CAD89_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAD89_DROME
• UniProt AC: Q9VEU1
• Protein Name: Cadherin-89D
• Gene Name: Cad89D
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2240
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity)..
• Protein Sequence: MDSEAYPMKSSVKISQKKKASQDMAVICVWVMPLAVFGLIAIGQAAKTGQVQASSGSCAFHTLDGVAAESEGVRFIRLREDAQVGKEILRLQAYPRSTAALKGADASGDHKYFNLTEHNATTLVVSLARSLERLVDRDVPRNLLKFRILCAGKQEKLEEGSYLSITVYIEDVNDNAPEFLNVPYVVDVDENTSIESIIFEGVQAFDRDKPNTPNSEVHFSMSTVPEQLSADGSPYFALKSPHRPLLILKRELDFDNGIRQFKLPIFAWDRGTPANQANTTITINVRDVDDLPPKFTEGVYRTRINEFYPMTGVPIRIPLYFAPPIMAFDQDSLNASLVYDIISGNERQLFRVNPHNGVMYLQKEIDLEEESLPGNTFVLQLEARQKDNPLKKALARIEVEVLDLNDNVPEFEADYYNISIVENLPTGFSVLQVNAVDRDQGENSEFLYNLVETKDAAGAFRIDSRTGWITVRDDRLLDREQRRSIQLNVEALERNPSYLDDKHLKKPGPSKVQVEITLLDTNDNTPKFEHGNLYEFKVPINAPTGYVIGQVVAHDPDEGPNGHLLYELQRPKGSGYIPFRLDNKNGTIYVGGPLRRGRIAVFVEATDQPTNPSERRFSLAVITIEVYATIDDQAIDFVGAPYEFWVGANTPLGTSVGQVRTTLIYEGGDEIMYDLLHTYSEGVPFAIEERSGIITVIRELSEFKRKVYQFEAVANYLFANSSQSLVMSRSSSPLTTIASPAELSDEGVLITNLTIHIVNKPEQKVPLRPVIEEINMNVIHFHVEENVVGGIIGQLLYKNGINLVNNELGTYREMPSEPTSRNITMGSRFRSRNRSRSSKSKRRLPRRLVGDANIKLRYIIANQQEVVNKISITEDGTLLTLTGLDREQQPSYELTVIVEYSTGLVSGAGIYQVNIKVDDVNDNAPKFNALTYVGLINENCVVGTELSMNHAILIQDADEGPNAEFRVQLQGDYSDEFSIEYVNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTFMQTNFKLSSGPYFRISYTGKRGLDREKQQLYNLKIIAADTGGLSGYAHLTVLVADVNDNAPMFERISVFKDSRLEIREYTTDMEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAGLGVVARAKSRRRMVRALTTKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYELQGEQVERTPGMPMLRVHGVKYFAIDKLSGELSVNYPLSANIEIMLNLTVTDIDGLKDSTCLRFTVMDVNNHAPTFKKSWYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTLSDSHLPFTIKPASGVLKIGGQLDRELKDKYSFQVIATDNAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSVADRTLMLPVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSIRHQEMQAPLFQIDSRDGTISTISRINGYNDYEHLNVSVIASDVGSPALSATAIVIVNLQGQAVTDPPKSTPKPEPPANVTVFQHAYYEVKLTENNEAPIEVMRLNLSAGLNPENYRWSLWLEEGLDETDAHPPFEYDAKNMLLYALKPFDREHISRYQLRIRADRLSREARNYARVSYPVVDERIEGLSLNECRILVHIADENDNAPKFRGNGQPIVAVLPQSASFGYPVTRVEANDLDEGLNAEIRYRLLNEPARLFGIDELSGNIRLLGELSRTEHIYGFDVKATDRMGADDGRSGIVNVFVYIINEAKQVRLVVAGMPVEVERRIEGLMEALSDAIGKDVRVRLLEPYSGGLEPATNAYIYAVDPHTNSIMEMEQLQDALAGLQLDALQLQQQKLDGGKPMPRILELAEFGQLARPAHASASSFMGGLEFVTVVLLALISLGALIAACCYVCMRQKRRLWSQRDFSASDAGLTYTIAGIGSPRGQKQRRQRQQRHTQRCSKGSTGSQRPTSAFMPESVCSSAQTQSTATATEKLEQQLHHHHQQQAMATQQQHHQYLNEQQRQQKREYIDVPLPKSIAKAAAVTSGGDGAVGVGSTPFVLKYNACQPVNNLNNYETSLFSLHSTGQDSGVEFLSSRELYETSPDSFQHGGSKRGNNTEVLCPRHAKAHLELRQPNTDSSDTYEDSLKTDEPLVAHNCRSANCEHRQHQQHPSHHPHYQNTRFEKRSCVRHSFSGVKDDLMQQSPQISLRPRGHALRNSMNDLEQRLHNLEQSFRRPLEFSKSNSLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
114	N-linked_Glycosylation	SGDHKYFNLTEHNAT CCCCCCEECCCCCHH	42.85	-
119	N-linked_Glycosylation	YFNLTEHNATTLVVS CEECCCCCHHHHHHH	32.52	-
191	N-linked_Glycosylation	YVVDVDENTSIESII EEEECCCCCCEEEEE	34.36	-
278	N-linked_Glycosylation	GTPANQANTTITINV CCCCCCCCCEEEEEE	28.17	-
334	N-linked_Glycosylation	AFDQDSLNASLVYDI ECCCCCCCEEEEEEH	31.28	-
417	N-linked_Glycosylation	EFEADYYNISIVENL CCCCEEECEEEEECC	18.46	-
585	N-linked_Glycosylation	PFRLDNKNGTIYVGG CEEEECCCCEEEECC	60.12	-
720	N-linked_Glycosylation	VANYLFANSSQSLVM HHHHHHCCCCCEEEE	34.55	-
752	N-linked_Glycosylation	DEGVLITNLTIHIVN CCCEEEEEEEEEEEC	28.35	-
822	N-linked_Glycosylation	PSEPTSRNITMGSRF CCCCCCCCCCCCHHH	33.57	-
833	N-linked_Glycosylation	GSRFRSRNRSRSSKS CHHHHHCCCCCCCCC	47.75	-
983	N-linked_Glycosylation	EFSIEYVNGTSSENS CEEEEEECCCCCCCC	47.31	-
989	N-linked_Glycosylation	VNGTSSENSTHHKMP ECCCCCCCCCCCCCC	54.90	-
1006	N-linked_Glycosylation	TGAFNIFNLTDQWND CCCEEEECCCCCCCC	37.93	-
1255	N-linked_Glycosylation	ANIEIMLNLTVTDID CCEEEEEECEEECCC	19.11	-
1318	N-linked_Glycosylation	MDFGENANITYTLSD CCCCCCCEEEEEECC	38.42	-
1486	N-linked_Glycosylation	YNDYEHLNVSVIASD CCCCCCEEEEEEEEC	26.40	-
1529	N-linked_Glycosylation	PKPEPPANVTVFQHA CCCCCCCCEEEEEEE	35.45	-
1556	N-linked_Glycosylation	PIEVMRLNLSAGLNP CEEEEEEEECCCCCH	22.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAD89_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAD89_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAD89_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of CAD89_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.