CABYR_HUMAN - dbPTM
CABYR_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CABYR_HUMAN
UniProt AC O75952
Protein Name Calcium-binding tyrosine phosphorylation-regulated protein
Gene Name CABYR
Organism Homo sapiens (Human).
Sequence Length 493
Subcellular Localization Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Localized to fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella.
Isoform 1: Nucleus. Cytoplasm. Cell projection, cilium, fla
Protein Description May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium..
Protein Sequence MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVKQFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGAIKIGSEKSLHLEVEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLTAPEIEPEGESTAE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MISSKPRLVVP
----CCCCCCCEECC		35.44-
16PhosphorylationVVPYGLKTLLEGISR
ECCCCHHHHHHHHHH		41.43-
22PhosphorylationKTLLEGISRAVLKTN
HHHHHHHHHHHHHHC		25.6630622161
28PhosphorylationISRAVLKTNPSNINQ
HHHHHHHHCCCHHHH		48.4725693802
31PhosphorylationAVLKTNPSNINQFAA
HHHHHCCCHHHHHHH		53.0330622161
40PhosphorylationINQFAAAYFQELTMY
HHHHHHHHHHHHHCC		10.89-
40 (in isoform 2)Phosphorylation-10.89-
47PhosphorylationYFQELTMYRGNTTMD
HHHHHHCCCCCCCCC		15.33-
47 (in isoform 2)Phosphorylation-15.33-
51PhosphorylationLTMYRGNTTMDIKDL
HHCCCCCCCCCHHHH		26.73-
51 (in isoform 5)Phosphorylation-26.7328348404
52PhosphorylationTMYRGNTTMDIKDLV
HCCCCCCCCCHHHHH		19.49-
52 (in isoform 5)Phosphorylation-19.4928348404
53 (in isoform 5)Phosphorylation-4.7628348404
56 (in isoform 5)Phosphorylation-40.5228348404
57 (in isoform 5)Phosphorylation-57.9628348404
61 (in isoform 5)Phosphorylation-33.3128348404
64 (in isoform 5)Phosphorylation-38.1928348404
69 (in isoform 5)Phosphorylation-60.0330622161
71PhosphorylationQIKVEKWSEGTTPQK
HHHCEECCCCCCCHH		36.9030622161
74PhosphorylationVEKWSEGTTPQKKLE
CEECCCCCCCHHHHH		31.1130622161
75PhosphorylationEKWSEGTTPQKKLEC
EECCCCCCCHHHHHH		34.2830622161
89PhosphorylationCLKEPGKTSVESKVP
HHCCCCCCCCCCCCC		43.8730622161
90PhosphorylationLKEPGKTSVESKVPT
HCCCCCCCCCCCCCC		27.6330622161
93PhosphorylationPGKTSVESKVPTQME
CCCCCCCCCCCCCCC		36.4830622161
97PhosphorylationSVESKVPTQMEKSTD
CCCCCCCCCCCCCCC		43.4630622161
102PhosphorylationVPTQMEKSTDTDEDN
CCCCCCCCCCCCCCC		20.4330622161
103PhosphorylationPTQMEKSTDTDEDNV
CCCCCCCCCCCCCCC		54.7222210691
105PhosphorylationQMEKSTDTDEDNVTR
CCCCCCCCCCCCCCE		41.1822210691
111PhosphorylationDTDEDNVTRTEYSDK
CCCCCCCCEEECCCC		37.8230622161
113PhosphorylationDEDNVTRTEYSDKTT
CCCCCCEEECCCCCC		29.8822210691
114 (in isoform 5)Phosphorylation-39.4930622161
116PhosphorylationNVTRTEYSDKTTQFP
CCCEEECCCCCCCCC		26.8030622161
119PhosphorylationRTEYSDKTTQFPSVY
EEECCCCCCCCCEEE		30.7130622161
120PhosphorylationTEYSDKTTQFPSVYA
EECCCCCCCCCEEEE		33.6730622161
124PhosphorylationDKTTQFPSVYAVPGT
CCCCCCCEEEECCCC		29.1130622161
126PhosphorylationTTQFPSVYAVPGTEQ
CCCCCEEEECCCCCC		13.2530622161
126 (in isoform 5)Phosphorylation-13.2525693802
128 (in isoform 5)Phosphorylation-2.1625693802
131PhosphorylationSVYAVPGTEQTEAVG
EEEECCCCCCCEECC		20.8928348404
134PhosphorylationAVPGTEQTEAVGGLS
ECCCCCCCEECCCCC		21.4930278072
