CACB2_HUMAN - dbPTM
CACB2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CACB2_HUMAN
UniProt AC Q08289
Protein Name Voltage-dependent L-type calcium channel subunit beta-2
Gene Name CACNB2
Organism Homo sapiens (Human).
Sequence Length 660
Subcellular Localization Cell membrane, sarcolemma
Peripheral membrane protein
Cytoplasmic side.
Protein Description The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting..
Protein Sequence MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
58PhosphorylationRFKGSDGSTSSDTTS
CCCCCCCCCCCCCCC		30.0624719451
60PhosphorylationKGSDGSTSSDTTSNS
CCCCCCCCCCCCCCC		28.1024076635
61PhosphorylationGSDGSTSSDTTSNSF
CCCCCCCCCCCCCCC		38.7824076635
64PhosphorylationGSTSSDTTSNSFVRQ
CCCCCCCCCCCCCCC		30.7924076635
73PhosphorylationNSFVRQGSADSYTSR
CCCCCCCCCCCCCCC		22.1426471730
76PhosphorylationVRQGSADSYTSRPSD
CCCCCCCCCCCCCCC		29.9923312004
77PhosphorylationRQGSADSYTSRPSDS
CCCCCCCCCCCCCCC		14.8523312004
78PhosphorylationQGSADSYTSRPSDSD
CCCCCCCCCCCCCCC		23.3923312004
79PhosphorylationGSADSYTSRPSDSDV
CCCCCCCCCCCCCCC		33.6823312004
82PhosphorylationDSYTSRPSDSDVSLE
CCCCCCCCCCCCCHH		48.9523312004
84PhosphorylationYTSRPSDSDVSLEED
CCCCCCCCCCCHHHH		44.2223312004
87PhosphorylationRPSDSDVSLEEDREA
CCCCCCCCHHHHHHH		34.7523312004
121PhosphorylationPVAFAVRTNVSYSAA
CEEEEEECCCCCCCC		33.1120067319
164 (in isoform 6)Phosphorylation-5.2310441130
165 (in isoform 10)Phosphorylation-53.6410441130
167 (in isoform 6)Phosphorylation-14.5129485707
175 (in isoform 6)Phosphorylation-37.1924275569
182 (in isoform 6)Phosphorylation-3.1024275569
190 (in isoform 10)Phosphorylation-14.2825262027
191 (in isoform 10)Phosphorylation-62.8725262027
191 (in isoform 9)Phosphorylation-62.8710441130
194 (in isoform 10)Phosphorylation-38.3425262027
197 (in isoform 10)Phosphorylation-34.1325262027
202 (in isoform 10)Phosphorylation-37.6325262027
204PhosphorylationSSKSGGNSSSSLGDI
CCCCCCCCCCCCCCC		34.57-
207PhosphorylationSGGNSSSSLGDIVPS
CCCCCCCCCCCCCCC		38.0224076635
216 (in isoform 9)Phosphorylation-41.0825262027
217 (in isoform 9)Phosphorylation-61.7125262027
218PhosphorylationIVPSSRKSTPPSSAI
CCCCCCCCCCCCCCC		45.0624076635
219PhosphorylationVPSSRKSTPPSSAID
CCCCCCCCCCCCCCE		42.1026471730
219 (in isoform 7)Phosphorylation-42.1010441130
219 (in isoform 8)Phosphorylation-42.1010441130
220 (in isoform 9)Phosphorylation-33.5925262027
222PhosphorylationSRKSTPPSSAIDIDA
CCCCCCCCCCCEECC		33.3426471730
222 (in isoform 7)Phosphorylation-33.3429485707
223 (in isoform 9)Phosphorylation-34.7125262027
223PhosphorylationRKSTPPSSAIDIDAT
CCCCCCCCCCEECCC		34.7124076635
228 (in isoform 9)Phosphorylation-34.0425262027
230 (in isoform 7)Phosphorylation-34.2324275569
237 (in isoform 7)Phosphorylation-43.9724275569
244 (in isoform 8)Phosphorylation-55.2325262027
245PhosphorylationDIPANHRSPKPSANS
CCCCCCCCCCCCCCC		29.7125002506
245 (in isoform 8)Phosphorylation-29.7125262027
248 (in isoform 8)Phosphorylation-41.9025262027
249PhosphorylationNHRSPKPSANSVTSP
CCCCCCCCCCCCCCC		46.3225002506
251 (in isoform 8)Phosphorylation-41.1525262027
252PhosphorylationSPKPSANSVTSPHSK
CCCCCCCCCCCCCCC		26.8725002506
254PhosphorylationKPSANSVTSPHSKEK
CCCCCCCCCCCCCCC		36.0425002506
255PhosphorylationPSANSVTSPHSKEKR
CCCCCCCCCCCCCCC		20.6125627689
256 (in isoform 8)Phosphorylation-26.8025262027
258PhosphorylationNSVTSPHSKEKRMPF
CCCCCCCCCCCCCCC		45.9925002506
269PhosphorylationRMPFFKKTEHTPPYD
CCCCCCCCCCCCCCC		33.3227251275
272PhosphorylationFFKKTEHTPPYDVVP
CCCCCCCCCCCCCCC		21.5226657352
275PhosphorylationKTEHTPPYDVVPSMR
CCCCCCCCCCCCCCC		23.67-
280PhosphorylationPPYDVVPSMRPVVLV
