BTBD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BTBD1_MOUSE
• UniProt AC: P58544
• Protein Name: BTB/POZ domain-containing protein 1
• Gene Name: Btbd1
• Organism: Mus musculus (Mouse).
• Sequence Length: 488
• Subcellular Localization: Cytoplasm . Localizes to punctate or elongated cytoplasmic bodies.
• Protein Description: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism. [PubMed: 15486563]
• Protein Sequence: MASLGSAAAGEPATGAEAEPGPPAPPPPPPPPPAPSPSALGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTVDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAIVRWAEAECQRQQLAVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIRFTVNRRISVVGFGLYGSIHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFKEPIEILPNVCYTACATLKGPDSHYGTKGLKKVVHETPAASKTVFLFFSSPGNNNGTSIEDGQIPEIIFYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASLGSAAAG -----CCCCCCCCCC	31.78	25293948
6	Phosphorylation	--MASLGSAAAGEPA --CCCCCCCCCCCCC	21.74	25293948
14	Phosphorylation	AAAGEPATGAEAEPG CCCCCCCCCCCCCCC	47.87	25293948
36	Phosphorylation	PPPPPAPSPSALGPL CCCCCCCCCHHCCCC	33.33	25293948
38	Phosphorylation	PPPAPSPSALGPLLP CCCCCCCHHCCCCCC	40.23	25293948
58	Ubiquitination	LYNWQATKASLKERF CCCHHHCHHHHHHHH	38.71	22790023
83	Ubiquitination	DVRFVLGKGRGAAAA CCHHHHCCCCCHHHC	41.07	27667366
85	Methylation	RFVLGKGRGAAAAGG HHHHCCCCCHHHCCC	34.75	-
143	Phosphorylation	LALLRFLYSDEVQIG HHHHHHHHCCCCCCC	16.03	25777480
144	Phosphorylation	ALLRFLYSDEVQIGP HHHHHHHCCCCCCCH	29.46	25777480
153	Phosphorylation	EVQIGPETVMTTLYT CCCCCHHHHHHHHHH	20.79	25777480
156	Phosphorylation	IGPETVMTTLYTAKK CCHHHHHHHHHHHHH	14.87	25777480
157	Phosphorylation	GPETVMTTLYTAKKY CHHHHHHHHHHHHHH	10.32	25777480
159	Phosphorylation	ETVMTTLYTAKKYAV HHHHHHHHHHHHHHH	11.54	25777480
160	Phosphorylation	TVMTTLYTAKKYAVP HHHHHHHHHHHHHHH	34.80	25777480
276	Ubiquitination	NKQKVLGKALSLIRF CHHHHHHHHHHHHHH	41.83	-
394	Ubiquitination	QIIEYEKKQTLGQND EEEEEECCCCCCCCC	36.25	22790023
430	Phosphorylation	ILPNVCYTACATLKG ECCCEEEEHHHHCCC	15.33	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BTBD1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BTBD1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BTBD1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BTBD1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.