CAD22_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAD22_HUMAN
• UniProt AC: Q9UJ99
• Protein Name: Cadherin-22
• Gene Name: CDH22
• Organism: Homo sapiens (Human).
• Sequence Length: 828
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity)..
• Protein Sequence: MRPRPEGRGLRAGVALSPALLLLLLLPPPPTLLGRLWAAGTPSPSAPGARQDGALGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGSPPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYAGHRGDDEAQAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	LRAGVALSPALLLLL CCHHCCCCHHHHHHH	9.82	22210691
41	Phosphorylation	GRLWAAGTPSPSAPG HHHHHCCCCCCCCCC	18.83	22210691
134	Phosphorylation	REQKTFYTLRAQARD HHHCHHHHHHHHHHH	12.94	24719451
152	Phosphorylation	NRLLEPESEFIIKVQ HCCCCCCCEEEEEEE	48.82	22817900
162	N-linked_Glycosylation	IIKVQDINDSEPRFL EEEEECCCCCCCCCC	55.86	UniProtKB CARBOHYD
181	Phosphorylation	IGSVAELSPTGTSVM CCCEEECCCCCCCHH	16.36	22817900
193	Phosphorylation	SVMQVMASDADDPTY CHHHHEECCCCCCCC	18.42	22817900
314	Phosphorylation	GENTDMTYHLKDESS CCCCEEEEECCCCCC	9.87	-
330	Phosphorylation	GGDVFKVTTDSDTQE CCCEEEEEECCCCCE	26.02	-
331	Phosphorylation	GDVFKVTTDSDTQEA CCEEEEEECCCCCEE	36.17	-
333	Phosphorylation	VFKVTTDSDTQEAII EEEEEECCCCCEEEE	40.23	-
335	Phosphorylation	KVTTDSDTQEAIIVV EEEECCCCCEEEEEE	32.06	-
430	Phosphorylation	AANRPVRYAIDRESD HHCCCCEEEECCCCC	14.24	-
461	Phosphorylation	GKGLDRETAGWHNIT CCCCCCCCCCCCCEE	31.22	22210691
466	N-linked_Glycosylation	RETAGWHNITVLAME CCCCCCCCEEEEEEE	25.72	UniProtKB CARBOHYD
468	Phosphorylation	TAGWHNITVLAMEAD CCCCCCEEEEEEECC	18.13	22210691
481	Phosphorylation	ADNHAQLSRASLRIR CCCHHHHHCCEEEEE	17.45	22210691
484	Phosphorylation	HAQLSRASLRIRILD HHHHHCCEEEEEEEE	19.64	22210691
612	N-linked_Glycosylation	SGTIQSCNTTAFVMA CCCCCCCCCHHHHHH	45.79	UniProtKB CARBOHYD
653	Phosphorylation	TLRRHHKSHLSSDED HHHHHHHHCCCCCCC	25.88	-
656	Phosphorylation	RHHKSHLSSDEDEDM HHHHHCCCCCCCHHH	30.25	-
657	Phosphorylation	HHKSHLSSDEDEDMR HHHHCCCCCCCHHHH	51.91	-
670	Phosphorylation	MRDNVIKYNDEGGGE HHHCEEEECCCCCCC	19.40	-
720	Phosphorylation	GSGGGAGSPPQAHLP CCCCCCCCCCCCCCC	32.64	25307156
728	Phosphorylation	PPQAHLPSERHSLPQ CCCCCCCCCCCCCCC	54.33	24719451
739	Phosphorylation	SLPQGPPSPEPDFSV CCCCCCCCCCCCCHH	45.06	24076635

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAD22_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAD22_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAD22_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CAD22_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.