dbPTM

CA2D1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CA2D1_MOUSE
UniProt AC	O08532
Protein Name	Voltage-dependent calcium channel subunit alpha-2/delta-1
Gene Name	Cacna2d1
Organism	Mus musculus (Mouse).
Sequence Length	1103
Subcellular Localization	Membrane Single-pass type I membrane protein .
Protein Description	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity)..
Protein Sequence	MAAGCLLALTLTLFQSGLIGPSSEEPFPSPVTIKSWVDKMQEDLVTLAKTASGVTQLADIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLAMEAEKVQAAHQWREDFASNEVVYYNAKDDLDPERNESEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKRNRDEDPTLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNVTGQSENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRPNVQNPKSQEPVTLDFLDAELENEIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTFIAPREYCNDLKPSDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRILLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVELYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSMMRHLVNISLYAFNKSYDYQSVCDPGAAPKQGAGHRSAYVPSIADILQIGWWATAAAWSILQQLLLSLTFPRLLEAVEMEEDDFTASLSKQSCITEQTQYFFKNDTKSFSGLLDCGNCSRIFHVEKLMNTNLVFIMVESKGTCPCDTRLLMQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWSIFGLQFILLWLVSGSRHYLL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	EPFPSPVTIKSWVDK CCCCCCCCHHHHHHH	26.52	24759943
91	Phosphorylation	RDIEKLLSNRSKALV HHHHHHHCCHHHHHH	40.40	-
92	N-linked_Glycosylation	DIEKLLSNRSKALVR HHHHHHCCHHHHHHH	52.82	-
94	Phosphorylation	EKLLSNRSKALVRLA HHHHCCHHHHHHHHH	26.91	-
119	Phosphorylation	QWREDFASNEVVYYN HHHHHHHCCCEEEEE	33.25	-
136	N-linked_Glycosylation	DDLDPERNESEPGSQ CCCCCCCCCCCCCCC	56.32	19656770
184	N-linked_Glycosylation	TIVLNELNWTSALDE EEEEECCCHHHHHHH	33.53	-
323	N-linked_Glycosylation	KVLKDAVNNITAKGI HHHHHHHHHCCCCCC	35.59	19656770
324	N-linked_Glycosylation	VLKDAVNNITAKGIT HHHHHHHHCCCCCCC	26.79	19656770
348	N-linked_Glycosylation	FEQLLNYNVSRANCN HHHHHCCCCCCCCCC	24.98	-
375	Acetylation	RAQEIFAKYNKDKKV HHHHHHHHHCCCCCE	38.31	7718825
380	Acetylation	FAKYNKDKKVRVFTF HHHHCCCCCEEEEEE	55.57	7718835
381	Acetylation	AKYNKDKKVRVFTFS HHHCCCCCEEEEEEE	45.46	7718845
583	Phosphorylation	NKMIDGESGEKTFRT CEEECCCCCHHHHHH	58.75	28464351
613	N-linked_Glycosylation	TYTWTPVNGTDYSLA EEEEEECCCCCCEEE	49.18	-
640	Phosphorylation	AKLEETITQARYSET HHHHHHHHHHHHCCC	24.48	29514104
772	N-linked_Glycosylation	KRSLDNDNYVFTAPY CHHCCCCCEEEEECC	40.91	19656770
781	N-linked_Glycosylation	VFTAPYFNKSGPGAY EEEECCCCCCCCCHH	31.57	19656770
888	N-linked_Glycosylation	SMMRHLVNISLYAFN HHHHHHHHCHHEECC	25.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CA2D1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CA2D1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CA2D1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CA2D1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CA2D1_MOUSE

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-136 AND ASN-781, AND MASSSPECTROMETRY.	19349973 [Abstract]
"The mouse C2C12 myoblast cell surface N-linked glycoproteome:identification, glycosite occupancy, and membrane orientation."; Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I.,Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E.,Wollscheid B.; Mol. Cell. Proteomics 8:2555-2569(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-136; ASN-323; ASN-324;ASN-772 AND ASN-781, AND MASS SPECTROMETRY.	19656770 [Abstract]