CCCCCCCCCCCEEEE		18.8025262027
290PhosphorylationPVVLVGPSLKGYEVT
CEEEECCCCCCCCHH		36.4624275569
294PhosphorylationVGPSLKGYEVTDMMQ
ECCCCCCCCHHHHHH		12.9724275569
297PhosphorylationSLKGYEVTDMMQKAL
CCCCCCHHHHHHHHH		13.2624275569
317PhosphorylationHRFEGRISITRVTAD
HHHCCCCEEEEEECC		19.2924719451
319PhosphorylationFEGRISITRVTADIS
HCCCCEEEEEECCHH		16.5823312004
322PhosphorylationRISITRVTADISLAK
CCEEEEEECCHHHHH		18.4723312004
326PhosphorylationTRVTADISLAKRSVL
EEEECCHHHHHHHHH		23.8729083192
464PhosphorylationLEAYWKATHPPSSSL
HHHHHHHHCCCCCCC		31.05-
482PhosphorylationLLSRTLATSSLPLSP
HHHCCCCCCCCCCCC		23.2029978859
483PhosphorylationLSRTLATSSLPLSPT
HHCCCCCCCCCCCCC		25.0329978859
484PhosphorylationSRTLATSSLPLSPTL
HCCCCCCCCCCCCCC		29.6529978859
488PhosphorylationATSSLPLSPTLASNS
CCCCCCCCCCCCCCC		17.5628348404
490PhosphorylationSSLPLSPTLASNSQG
CCCCCCCCCCCCCCC		31.4228348404
493PhosphorylationPLSPTLASNSQGSQG
CCCCCCCCCCCCCCC		39.8829978859
495PhosphorylationSPTLASNSQGSQGDQ
CCCCCCCCCCCCCCC		33.1629978859
498PhosphorylationLASNSQGSQGDQRTD
CCCCCCCCCCCCCCC		24.2929978859
507PhosphorylationGDQRTDRSAPIRSAS
CCCCCCCCCCCCCHH		41.0030622161
512PhosphorylationDRSAPIRSASQAEEE
CCCCCCCCHHHCCCC		32.7528857561
514PhosphorylationSAPIRSASQAEEEPS
CCCCCCHHHCCCCCC		31.0425554490
521PhosphorylationSQAEEEPSVEPVKKS
HHCCCCCCCCCCCCC		42.2530622161
528PhosphorylationSVEPVKKSQHRSSSS
CCCCCCCCCCCCCCC		26.0424719451
532PhosphorylationVKKSQHRSSSSAPHH
CCCCCCCCCCCCCCC		32.2329449344
533PhosphorylationKKSQHRSSSSAPHHN
CCCCCCCCCCCCCCC		28.4110567342
534PhosphorylationKSQHRSSSSAPHHNH
CCCCCCCCCCCCCCC		31.5910567342
535PhosphorylationSQHRSSSSAPHHNHR
CCCCCCCCCCCCCCC		48.0110567342
543PhosphorylationAPHHNHRSGTSRGLS
CCCCCCCCCCCCCCC		38.5824719451
545PhosphorylationHHNHRSGTSRGLSRQ
CCCCCCCCCCCCCCH		19.25-
546PhosphorylationHNHRSGTSRGLSRQE
CCCCCCCCCCCCCHH		28.0724719451
550O-linked_GlycosylationSGTSRGLSRQETFDS
CCCCCCCCCHHHCCC		34.4431492838
550PhosphorylationSGTSRGLSRQETFDS
CCCCCCCCCHHHCCC		34.44-
554PhosphorylationRGLSRQETFDSETQE
CCCCCHHHCCCCCHH		25.1422210691
574PhosphorylationYVEPKEDYSHDHVDH
CCCCCCCCCCCCHHH		14.7022468782
575PhosphorylationVEPKEDYSHDHVDHY
CCCCCCCCCCCHHHH		34.4622468782
605PhosphorylationSDHRHRESRHRSRDV
CHHHHHHHHHHHCCC		33.0927174698
609PhosphorylationHRESRHRSRDVDREQ
HHHHHHHHCCCCHHH		27.0629449344
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
219TPhosphorylationKinasePKA-FAMILY-GPS
219TPhosphorylationKinasePKA_GROUP-PhosphoELM
514SPhosphorylationKinasePKA-FAMILY-GPS
514SPhosphorylationKinasePKA_GROUP-PhosphoELM
533SPhosphorylationKinasePKA-FAMILY-GPS
533SPhosphorylationKinasePKA_GROUP-PhosphoELM
534SPhosphorylationKinasePKA-FAMILY-GPS
534SPhosphorylationKinasePKA_GROUP-PhosphoELM
554TPhosphorylationKinaseCAMK2DQ13557
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
554TPhosphorylation

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Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CACB2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CACB2_HUMAN !!
Drug and Disease Associations
Kegg Disease
H00728 Brugada syndrome (BRS)
OMIM Disease
611876Brugada syndrome 4 (BRGDA4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00381Amlodipine
DB04855Dronedarone
DB01023Felodipine
DB00270Isradipine
DB00653Magnesium Sulfate
DB00622Nicardipine
DB01115Nifedipine
DB06712Nilvadipine
DB00393Nimodipine
DB00401Nisoldipine
DB01054Nitrendipine
DB00421Spironolactone
DB00661Verapamil
Regulatory Network of CACB2_HUMAN

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Related Literatures of Post-Translational Modification

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