CAD13_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAD13_MOUSE
• UniProt AC: Q9WTR5
• Protein Name: Cadherin-13
• Gene Name: Cdh13
• Organism: Mus musculus (Mouse).
• Sequence Length: 714
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor.
• Protein Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth..
• Protein Sequence: MQPRTPLTLCVLLSQVLLVTSADDLECTPGFQRKVLHIHQPAEFIEDQPVLNLTFNDCKGNEKLHYEVSSPHFKVNSDGTLVALRNITAVGRTLFVHARTPHAEDMAELVIVGGKDIQGSLQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPEGSKFRLTGKGVDQDPKGTFRINENTGSVSVTRTLDRETIATYQLYVETTDASGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIVIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTKQENISVGSVLLTVNATDPDSLQHQTIRYSIYKDPAGWLSINPINGTVDTTAVLDRESPFVHNSVYTALFLAIDSGNPPATGTGTLLITLEDINDNAPVIYPTVAEVCDDARNLSVVILGASDKDLHPNTDPFKFEIHKQTVPDKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSCKNSKVDCNGAGALHLSLSLLLLFSLLSLLSGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	DQPVLNLTFNDCKGN CCCEEEEEEECCCCC	21.22	-
130	Phosphorylation	DIFKFARTSPVPRQK HHHHHHHCCCCCCCC	33.67	23737553
131	Phosphorylation	IFKFARTSPVPRQKR HHHHHHCCCCCCCCC	20.53	23737553
139	Phosphorylation	PVPRQKRSIVVSPIL CCCCCCCEEEEECCC	27.11	27742792
176	Phosphorylation	EGSKFRLTGKGVDQD CCCCEEEEECCCCCC	32.37	21454597
187	Phosphorylation	VDQDPKGTFRINENT CCCCCCCCEEECCCC	18.83	21454597
327	Phosphorylation	ETLENPKYELIIEAQ HHHCCCCEEEEEEEH	19.75	22817900
382	N-linked_Glycosylation	GAVGVIVNLTVEDKD CCEEEEEEEEECCCC	20.90	-
489	N-linked_Glycosylation	MMVTKQENISVGSVL EEEEECCCEECCEEE	29.37	-
500	N-linked_Glycosylation	GSVLLTVNATDPDSL CEEEEEEECCCHHHH	31.71	-
530	N-linked_Glycosylation	WLSINPINGTVDTTA CEEEECCCCEEECCE	41.14	-
598	N-linked_Glycosylation	EVCDDARNLSVVILG HHCCCCCCEEEEEEC	38.09	-
638	N-linked_Glycosylation	VWKISKINNTHALVS EEEEEEECCHHHHHH	51.59	-
671	N-linked_Glycosylation	SGKPPMTNITDLRVQ CCCCCCCCCCEEEEE	28.98	-
693	GPI-anchor	KVDCNGAGALHLSLS CCCCCCHHHHHHHHH	30.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAD13_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAD13_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAD13_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CAD13_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.