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Cell junction . Cell surface . Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes.
• Protein Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity)..
• Protein Sequence: MCRIAGGPRTLLPLLAALLQASLEASGELALCKTGFPEDVYSAVLPKTVHEGQPLLNVKFSNCNRKRKVQYESSEPADFKVDEDGTVYAVRSFPLSAEQAKFLIYAQDKETQEKWQVAVNLSLEPSLTEEPMKEPHEIEEIVFPRQLAKHSGALQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGSVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRILSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDVIVANLTVTDKDQPHTPAWNAAYRISGGDPTGRFAILTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTLTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPEPNSINITALDYDIDPNAGPFAFDLPLSPATIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIVITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGTIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRLDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYGGGDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
92	Phosphorylation	GTVYAVRSFPLSAEQ CCEEEEEECCCCHHH	25.31	28432305
96	Phosphorylation	AVRSFPLSAEQAKFL EEEECCCCHHHHEEE	29.96	28432305
190	N-linked_Glycosylation	IRSDRDKNLSLRYSV ECCCCCCCEEEEEEE	38.87	-
273	N-linked_Glycosylation	EFLHQVWNGSVPEGS HHHHHHHCCCCCCCC	33.72	-
325	N-linked_Glycosylation	PNMFTINNETGDIIT CCEEEECCCCCCEEE	44.34	-
402	N-linked_Glycosylation	RVDVIVANLTVTDKD CEEEEEEECEECCCC	25.92	-
439	Phosphorylation	AILTDPNSNDGLVTV EEEECCCCCCCCEEE	41.51	27097102
572	N-linked_Glycosylation	NVKNNIYNATFLASD CCCCCEEEEEEEEEC	28.80	-
622	N-linked_Glycosylation	TPEPNSINITALDYD CCCCCCEEEEEEEEE	25.94	-
651	N-linked_Glycosylation	SPATIKRNWTITRLN CHHHHCCCEEEEEEC	34.93	-
692	N-linked_Glycosylation	SGNPPKSNISILRVK CCCCCCCCEEEEEEE	37.85	-
756	Ubiquitination	RDKERQAKQLLIDPE CCHHHHHHHHCCCCC	32.89	-
785	Phosphorylation	GGEEDQDYDLSQLQQ CCCCCCCCCHHHCCC	17.10	22276854
820	Phosphorylation	PIHAEPQYPVRSAAP CCCCCCCCCCCCCCC	17.89	-
824	Phosphorylation	EPQYPVRSAAPHPGD CCCCCCCCCCCCCCC	29.08	30181290
869	Phosphorylation	GSGSTAGSLSSLNSS CCCCCCCCHHHCCCC	23.71	-
871	Phosphorylation	GSTAGSLSSLNSSSS CCCCCCHHHCCCCCC	34.18	-
872	Phosphorylation	STAGSLSSLNSSSSG CCCCCHHHCCCCCCC	36.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
869	S	Phosphorylation	Kinase	PRKD1	Q15139	PSP
869	S	Phosphorylation	Kinase	PRKD1	Q9WTQ1	PSP
871	S	Phosphorylation	Kinase	PRKD1	Q15139	PSP
871	S	Phosphorylation	Kinase	PRKD1	Q9WTQ1	PSP
872	S	Phosphorylation	Kinase	PRKD1	Q15139	PSP
872	S	Phosphorylation	Kinase	PRKD1	Q9WTQ1	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CADH2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CADH2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CADH2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.