dbPTM

BRWD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BRWD1_MOUSE
UniProt AC	Q921C3
Protein Name	Bromodomain and WD repeat-containing protein 1
Gene Name	Brwd1
Organism	Mus musculus (Mouse).
Sequence Length	2304
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	May be a transcriptional activator. May be involved in chromatin remodeling. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape..
Protein Sequence	MAEPSPARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEVPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGPPPSLVEIHRGRQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTLIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGPQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFDAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMSARISGDTSSEEERFMKPKVTMIAWNQDDSTVVTAVNDHVLKVWSSYTGQLLHNLLGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGIKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENSADEHLVPQLGYVATSDGEVIEQIISLHTNDSGDASPESSVLDGMIRQLQQQQDQRLGVDQDGTANGLPSGEGTPRRGSFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVPEAPPGMFRRLEDIRIERGEEERNLYVIGRKKKTFQVPQKSNSMVLVSQSRQRTCRRKYANYSRRNADQCELSSGNESSGSVRHETSYDQSEGSCSSEDDEWRNDRRSGSDSDSSSDSSSQYSDWTADTGINLQPPLRMSCRRRVTRFCSTSEDEMSMENISPPKRRRKRRKESKPKRESLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQMGDEVMYFRQGHEAYIEAVRRNNIYELNPHKEPWRKMDLRDQELVKIVGLRYEVGPPTLCCLKLAFIDPATGRLTDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQPCDRFRSIIDDAWWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTETEKLSPWDMEPIPDNVDPPEELGASISVTSDELEKLLYKPQEGEWGQRSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVVAYPTDLYTIRMRLVNRFYRRLSALIWEVRYIEHNARTFNEPESVIARSAKKITDQLLKFIKNQDCTNISELCNTSDNDEDDSADDLDDSDLPKTSSGRRKVHNWKRRSRASGCIESDWRRQCKALLILIFQCEDSEPFRQPVDLDEYPDYRDIIDTPMDFGTVRETLEAGNYDSPVEFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISFDFKIGQKFKEKLRRSQRFKQRQNCNGAVPGDRRRRNVKQKQFKSQTKVIPQLMCPPSQSTSSKVPLSATRKTSAGVSSGFTSGDSSDSAGSLERVRRQRPEVLRSGSVLFGSEMEDFLATSSSSSASNSSEESKASPGARESSLRSGVLRGSNLGVTRTRAARRKAGSVSLENGCGRKATRKRVYLSDSDNNSVETDENLKNRKCGSSRKVLRKCAAVAASKIKLMSDAEDSSSESPCSGRKLPHRNASAVARKKLLHNSDDQSLKSETEELKDQNQSLLISGPHSVHNSISDSESDSDLRATRKTWNANGCTSHTAATCKTKSRPIESSEEDSRCHGSDHGPSSTGDPSTSGQKLRADSISEEADSEPESSVLCKNTHLCKKAKILSDSEDCEEKCGERRGPEVEGSPVSEALREAILAPQCLSHRGSETDVDSDGGAVREKSYSNENGSVSLENGQRRKVSRKSSSDKESNLQVTQKSPKDRSSPSRITQRASVATDKMKLTSDAEDLSLESVCTRSKRRRKKPARFACTPAKTALSSEEKHAHCEVPEAQPACRNKLPEPEHQDSAENPSQAASADLNSGGGSSFEQRKSIQSRQMGAVCVRPPPKTQSSSAGLSQENARSQTLDSETSLPSESVLTQKATVESNFEEELNYGLRRWNGRRLRTYGKAPLSRTAQVTPSLQASAEVGVKRRRMHPEVDGEDVPGQMGSSGCGPDTSPKASDLGSVTDSDVDCTDNTQTQRKKKRKGKARVLSKESVRKDREPHTKMRPCMLNEKDAVQMHSDTLKAKTVPEKVPRRCATVAANKIKMMCNLKEVVSGPENVGIRTISRKLPYRQASAAAKKKLLSVYKEDDAPIHSENEKELYLRRFRSRKEKAQPTPR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	FLIARYLSAGPCRRA HHHHHHHCCCHHHHH	23.42	25338131
