CACB1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CACB1_RAT
• UniProt AC: P54283
• Protein Name: Voltage-dependent L-type calcium channel subunit beta-1
• Gene Name: Cacnb1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 597
• Subcellular Localization: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
• Protein Description: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting..
• Protein Sequence: MVQKSGMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQTLRQNRLSSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQKSTEHVPPYDVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLAEVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSRTPPNPLLNRTMATAALAVSPAPVSNLQGPYLVSGDQPLDRATGEHASVHEYPGELGQPPGLYPSNHPPGRAGTLWALSRQDTFDADTPGSRNSVYTEPGDSCVDMETDPSEGPGPGDPAGGGTPPARQGSWEEEEDYEEEMTDNRNRGRNKARYCAEGGGPVLGRNKNELEGWGQGVYIR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	SGMSRGPYPPSQEIP CCCCCCCCCCHHCCC	30.51	26022182
15	Phosphorylation	SRGPYPPSQEIPMEV CCCCCCCHHCCCCCC	35.62	26022182
26	Phosphorylation	PMEVFDPSPQGKYSK CCCCCCCCCCCCCCC	31.53	26022182
41	Phosphorylation	RKGRFKRSDGSTSSD CCCCCCCCCCCCCCC	47.08	27097102
44	Phosphorylation	RFKRSDGSTSSDTTS CCCCCCCCCCCCCCC	30.06	27097102
45	Phosphorylation	FKRSDGSTSSDTTSN CCCCCCCCCCCCCCC	37.47	27097102
46	Phosphorylation	KRSDGSTSSDTTSNS CCCCCCCCCCCCCCC	28.10	27097102
47	Phosphorylation	RSDGSTSSDTTSNSF CCCCCCCCCCCCCCC	38.78	27097102
49	Phosphorylation	DGSTSSDTTSNSFVR CCCCCCCCCCCCCCC	33.79	16641100
51	Phosphorylation	STSSDTTSNSFVRQG CCCCCCCCCCCCCCC	32.35	16641100
53	Phosphorylation	SSDTTSNSFVRQGSA CCCCCCCCCCCCCCC	25.53	16641100
59	Phosphorylation	NSFVRQGSAESYTSR CCCCCCCCCCCCCCC	22.11	28432305
62	Phosphorylation	VRQGSAESYTSRPSD CCCCCCCCCCCCCCC	33.17	28432305
63	Phosphorylation	RQGSAESYTSRPSDS CCCCCCCCCCCCCCC	10.55	16641100
73	Phosphorylation	RPSDSDVSLEEDREA CCCCCCCCHHHHHHH	34.75	30240740
161	Phosphorylation	CEVGFIPSPVKLDSL CEEEEECCCCCHHHH	37.19	16406008
183	Phosphorylation	LRQNRLSSSKSGDNS HHHHCCCCCCCCCCC	46.51	25403869
184	Phosphorylation	RQNRLSSSKSGDNSS HHHCCCCCCCCCCCC	27.71	25403869
186	Phosphorylation	NRLSSSKSGDNSSSS HCCCCCCCCCCCCCC	54.01	27097102
190	Phosphorylation	SSKSGDNSSSSLGDV CCCCCCCCCCCCCCC	36.02	27097102
191	Phosphorylation	SKSGDNSSSSLGDVV CCCCCCCCCCCCCCC	30.15	27097102
192	Phosphorylation	KSGDNSSSSLGDVVT CCCCCCCCCCCCCCC	29.42	27097102
193	Phosphorylation	SGDNSSSSLGDVVTG CCCCCCCCCCCCCCC	38.02	27097102
205	Phosphorylation	VTGTRRPTPPASAKQ CCCCCCCCCCCCHHH	39.84	25403869
216	Phosphorylation	SAKQKQKSTEHVPPY CHHHHHCCCCCCCCC	36.21	25403869
217	Phosphorylation	AKQKQKSTEHVPPYD HHHHHCCCCCCCCCC	36.83	25403869
257	Acetylation	KALFDFLKHRFDGRI HHHHHHHHHHCCCCC	32.50	-
348	Phosphorylation	IVYIKITSPKVLQRL EEEEEECCHHHHHHH	26.62	16406008
495	Phosphorylation	AGTLWALSRQDTFDA HHHHHHHCCCCCCCC	21.83	28432305
499	Phosphorylation	WALSRQDTFDADTPG HHHCCCCCCCCCCCC	18.31	25403869
540	Phosphorylation	GDPAGGGTPPARQGS CCCCCCCCCCCCCCC	29.40	30240740
547	Phosphorylation	TPPARQGSWEEEEDY CCCCCCCCCCCCHHH	23.99	30240740

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
161	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
161	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
348	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
348	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
499	T	Phosphorylation	Kinase	CAMK2D	P15791	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CACB1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CACB1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NED4L_HUMAN	NEDD4L	physical	19953087

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.