141PhosphorylationTEAVGGLSSKPATPK
CEECCCCCCCCCCCC		39.3230278072
142PhosphorylationEAVGGLSSKPATPKT
EECCCCCCCCCCCCC		47.9330278072
146PhosphorylationGLSSKPATPKTTTPP
CCCCCCCCCCCCCCC		33.5730278072
148 (in isoform 5)Phosphorylation-54.9030622161
149PhosphorylationSKPATPKTTTPPSSP
CCCCCCCCCCCCCCC		36.7928348404
149 (in isoform 3)Phosphorylation-36.7928348404
149 (in isoform 5)Phosphorylation-36.7930622161
150PhosphorylationKPATPKTTTPPSSPP
CCCCCCCCCCCCCCC		43.3528348404
150 (in isoform 3)Phosphorylation-43.3528348404
151PhosphorylationPATPKTTTPPSSPPP
CCCCCCCCCCCCCCC		38.1325693802
151 (in isoform 3)Phosphorylation-38.1328348404
154PhosphorylationPKTTTPPSSPPPTAV
CCCCCCCCCCCCCCC		57.5925693802
154 (in isoform 3)Phosphorylation-57.5928348404
155PhosphorylationKTTTPPSSPPPTAVS
CCCCCCCCCCCCCCC		47.3914702039
155 (in isoform 3)Phosphorylation-47.3928348404
157 (in isoform 5)Phosphorylation-40.6022210691
158 (in isoform 5)Phosphorylation-36.0522210691
159PhosphorylationPPSSPPPTAVSPEFA
CCCCCCCCCCCCCCC		45.5225693802
159 (in isoform 3)Phosphorylation-45.5228348404
162PhosphorylationSPPPTAVSPEFAYVP
CCCCCCCCCCCCCCC		19.0930622161
162 (in isoform 3)Phosphorylation-19.0928348404
167PhosphorylationAVSPEFAYVPADPAQ
CCCCCCCCCCCCHHH		16.5830622161
167 (in isoform 3)Phosphorylation-16.5830622161
167 (in isoform 5)Phosphorylation-16.5825693802
184PhosphorylationAQMLGKVSSIHSDQS
HHHHHCHHHCCCCCC		27.3625693802
185PhosphorylationQMLGKVSSIHSDQSD
HHHHCHHHCCCCCCC		27.5825693802
185 (in isoform 5)Phosphorylation-27.5822210691
187 (in isoform 4)Phosphorylation-27.5417287340
187 (in isoform 5)Phosphorylation-27.5422210691
188PhosphorylationGKVSSIHSDQSDVLM
HCHHHCCCCCCCEEE		35.3625693802
188 (in isoform 4)Phosphorylation-35.3617287340
191PhosphorylationSSIHSDQSDVLMVDV
HHCCCCCCCEEEEEE		34.3825693802
192 (in isoform 5)Phosphorylation-31.7522210691
200PhosphorylationVLMVDVATSMPVVIK
EEEEEECCCCCEEEE		25.9625693802
201PhosphorylationLMVDVATSMPVVIKE
EEEEECCCCCEEEEE		16.0225693802
207 (in isoform 5)Phosphorylation-40.8422210691
211PhosphorylationVVIKEVPSSEAAEDV
EEEEECCCCHHHHHC		46.0930622161
211 (in isoform 5)Phosphorylation-46.0925693802
212PhosphorylationVIKEVPSSEAAEDVM
EEEECCCCHHHHHCC		25.7830622161
212 (in isoform 3)Phosphorylation-25.7830622161
213 (in isoform 5)Phosphorylation-57.1230622161
221 (in isoform 5)Phosphorylation-5.8125693802
224 (in isoform 3)Phosphorylation-5.3525693802
226 (in isoform 3)Phosphorylation-6.1425693802
227PhosphorylationVAAPLVCSGKVLEVQ
CHHHEEECCCEEEEE		33.8830622161
230 (in isoform 5)Phosphorylation-6.6822617229
235 (in isoform 5)Phosphorylation-5.4325693802
239PhosphorylationEVQVVNQTSVHVDLG
EEEEEECEEEEEECC		27.7530622161
240PhosphorylationVQVVNQTSVHVDLGS
EEEEECEEEEEECCC		10.6412509440
246 (in isoform 3)Phosphorylation-21.5530622161
247PhosphorylationSVHVDLGSQPKENEA
EEEEECCCCCCCCCC		51.0825693802
247 (in isoform 3)Phosphorylation-51.0830622161
247 (in isoform 5)Phosphorylation-51.0817287340
248 (in isoform 5)Phosphorylation-51.8117287340
255 (in isoform 3)Phosphorylation-33.3422210691
256 (in isoform 3)Phosphorylation-43.9922210691
265 (in isoform 3)Phosphorylation-46.2325693802
283 (in isoform 3)Phosphorylation-23.9022210691