404	Phosphorylation	FEQLEWRSILLDMSA EEHHCHHHHHHHHHH	20.75	28059163
418	Phosphorylation	ARISGDTSSEEERFM HHHCCCCCCHHHHHC	40.26	27566939
677	Phosphorylation	LGVDQDGTANGLPSG CCCCCCCCCCCCCCC	25.82	25293948
683	Phosphorylation	GTANGLPSGEGTPRR CCCCCCCCCCCCCCC	55.29	28066266
687	Phosphorylation	GLPSGEGTPRRGSFR CCCCCCCCCCCCCEE	14.87	21082442
697	Phosphorylation	RGSFRRLSLDIQSPP CCCEEEEEEECCCCC	23.37	26824392
702	Phosphorylation	RLSLDIQSPPNIGLR EEEEECCCCCCCCCC	42.53	22817900
711	Phosphorylation	PNIGLRRSGQVEGVR CCCCCCCCCCCCHHH	27.43	-
798	Phosphorylation	VSQSRQRTCRRKYAN EEHHHHHHHHHHHHC	11.30	28576409
1039	Phosphorylation	TGRLTDKSFSIRYHD CCCCCCCCEEEEECC	27.34	30387612
1041	Phosphorylation	RLTDKSFSIRYHDMP CCCCCCEEEEECCCC	17.16	21454597
1044	Phosphorylation	DKSFSIRYHDMPDVI CCCEEEEECCCCCHH	10.66	20139300
1220	Phosphorylation	MRLVNRFYRRLSALI HHHHHHHHHHHHHHH	7.50	21454597
1224	Phosphorylation	NRFYRRLSALIWEVR HHHHHHHHHHHHHHH	21.15	21454597
1239	Phosphorylation	YIEHNARTFNEPESV HHHHCCCCCCCCHHH	28.53	22802335
1291	Phosphorylation	SADDLDDSDLPKTSS CCCCCCCCCCCCCCC	40.49	-
1313	Phosphorylation	WKRRSRASGCIESDW CHHHHCCCCCCCCHH	32.84	22817900
1318	Phosphorylation	RASGCIESDWRRQCK CCCCCCCCHHHHHHC	23.67	29233185
1481	Phosphorylation	LMCPPSQSTSSKVPL HCCCCCCCCCCCCCC	34.30	-
1489	Phosphorylation	TSSKVPLSATRKTSA CCCCCCCCCCCCCCC	22.86	28066266
1491	Phosphorylation	SKVPLSATRKTSAGV CCCCCCCCCCCCCCC	29.35	28066266
1494	Phosphorylation	PLSATRKTSAGVSSG CCCCCCCCCCCCCCC	22.10	-
1513	Phosphorylation	DSSDSAGSLERVRRQ CCCCCCHHHHHHHHH	27.12	-
1590	Phosphorylation	AARRKAGSVSLENGC HHHHHCCCCCCCCCC	17.25	27566939
1607	Phosphorylation	KATRKRVYLSDSDNN CCCCCEEEECCCCCC	12.43	30635358
1609	Phosphorylation	TRKRVYLSDSDNNSV CCCEEEECCCCCCCC	19.85	22817900
1611	Phosphorylation	KRVYLSDSDNNSVET CEEEECCCCCCCCCC	38.57	22817900
1615	Phosphorylation	LSDSDNNSVETDENL ECCCCCCCCCCCHHH	27.82	30635358
1649	Phosphorylation	ASKIKLMSDAEDSSS HHHCEECCCCCCCCC	44.07	30482847
1654	Phosphorylation	LMSDAEDSSSESPCS ECCCCCCCCCCCCCC	27.54	30482847
1655	Phosphorylation	MSDAEDSSSESPCSG CCCCCCCCCCCCCCC	50.91	30482847
1656	Phosphorylation	SDAEDSSSESPCSGR CCCCCCCCCCCCCCC	46.15	28059163
1658	Phosphorylation	AEDSSSESPCSGRKL CCCCCCCCCCCCCCC	32.90	30482847
1682	Phosphorylation	RKKLLHNSDDQSLKS HHHHHCCCCCCHHHH	31.64	28973931
1686	Phosphorylation	LHNSDDQSLKSETEE HCCCCCCHHHHHHHH	44.77	28973931
1689	Phosphorylation	SDDQSLKSETEELKD CCCCHHHHHHHHHHH	55.85	22324799
