CAD26_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAD26_HUMAN
• UniProt AC: Q8IXH8
• Protein Name: Cadherin-like protein 26
• Gene Name: CDH26
• Organism: Homo sapiens (Human).
• Sequence Length: 852
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types..
• Protein Sequence: MAMRSGRHPSLLLLLVLLLWLLQVSIIDSVQQETDDLTKQTKEKIYQPLRRSKRRWVITTLELEEEDPGPFPKLIGELFNNMSYNMSLMYLISGPGVDEYPEIGLFSLEDHENGRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDTSLIFNIRISDVNDHAPQFPEKEFNITVQENQSAGQPIFQMLAVDLDEENTPNSQVLYFLISQTPLLKESGFRVDRLSGEIRLSGCLDYETAPQFTLLIRARDCGEPSLSSTTTVHVDVQEGNNHRPAFTQENYKVQIPEGRASQGVLRLLVQDRDSPFTSAWRAKFNILHGNEEGHFDISTDPETNEGILNVIKPLDYETRPAQSLIIVVENEERLVFCERGKLQPPRKAAASATVSVQVTDANDPPAFHPQSFIVNKEEGARPGTLLGTFNAMDPDSQIRYELVHDPANWVSVDKNSGVVITVEPIDRESPHVNNSFYVIIIHAVDDGFPPQTATGTLMLFLSDINDNVPTLRPRSRYMEVCESAVHEPLHIEAEDPDLEPFSDPFTFELDNTWGNAEDTWKLGRNWGQSVELLTLRSLPRGNYLVPLFIGDKQGLSQKQTVHVRICPCASGLTCVELADAEVGLHVGALFPVCAAFVALAVALLFLLRCYFVLEPKRHGCSVSNDEGHQTLVMYNAESKGTSAQTWSDVEGQRPALLICTAAAGPTQGVKAYPDATMHRQLLAPVEGRMAETLNQSKERNRFSLSRGCIIPQGRATAGRGLPQDIYKEMMPRRLTQTGKRKHGALARTPSFKKVVYDHKEDEENKAGRKQRSHLFKVMQLRNEQGGVRVQSAHSPSPLNKKACFPGDYRGESAGGHNCRAVSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	N-linked_Glycosylation	LIGELFNNMSYNMSL HHHHHHHCCCCCEEE	17.28	UniProtKB CARBOHYD
85	N-linked_Glycosylation	LFNNMSYNMSLMYLI HHHCCCCCEEEEHHH	13.27	UniProtKB CARBOHYD
171	N-linked_Glycosylation	QFPEKEFNITVQENQ CCCHHHEEEEECCCC	30.07	UniProtKB CARBOHYD
177	N-linked_Glycosylation	FNITVQENQSAGQPI EEEEECCCCCCCCCC	24.82	UniProtKB CARBOHYD
197	Phosphorylation	VDLDEENTPNSQVLY ECCCCCCCCCHHHHH	27.42	-
200	Phosphorylation	DEENTPNSQVLYFLI CCCCCCCHHHHHHEE	23.91	-
210	Phosphorylation	LYFLISQTPLLKESG HHHEEECCCCHHHCC	14.76	24719451
380	Phosphorylation	PPRKAAASATVSVQV CCCHHCCCCEEEEEE	21.53	26074081
382	Phosphorylation	RKAAASATVSVQVTD CHHCCCCEEEEEEEC	15.72	26074081
384	Phosphorylation	AAASATVSVQVTDAN HCCCCEEEEEEECCC	11.50	26074081
388	Phosphorylation	ATVSVQVTDANDPPA CEEEEEEECCCCCCC	16.59	26074081
400	Phosphorylation	PPAFHPQSFIVNKEE CCCCCCCEEEEECCC	22.76	26074081
405	Acetylation	PQSFIVNKEEGARPG CCEEEEECCCCCCCC	46.37	12654923
413	Phosphorylation	EEGARPGTLLGTFNA CCCCCCCCEEEEEEC	22.84	-
417	Phosphorylation	RPGTLLGTFNAMDPD CCCCEEEEEECCCCC	17.43	-
425	Phosphorylation	FNAMDPDSQIRYELV EECCCCCCCEEEEEE	32.66	-
462	N-linked_Glycosylation	DRESPHVNNSFYVII CCCCCCCCCEEEEEE	35.08	UniProtKB CARBOHYD
566	Phosphorylation	VELLTLRSLPRGNYL EEEEEECCCCCCCEE	45.93	20049867
572	Phosphorylation	RSLPRGNYLVPLFIG CCCCCCCEEEEEEEE	16.35	20049867
777	Phosphorylation	KHGALARTPSFKKVV CCCCCCCCCCCEEEE	20.06	26074081
779	Phosphorylation	GALARTPSFKKVVYD CCCCCCCCCEEEEEC	49.43	26074081
785	Phosphorylation	PSFKKVVYDHKEDEE CCCEEEEECCCCHHC	18.47	26074081
820	Phosphorylation	QGGVRVQSAHSPSPL CCCEEEEECCCCCCC	25.70	26074081
823	Phosphorylation	VRVQSAHSPSPLNKK EEEEECCCCCCCCCC	27.13	26074081
825	Phosphorylation	VQSAHSPSPLNKKAC EEECCCCCCCCCCCC	45.06	26074081
837	Phosphorylation	KACFPGDYRGESAGG CCCCCCCCCCCCCCC	26.82	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAD26_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAD26_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAD26_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CAD26_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.