dbPTM

C3390_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	C3390_DROME
UniProt AC	Q7KT91
Protein Name	Non-lysosomal glucosylceramidase
Gene Name	CG33090
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	948
Subcellular Localization	Cell membrane Single-pass membrane protein .
Protein Description	Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide..
Protein Sequence	MAEPLAVETKPLSNGNANGNAVGIAESASAVFQEKLKLQQQEESNEIAAVPKYGLKLKFDHVWPEKRIQNVRASIRQTLPMVPLVCRYAAYYWKVSREGRRVYMDYYYMENGKQIYGVPIGGIGGGTIGRGYAGEFCRFQMRPGIYEYNVVLANQFIVTIKDPKGCTIFQSLLSKCSTRDKTSDPDGDPDGERTKCQLPNCSSRAKQPLSAWHSNIEDTRCSYTGLYPRSWTEYDLSHYGVRLTCRQVSPVIPHEYRESSLPCAVFVWSVENVCDQERKVSITFTFKNGTGNKKQDAEGGAESQLISEGNAKGVSIRQKISEMPCSYNLACRVLPEISITRCPQFDPAGNGEQLWAQLKEHGQLSEHPTSEALKTKDIGVAVCGQVALKPMASHDLEFVLAWDMPKIQFPRKMQTHTRYYTKYFDDSGDSGPRICEYALRQYSTWERLIDAWQRPILNDETLPDWYKCAIFNQLYFISDGGTIWLKCDSSLGKELAYDDPRLAYGRFGYLEGHEYRMYNTYDVHFYASPALAHLWPNLQVSLQYDFKDAIAAELNDTRKMLYDGKVMPRKVKNCVPHDLGDPDEEPFTLINCYNIHDVNDWKDLNTKFVLQVYRDYYVLNELAQAQSDNASKFSSIEFIDKESLYELYSQDNKRKNSADEKQQNRKSASMYINETNGKVYLMDAIGYLKAMYASCKAIMERTIEYDKDNDGLIENTKMPDQTYDSWVMDGPSAYCSGLWLAALQAMSAMATILDQPNDCLRYQDILEKGKRSLEEKLWNGSYYRFDLSHSHRDTIMADQLCGHWYLKSCGFDYEIYPKENVRTALKRIYDNNVMGFHEGNIGAANGFIANASEPTKPGHVDNSNIQAEEVWPGVVYALAATMIQEGMFEEAFQTAGGMYKTLSQRIGMNFETPEALYGEKRYRSIGYMRPLSIWSMQVALERRRAQRD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
200	N-linked_Glycosylation	RTKCQLPNCSSRAKQ CCCCCCCCCCHHCCC	47.06	-
214	Phosphorylation	QPLSAWHSNIEDTRC CCCCHHHCCCCCCCC	28.89	18327897
288	N-linked_Glycosylation	SITFTFKNGTGNKKQ EEEEEEECCCCCCEE	49.41	-
555	N-linked_Glycosylation	DAIAAELNDTRKMLY HHHHHHCCCHHHHHH	39.86	-
627	Phosphorylation	NELAQAQSDNASKFS HHHHHHHCCCCHHCC	35.53	19429919
629	N-linked_Glycosylation	LAQAQSDNASKFSSI HHHHHCCCCHHCCCE	51.89	-
631	Phosphorylation	QAQSDNASKFSSIEF HHHCCCCHHCCCEEE	40.25	19429919
635	Phosphorylation	DNASKFSSIEFIDKE CCCHHCCCEEEECHH	29.30	19429919
643	Phosphorylation	IEFIDKESLYELYSQ EEEECHHHHHHHHCC	41.83	19429919
645	Phosphorylation	FIDKESLYELYSQDN EECHHHHHHHHCCCC	17.11	19429919
667	Phosphorylation	EKQQNRKSASMYINE HHHHHHHHHHHEEEC	23.49	22817900
669	Phosphorylation	QQNRKSASMYINETN HHHHHHHHHEEECCC	21.14	18327897
673	N-linked_Glycosylation	KSASMYINETNGKVY HHHHHEEECCCCEEE	32.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of C3390_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of C3390_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of C3390_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of C3390_DROME !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of C3390_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214; SER-667 ANDSER-669, AND MASS SPECTROMETRY.	18327897 [Abstract]