1691	Phosphorylation	DQSLKSETEELKDQN CCHHHHHHHHHHHHC	41.68	26643407
1700	Phosphorylation	ELKDQNQSLLISGPH HHHHHCCCEEECCCC	32.46	26643407
1704	Phosphorylation	QNQSLLISGPHSVHN HCCCEEECCCCCCCC	46.36	26643407
1708	Phosphorylation	LLISGPHSVHNSISD EEECCCCCCCCCCCC	28.36	26643407
1712	Phosphorylation	GPHSVHNSISDSESD CCCCCCCCCCCCCCH	14.48	26643407
1714	Phosphorylation	HSVHNSISDSESDSD CCCCCCCCCCCCHHH	34.60	26643407
1716	Phosphorylation	VHNSISDSESDSDLR CCCCCCCCCCHHHHH	32.01	26643407
1718	Phosphorylation	NSISDSESDSDLRAT CCCCCCCCHHHHHHC	46.49	26643407
1720	Phosphorylation	ISDSESDSDLRATRK CCCCCCHHHHHHCHH	48.07	26643407
1725	Phosphorylation	SDSDLRATRKTWNAN CHHHHHHCHHHCCCC	26.68	26643407
1746	Phosphorylation	AATCKTKSRPIESSE CCCCCCCCCCCCCCC	48.82	28066266
1751	Phosphorylation	TKSRPIESSEEDSRC CCCCCCCCCCCCCCC	43.71	25521595
1752	Phosphorylation	KSRPIESSEEDSRCH CCCCCCCCCCCCCCC	32.01	25521595
1756	Phosphorylation	IESSEEDSRCHGSDH CCCCCCCCCCCCCCC	39.84	21659605
1761	Phosphorylation	EDSRCHGSDHGPSST CCCCCCCCCCCCCCC	11.63	25159016
1766	Phosphorylation	HGSDHGPSSTGDPST CCCCCCCCCCCCCCC	45.16	25777480
1767	Phosphorylation	GSDHGPSSTGDPSTS CCCCCCCCCCCCCCC	39.27	25777480
1768	Phosphorylation	SDHGPSSTGDPSTSG CCCCCCCCCCCCCCC	50.36	25777480
1772	Phosphorylation	PSSTGDPSTSGQKLR CCCCCCCCCCCCCCC	39.69	25777480
1773	Phosphorylation	SSTGDPSTSGQKLRA CCCCCCCCCCCCCCC	42.12	25777480
1774	Phosphorylation	STGDPSTSGQKLRAD CCCCCCCCCCCCCCC	43.49	25777480
1782	Phosphorylation	GQKLRADSISEEADS CCCCCCCCCCCCCCC	27.33	21082442
1784	Phosphorylation	KLRADSISEEADSEP CCCCCCCCCCCCCCC	33.08	21082442
1789	Phosphorylation	SISEEADSEPESSVL CCCCCCCCCCCHHCC	63.20	21082442
1793	Phosphorylation	EADSEPESSVLCKNT CCCCCCCHHCCCCCC	36.14	25619855
1794	Phosphorylation	ADSEPESSVLCKNTH CCCCCCHHCCCCCCH	19.90	25619855
1810	Phosphorylation	CKKAKILSDSEDCEE HHHCEECCCHHHHHH	42.43	25521595
1812	Phosphorylation	KAKILSDSEDCEEKC HCEECCCHHHHHHHH	31.77	25521595
1830	Phosphorylation	RGPEVEGSPVSEALR CCCCCCCCCHHHHHH	14.50	26824392
1833	Phosphorylation	EVEGSPVSEALREAI CCCCCCHHHHHHHHH	22.12	27149854
1847	Phosphorylation	ILAPQCLSHRGSETD HHCHHHHHCCCCCCC	20.82	21659605
1851	Phosphorylation	QCLSHRGSETDVDSD HHHHCCCCCCCCCCC	36.96	21082442
1853	Phosphorylation	LSHRGSETDVDSDGG HHCCCCCCCCCCCCC	42.91	21082442
1857	Phosphorylation	GSETDVDSDGGAVRE CCCCCCCCCCCCEEE	37.69	25521595
1888	Phosphorylation	RRKVSRKSSSDKESN EEECCCCCCCCHHHC	33.68	28066266
1889	Phosphorylation	RKVSRKSSSDKESNL EECCCCCCCCHHHCC	45.66	29895711
1890	Phosphorylation	KVSRKSSSDKESNLQ ECCCCCCCCHHHCCC	60.85	26824392
1894	Phosphorylation	KSSSDKESNLQVTQK CCCCCHHHCCCCCCC	48.89	23984901
