BTBDI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BTBDI_HUMAN
• UniProt AC: B2RXH4
• Protein Name: BTB/POZ domain-containing protein 18 {ECO:0000305}
• Gene Name: BTBD18 {ECO:0000312|HGNC:HGNC:37214}
• Organism: Homo sapiens (Human).
• Sequence Length: 712
• Subcellular Localization: Nucleus .
• Protein Description: Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene..
• Protein Sequence: MCSPASPKILYRNPRFLRLAFLQLHHQQQSDVFCDVLLQAEGEAVPAHCCILSACSPFFTERLERERPAQGGKVVLELGGLKISTLRKLVDFLYTSEMEVSQEEAQDVLSAARQLRVSELESLQLEGGKLVKAPQGRRLNRECLQPTSAAPISARVVTPSHHPHTPLPTNQTPCPLGAIRLKSLGKEEGPQENNRQNADNLSGTLLLKRKARACPTPQEKNSSPSSHSQEPRENKNDTALDPTVLSPPSLYPSVDKHLLPRKIRLSRSKPSPGICTSKPSSILSGSSSVPATPGRRLWRQRSVNKETPEDKPKPGRASPLQSTPNPSGLGKTGGSRKRSPEVRAPNSDSAEEGQVGRVKLRKIVNGTCWEVVQETPLKNTQDSPQIPDPGGDFQEPSGTQPFSSNEQEMSPTRTELCQDSPMCTKLQDILVSASHSPDHPVVKSEFESSPELVEKEPMLAIDCREPYAFDTALLEQPCEAEEYRITSAAATSELEEILDFMLCGSDIEPPIGSLESPGAEGCRTPTYHLTETGKNWIEGEEWCLPDMELWPRELTELEKEPAGENRGPTELLSPLVMPSEVSEVLSVGGRWTPDLEITSSQPLDGQEDKLLHVSSLDTPQRSYGDLSPPCSNWVETGLEVSLTTDELLYPSPKAGKEVSGHSELLGSLPASSEEEEIDVVDWTAEGRLVPTTVPSVWPDPSSESETEVDILT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
186	Ubiquitination	IRLKSLGKEEGPQEN CCHHHCCCCCCCCCC	58.86	30230243
202	Phosphorylation	RQNADNLSGTLLLKR CCCCCCCCHHHHHHH	35.67	22210691
204	Phosphorylation	NADNLSGTLLLKRKA CCCCCCHHHHHHHHH	15.74	22210691
246	Phosphorylation	ALDPTVLSPPSLYPS CCCCCCCCCHHHCCC	30.35	24719451
253	Phosphorylation	SPPSLYPSVDKHLLP CCHHHCCCCCHHHCC	29.41	24719451
280	Phosphorylation	GICTSKPSSILSGSS CCCCCCCCHHCCCCC	33.47	28111955
281	Phosphorylation	ICTSKPSSILSGSSS CCCCCCCHHCCCCCC	35.76	28111955
284	Phosphorylation	SKPSSILSGSSSVPA CCCCHHCCCCCCCCC	34.65	28111955
286	Phosphorylation	PSSILSGSSSVPATP CCHHCCCCCCCCCCC	18.96	28111955
287	Phosphorylation	SSILSGSSSVPATPG CHHCCCCCCCCCCCC	38.59	28111955
288	Phosphorylation	SILSGSSSVPATPGR HHCCCCCCCCCCCCH	33.54	28111955
292	Phosphorylation	GSSSVPATPGRRLWR CCCCCCCCCCHHHHH	21.87	28111955
335	Phosphorylation	GLGKTGGSRKRSPEV CCCCCCCCCCCCCCC	35.65	19664995
375	Phosphorylation	CWEVVQETPLKNTQD CCEEHCCCCCCCCCC	19.48	24275569
380	Phosphorylation	QETPLKNTQDSPQIP CCCCCCCCCCCCCCC	31.97	24275569
420	Phosphorylation	RTELCQDSPMCTKLQ HHHHHCCCCCHHHHH	6.67	-
486	Phosphorylation	EAEEYRITSAAATSE CCCCCCCCCHHHCHH	11.87	-
487	Phosphorylation	AEEYRITSAAATSEL CCCCCCCCHHHCHHH	17.34	-
671	Phosphorylation	LLGSLPASSEEEEID HCCCCCCCCCCCCCC	36.02	-
672	Phosphorylation	LGSLPASSEEEEIDV CCCCCCCCCCCCCCE	51.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BTBDI_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BTBDI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BTBDI_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of BTBDI_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.