C2C4C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: C2C4C_HUMAN
• UniProt AC: Q8TF44
• Protein Name: C2 calcium-dependent domain-containing protein 4C
• Gene Name: C2CD4C
• Organism: Homo sapiens (Human).
• Sequence Length: 421
• Protein Sequence: MRKTNMWFLERLRGSGENGAARGVGSEAGDKASKGPLYSNVLTPDKIPDFFIPPKLPSGPAEGEGQAALGPSTSEQNLASAAPRQTPRSPRLPAKLAAESKSLLKAATRHVIQIESAEDWLSEEATDADPQAQGAMSLPSVPKAQTSYGFAMLAESPHTRRKESLFHSEHGALAQVGSPGAGRRRAAAKANGGDGGPREAGGALMSPGRYFSGGESDTGSSAESSPFGSPLLSRSVSLLKGFAQDSQAKVSQLRHSVGRHGSLSADDSTPDASPGSRRRLTRRAPPEPGPESGQARGEHTVHVGPRGSVRLLAEYEAGQARLRVHLLAAEGLYDRLCDARSINCCVGLCLVPGKLQKQRSTIVKNSRRPVFNEDFFFDGLGPASVRKLALRIKVVNKGSSLKRDTLLGEKELPLTSLLPFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Methylation	SGENGAARGVGSEAG CCCCCCCCCCCCCCC	39.53	-
31	Ubiquitination	VGSEAGDKASKGPLY CCCCCCCCCCCCCCC	54.35	30230243
33	Phosphorylation	SEAGDKASKGPLYSN CCCCCCCCCCCCCCC	43.83	29083192
38	Phosphorylation	KASKGPLYSNVLTPD CCCCCCCCCCCCCCC	11.00	21945579
39	Phosphorylation	ASKGPLYSNVLTPDK CCCCCCCCCCCCCCC	28.31	21945579
43	Phosphorylation	PLYSNVLTPDKIPDF CCCCCCCCCCCCCCC	25.76	29083192
58	Phosphorylation	FIPPKLPSGPAEGEG CCCCCCCCCCCCCCC	68.77	29978859
72	Phosphorylation	GQAALGPSTSEQNLA CCCCCCCCHHHHHHH	42.65	29978859
73	Phosphorylation	QAALGPSTSEQNLAS CCCCCCCHHHHHHHH	39.14	26657352
74	Phosphorylation	AALGPSTSEQNLASA CCCCCCHHHHHHHHH	41.33	29978859
80	Phosphorylation	TSEQNLASAAPRQTP HHHHHHHHHCCCCCC	28.29	29978859
86	Phosphorylation	ASAAPRQTPRSPRLP HHHCCCCCCCCCCHH	23.19	27251275
89	Phosphorylation	APRQTPRSPRLPAKL CCCCCCCCCCHHHHH	18.64	21406692
100	Phosphorylation	PAKLAAESKSLLKAA HHHHHHHHHHHHHHH	23.87	21406692
102	Phosphorylation	KLAAESKSLLKAATR HHHHHHHHHHHHHHH	48.49	24719451
108	Phosphorylation	KSLLKAATRHVIQIE HHHHHHHHHHEEEEE	26.60	24702127
137	Phosphorylation	PQAQGAMSLPSVPKA HHHCCCCCCCCCCHH	36.27	27067055
140	Phosphorylation	QGAMSLPSVPKAQTS CCCCCCCCCCHHHCC	57.24	27067055
146	Phosphorylation	PSVPKAQTSYGFAML CCCCHHHCCCCEEEC	28.86	23312004
147	Phosphorylation	SVPKAQTSYGFAMLA CCCHHHCCCCEEECC	15.92	29449344
148	Phosphorylation	VPKAQTSYGFAMLAE CCHHHCCCCEEECCC	21.46	28122231
156	Phosphorylation	GFAMLAESPHTRRKE CEEECCCCCCCCCHH	19.17	30266825
159	Phosphorylation	MLAESPHTRRKESLF ECCCCCCCCCHHHHH	35.24	30266825
164	Phosphorylation	PHTRRKESLFHSEHG CCCCCHHHHHCCCCC	39.09	23403867
168	Phosphorylation	RKESLFHSEHGALAQ CHHHHHCCCCCCHHC	24.77	23403867
178	Phosphorylation	GALAQVGSPGAGRRR CCHHCCCCCCHHHHH	22.70	22617229
206	O-linked_Glycosylation	EAGGALMSPGRYFSG CCCCCCCCCCCCCCC	25.67	29237092
206	Phosphorylation	EAGGALMSPGRYFSG CCCCCCCCCCCCCCC	25.67	28985074
210	Phosphorylation	ALMSPGRYFSGGESD CCCCCCCCCCCCCCC	14.17	23532336
221	Phosphorylation	GESDTGSSAESSPFG CCCCCCCCCCCCCCC	37.08	23532336
229	Phosphorylation	AESSPFGSPLLSRSV CCCCCCCCCHHHHHH	16.86	27251275
237	Phosphorylation	PLLSRSVSLLKGFAQ CHHHHHHHHHHHHHC	29.27	24719451
240	Methylation	SRSVSLLKGFAQDSQ HHHHHHHHHHHCCHH	58.22	-
251	Phosphorylation	QDSQAKVSQLRHSVG CCHHHHHHHHHHCCC	23.84	29449344
256	Phosphorylation	KVSQLRHSVGRHGSL HHHHHHHCCCCCCCC	21.60	29449344
262	Phosphorylation	HSVGRHGSLSADDST HCCCCCCCCCCCCCC	17.02	28985074
264	Phosphorylation	VGRHGSLSADDSTPD CCCCCCCCCCCCCCC	31.20	29523821
268	Phosphorylation	GSLSADDSTPDASPG CCCCCCCCCCCCCCC	42.24	27050516
269	Phosphorylation	SLSADDSTPDASPGS CCCCCCCCCCCCCCC	31.98	29523821
273	Phosphorylation	DDSTPDASPGSRRRL CCCCCCCCCCCCCCC	36.85	25554490
276	Phosphorylation	TPDASPGSRRRLTRR CCCCCCCCCCCCCCC	26.46	22496350
405	Phosphorylation	GSSLKRDTLLGEKEL CCCCCCCCCCCCCCC	28.10	19690332
415	Phosphorylation	GEKELPLTSLLPFL- CCCCCCHHHCCCCC-	18.52	19690332
416	Phosphorylation	EKELPLTSLLPFL-- CCCCCHHHCCCCC--	35.28	19690332

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of C2C4C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of C2C4C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of C2C4C_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of C2C4C_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.