285 (in isoform 3)Phosphorylation-4.8822210691
290 (in isoform 3)Phosphorylation-9.6722210691
305 (in isoform 3)Phosphorylation-12.5822210691
309 (in isoform 3)Phosphorylation-1.5125693802
311 (in isoform 3)Phosphorylation-53.4030622161
319 (in isoform 3)Phosphorylation-18.3925693802
328 (in isoform 3)Phosphorylation-59.3822617229
333 (in isoform 3)Phosphorylation-35.4425693802
339PhosphorylationQSKENEQSPRVSPKS
HHHCCCCCCCCCHHH		14.4312509440
343PhosphorylationNEQSPRVSPKSVVEK
CCCCCCCCHHHHHHH		28.0830622161
345 (in isoform 3)Phosphorylation-48.6617287340
346PhosphorylationSPRVSPKSVVEKTTS
CCCCCHHHHHHHHCC		34.4817287340
346 (in isoform 3)Phosphorylation-34.4817287340
351PhosphorylationPKSVVEKTTSGMSKK
HHHHHHHHCCCCCHH		16.8230622161
352PhosphorylationKSVVEKTTSGMSKKS
HHHHHHHCCCCCHHH		34.0630622161
353PhosphorylationSVVEKTTSGMSKKSV
HHHHHHCCCCCHHHH		37.4230622161
356PhosphorylationEKTTSGMSKKSVESV
HHHCCCCCHHHHHHE		40.2230622161
359PhosphorylationTSGMSKKSVESVKLA
CCCCCHHHHHHEEHH		34.5512509440
362PhosphorylationMSKKSVESVKLAQLE
CCHHHHHHEEHHHHH		23.5412509440
364AcetylationKKSVESVKLAQLEEN
HHHHHHEEHHHHHHH		47.5925038526
374PhosphorylationQLEENAKYSSVYMEA
HHHHHHCCCEEEEHH		12.0830622161
375PhosphorylationLEENAKYSSVYMEAE
HHHHHCCCEEEEHHH		16.7830622161
376PhosphorylationEENAKYSSVYMEAEA
HHHHCCCEEEEHHHH		17.7430622161
378PhosphorylationNAKYSSVYMEAEATA
HHCCCEEEEHHHHHH		7.3830622161
384PhosphorylationVYMEAEATALLSDTS
EEEHHHHHHHHCCCC		14.8925693802
388PhosphorylationAEATALLSDTSLKGQ
HHHHHHHCCCCCCCC		39.4330622161
390PhosphorylationATALLSDTSLKGQPE
HHHHHCCCCCCCCCC		32.3630622161
391PhosphorylationTALLSDTSLKGQPEV
HHHHCCCCCCCCCCC		32.8330622161
413PhosphorylationEGAIKIGSEKSLHLE
CCCEEECCCCCEEEE		45.3712509440
461PhosphorylationEAAEAVHSGTSVKSS
HHHHHHHCCCCCCCC		36.8512509440
463PhosphorylationAEAVHSGTSVKSSSG
HHHHHCCCCCCCCCC		33.1030622161
464PhosphorylationEAVHSGTSVKSSSGP
HHHHCCCCCCCCCCC		30.9530622161
467PhosphorylationHSGTSVKSSSGPFPP
HCCCCCCCCCCCCCC		27.8125693802
468PhosphorylationSGTSVKSSSGPFPPA
CCCCCCCCCCCCCCC		33.3325693802
469PhosphorylationGTSVKSSSGPFPPAP
CCCCCCCCCCCCCCC		58.5412509440
480PhosphorylationPPAPEGLTAPEIEPE
CCCCCCCCCCCCCCC		51.5325693802
490PhosphorylationEIEPEGESTAE----
CCCCCCCCCCC----		43.7225693802
491PhosphorylationIEPEGESTAE-----
CCCCCCCCCC-----		30.4225693802
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
151TPhosphorylationKinaseGSK3BP49841
PSP
155SPhosphorylationKinaseGSK3BP49841
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CABYR_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CABYR_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CABYR_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CABYR_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of capacitated human sperm. Evidence oftyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation.";
Ficarro S., Chertihin O., Westbrook V.A., White F., Jayes F.,Kalab P., Marto J.A., Shabanowitz J., Herr J.C., Hunt D.F.,Visconti P.E.;
J. Biol. Chem. 278:11579-11589(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240; SER-359; SER-362;SER-413; SER-461 AND SER-469, AND MASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory