CACP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CACP_MOUSE
• UniProt AC: P47934
• Protein Name: Carnitine O-acetyltransferase
• Gene Name: Crat
• Organism: Mus musculus (Mouse).
• Sequence Length: 626
• Subcellular Localization: Endoplasmic reticulum . Peroxisome . Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
• Protein Description: Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria..
• Protein Sequence: MLAFAARTVVKPLGLLKPSSLMKVSGRFKAHQDALPRLPVPPLQQSLDYYLKALQPIVSEEEWAHTKQLVDEFQTSGGVGERLQKGLERRAKKMENWLSEWWLKTAYLQFRQPVVIYSSPGVILPKQDFVDLQGQLRFAAKLIEGVLDFKSMIDNETLPVEFLGGQPLCMNQYYQILSSCRVPGPKQDSVVNFLKSKRPPTHITVVHNYQFFELDVYHSDGTPLTSDQIFVQLEKIWNSSLQSNKEPVGILTSNHRNTWAKAYNNLIKDKVNRESVNSIQKSIFTVCLDKQVPRVSDDVYRNHVAGQMLHGGGSKFNSGNRWFDKTLQFIVAEDGSCGMVYEHAAAEGPPIVALVDHVMEYTKKPELVRSPMVPLPMPKKLRFNITPEIKNDIEKAKQNLSIMIQDLDIMMLTFHHFGKDFPKSEKLSPDAFIQVALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASIDSLAFVKGMGDSTVPEQQKVELLRKAVQAHRAYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFNLSTSQVPAKTDCVMFFGPVVPDGYGICYNPMEAHINFSVSAYNSCAETNAARMAHYLEKALLDMRTLLQNHPRAKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
93	Succinylation	GLERRAKKMENWLSE HHHHHHHHHHHHHHH	50.92	-
93	Succinylation	GLERRAKKMENWLSE HHHHHHHHHHHHHHH	50.92	23806337
93	Acetylation	GLERRAKKMENWLSE HHHHHHHHHHHHHHH	50.92	23806337
186	Acetylation	SCRVPGPKQDSVVNF CCCCCCCCCHHHHHH	73.06	23806337
186	Succinylation	SCRVPGPKQDSVVNF CCCCCCCCCHHHHHH	73.06	23806337
195	Acetylation	DSVVNFLKSKRPPTH HHHHHHHHCCCCCCE	50.20	23201123
245	Acetylation	NSSLQSNKEPVGILT HHHCCCCCCCEEEEC	69.51	24062335
245	Succinylation	NSSLQSNKEPVGILT HHHCCCCCCCEEEEC	69.51	26388266
261	Succinylation	NHRNTWAKAYNNLIK CCHHHHHHHHHHHHH	42.86	23806337
261	Acetylation	NHRNTWAKAYNNLIK CCHHHHHHHHHHHHH	42.86	23806337
261	Succinylation	NHRNTWAKAYNNLIK CCHHHHHHHHHHHHH	42.86	-
268	Acetylation	KAYNNLIKDKVNRES HHHHHHHHHHCCHHH	55.45	24062335
268	Succinylation	KAYNNLIKDKVNRES HHHHHHHHHHCCHHH	55.45	26388266
270	Acetylation	YNNLIKDKVNRESVN HHHHHHHHCCHHHHH	36.09	24062335
281	Acetylation	ESVNSIQKSIFTVCL HHHHHHHHHHHHHHH	43.80	24062335
287	S-nitrosylation	QKSIFTVCLDKQVPR HHHHHHHHHCCCCCC	3.55	21278135
287	S-nitrosocysteine	QKSIFTVCLDKQVPR HHHHHHHHHCCCCCC	3.55	-
290	Acetylation	IFTVCLDKQVPRVSD HHHHHHCCCCCCCCC	40.00	24062335
296	Phosphorylation	DKQVPRVSDDVYRNH CCCCCCCCCHHHHCC	29.40	23684622
314	Phosphorylation	QMLHGGGSKFNSGNR CCCCCCCCCCCCCCC	37.03	30165576
315	Acetylation	MLHGGGSKFNSGNRW CCCCCCCCCCCCCCC	52.41	23806337
315	Succinylation	MLHGGGSKFNSGNRW CCCCCCCCCCCCCCC	52.41	23806337
370	Phosphorylation	KKPELVRSPMVPLPM CCCHHHCCCCCCCCC	15.18	27180971
379	Succinylation	MVPLPMPKKLRFNIT CCCCCCCCCCCCCCC	59.18	26388266
379	Acetylation	MVPLPMPKKLRFNIT CCCCCCCCCCCCCCC	59.18	2415153
390	Succinylation	FNITPEIKNDIEKAK CCCCHHHHHHHHHHH	47.08	26388266
390	Acetylation	FNITPEIKNDIEKAK CCCCHHHHHHHHHHH	47.08	24062335
395	Acetylation	EIKNDIEKAKQNLSI HHHHHHHHHHHHHHH	62.31	23864654
401	Phosphorylation	EKAKQNLSIMIQDLD HHHHHHHHHHHHHHH	20.05	21743459
449	S-nitrosylation	YRIYGQACATYESAS HHHHCHHHHCHHHCE	1.92	21278135
449	S-nitrosocysteine	YRIYGQACATYESAS HHHHCHHHHCHHHCE	1.92	-
485	Phosphorylation	FVKGMGDSTVPEQQK EECCCCCCCCCHHHH	26.10	24759943
609	Acetylation	RMAHYLEKALLDMRT HHHHHHHHHHHHHHH	41.56	23864654

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CACP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CACP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CACP_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CACP_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.