1899	Phosphorylation	KESNLQVTQKSPKDR HHHCCCCCCCCCCCC	19.81	28066266
1902	Phosphorylation	NLQVTQKSPKDRSSP CCCCCCCCCCCCCCC	27.62	28066266
1907	Phosphorylation	QKSPKDRSSPSRITQ CCCCCCCCCCCHHHH	57.65	23375375
1908	Phosphorylation	KSPKDRSSPSRITQR CCCCCCCCCCHHHHH	27.99	23375375
1910	Phosphorylation	PKDRSSPSRITQRAS CCCCCCCCHHHHHHH	37.96	29895711
1917	Phosphorylation	SRITQRASVATDKMK CHHHHHHHHHCCCCC	17.93	29514104
1926	Phosphorylation	ATDKMKLTSDAEDLS HCCCCCCCCCHHHCC	21.02	21082442
1927	Phosphorylation	TDKMKLTSDAEDLSL CCCCCCCCCHHHCCH	45.30	25521595
1933	Phosphorylation	TSDAEDLSLESVCTR CCCHHHCCHHHHHHH	42.27	25619855
1939	Phosphorylation	LSLESVCTRSKRRRK CCHHHHHHHHHHHCC	35.50	15345747
1954	Phosphorylation	KPARFACTPAKTALS CCCCEECCHHHHCCC	23.89	30482847
2004	Phosphorylation	AASADLNSGGGSSFE HHHCCCCCCCCCCHH	46.22	-
2018	Phosphorylation	EQRKSIQSRQMGAVC HHHHHHCCCCCCCEE	23.86	22802335
2032	Phosphorylation	CVRPPPKTQSSSAGL EECCCCCCCCCCCCC	39.18	25777480
2034	Phosphorylation	RPPPKTQSSSAGLSQ CCCCCCCCCCCCCCH	31.34	25777480
2035	Phosphorylation	PPPKTQSSSAGLSQE CCCCCCCCCCCCCHH	17.87	25521595
2036	Phosphorylation	PPKTQSSSAGLSQEN CCCCCCCCCCCCHHH	31.44	25777480
2040	Phosphorylation	QSSSAGLSQENARSQ CCCCCCCCHHHHHHC	34.23	17525332
2046	Phosphorylation	LSQENARSQTLDSET CCHHHHHHCCCCCCC	25.71	25777480
2048	Phosphorylation	QENARSQTLDSETSL HHHHHHCCCCCCCCC	33.50	25777480
2062	Phosphorylation	LPSESVLTQKATVES CCCHHHCCCEEEECC	26.35	25777480
2140	Phosphorylation	SSGCGPDTSPKASDL CCCCCCCCCCCHHHC	50.49	25293948
2141	Phosphorylation	SGCGPDTSPKASDLG CCCCCCCCCCHHHCC	31.61	25293948
2145	Phosphorylation	PDTSPKASDLGSVTD CCCCCCHHHCCCCCC	39.22	28066266
2149	Phosphorylation	PKASDLGSVTDSDVD CCHHHCCCCCCCCCC	29.19	21149613
2151	Phosphorylation	ASDLGSVTDSDVDCT HHHCCCCCCCCCCCC	31.33	21149613
2153	Phosphorylation	DLGSVTDSDVDCTDN HCCCCCCCCCCCCCC	30.12	21149613
2158	Phosphorylation	TDSDVDCTDNTQTQR CCCCCCCCCCHHHHH	28.02	28066266
2199	Acetylation	RPCMLNEKDAVQMHS CCCCCCHHHHHHHCC	50.33	19855115

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BRWD1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BRWD1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BRWD1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of BRWD1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BRWD1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1751 AND SER-1752, ANDMASS SPECTROMETRY.	19367708 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2040, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1782; SER-1784 ANDSER-1789, AND MASS SPECTROMETRY.	17242355 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1830, AND MASSSPECTROMETRY.	16452087 [Abstract]