BRPF3_HUMAN - dbPTM
BRPF3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BRPF3_HUMAN
UniProt AC Q9ULD4
Protein Name Bromodomain and PHD finger-containing protein 3
Gene Name BRPF3
Organism Homo sapiens (Human).
Sequence Length 1205
Subcellular Localization
Protein Description Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity..
Protein Sequence MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFRMVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEEEEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIPSYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQKLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEPTGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLSDNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSPASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSGGLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLEPLELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFVTSSYL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationQNAEGRRSPSPYSLK
CCCCCCCCCCCCCCC		28.5026503892
19PhosphorylationAEGRRSPSPYSLKCS
CCCCCCCCCCCCCCC		37.4026503892
21PhosphorylationGRRSPSPYSLKCSPT
CCCCCCCCCCCCCCC		30.8522167270
22PhosphorylationRRSPSPYSLKCSPTR
CCCCCCCCCCCCCCH		25.4122167270
26PhosphorylationSPYSLKCSPTRETLT
CCCCCCCCCCHHCCC		27.9330108239
28PhosphorylationYSLKCSPTRETLTYA
CCCCCCCCHHCCCHH		25.5030108239
31PhosphorylationKCSPTRETLTYAQAQ
CCCCCHHCCCHHHHC		22.5530108239
33PhosphorylationSPTRETLTYAQAQRI
CCCHHCCCHHHHCEE		25.0027251275
55PhosphorylationRLHRISIYDPLKIIT
CEEEEEECCCCEECC		12.5228555341
67PhosphorylationIITEDELTAQDITEC
ECCCCCCCHHHHHHC		21.8928102081
72PhosphorylationELTAQDITECNSNKE
CCCHHHHHHCCCCCC		42.6528348404
76PhosphorylationQDITECNSNKENSEQ
HHHHHCCCCCCCCCC		62.0229507054
89AcetylationEQPQFPGKSKKPSSK
CCCCCCCCCCCCCCC		60.3825953088
91AcetylationPQFPGKSKKPSSKGK
CCCCCCCCCCCCCCC		72.667973261
92AcetylationQFPGKSKKPSSKGKK
CCCCCCCCCCCCCCC		58.1715606681
96AcetylationKSKKPSSKGKKKESC
CCCCCCCCCCCCCCC		78.187973269
98AcetylationKKPSSKGKKKESCSK
CCCCCCCCCCCCCCC		65.497973277
100AcetylationPSSKGKKKESCSKHA
CCCCCCCCCCCCCCC		59.3425953088
105AcetylationKKKESCSKHASGTSF
CCCCCCCCCCCCCCC		47.7421466224
262PhosphorylationLCRCCLQSPSRPVDC
EEHHHCCCCCCCEEE		16.3426699800
275AcetylationDCILCPNKGGAFKQT
EEEECCCCCCCCEEC		43.8126051181
329AcetylationKLTCYICKQKGLGAA
EEEEEEECCCCCCEE		45.5522424773
329AcetylationKLTCYICKQKGLGAA
EEEEEEECCCCCCEE		45.55-
341AcetylationGAAIQCHKVNCYTAF
CEEEEEEECCCEEEE		42.6525953088
345PhosphorylationQCHKVNCYTAFHVTC
EEEECCCEEEEEEHH		8.90-
346PhosphorylationCHKVNCYTAFHVTCA
EEECCCEEEEEEHHH		25.66-
351PhosphorylationCYTAFHVTCAQRAGL
CEEEEEEHHHHHCCE		8.11-
387PhosphorylationTAYCEAHSPPGAATA
EEEEECCCCCCHHHH		39.5828985074
400PhosphorylationTARRKGDSPRSISET
HHHHCCCCCCCCCCC		30.7725159151
403PhosphorylationRKGDSPRSISETGDE
HCCCCCCCCCCCCCC		33.5729255136
405PhosphorylationGDSPRSISETGDEEG
CCCCCCCCCCCCCCC		30.2829255136
407PhosphorylationSPRSISETGDEEGLK
CCCCCCCCCCCCCCC		43.0421406692
442AcetylationGGVSGSLKGVPKKSK
CCCCCCCCCCCCCCC		60.6126051181
447AcetylationSLKGVPKKSKMSLKQ
CCCCCCCCCCCCHHH		49.6019608861
449AcetylationKGVPKKSKMSLKQKI
CCCCCCCCCCHHHHH		41.1919608861
467PhosphorylationPEEAGQDTPSTLPML
HHHCCCCCCCCCCCC		15.9729116813
470PhosphorylationAGQDTPSTLPMLAVP
CCCCCCCCCCCCCCC		35.7629116813
481PhosphorylationLAVPQIPSYRLNKIC
CCCCCCCCHHHHHHH		25.2324719451
482PhosphorylationAVPQIPSYRLNKICS
CCCCCCCHHHHHHHH		17.4829116813
492PhosphorylationNKICSGLSFQRKNQF
HHHHHCCCHHHHHHH		23.9024719451
525PhosphorylationPLIRRLHSHLQSQRN
HHHHHHHHHHHHHHH		30.4030266825
541AcetylationEQREQDEKTSAVKEE
HHHHHHHHHHHHHHH		56.95-
541AcetylationEQREQDEKTSAVKEE
HHHHHHHHHHHHHHH		56.9523749302
546AcetylationDEKTSAVKEELKYWQ
HHHHHHHHHHHHHHH		45.23-
546AcetylationDEKTSAVKEELKYWQ
HHHHHHHHHHHHHHH		45.2323749302
550AcetylationSAVKEELKYWQKLRH
HHHHHHHHHHHHHHH		47.9626051181
554AcetylationEELKYWQKLRHDLER
HHHHHHHHHHHHHHH		33.0819608861
645PhosphorylationTMRRKLESHLYRTLE
HHHHHHHHHHHHHHH		29.2729496963
671AcetylationNCMKYNAKDTIFHRA
CHHHCCCCCCHHHHH		52.33-
671AcetylationNCMKYNAKDTIFHRA
CHHHCCCCCCHHHHH		52.3319608861
708PhosphorylationGYDPERGTHLPESPK
CCCCCCCCCCCCCCC		26.8520363803
713PhosphorylationRGTHLPESPKLEDFY
CCCCCCCCCCHHHHH		25.9523401153
720PhosphorylationSPKLEDFYRFSWEDV
CCCHHHHHCCCHHHH		24.0720873877
740PhosphorylationPENRAHLSPEVQLKE
CCCCCCCCHHHHHHH		14.7830266825
756PhosphorylationLEKLDLVSAMRSSGA
HHHHHHHHHHHCCCH		24.52-
792PhosphorylationPPPPQPPSLNKTVSN
CCCCCCCCCCCCCCC		51.7825159151
852PhosphorylationPSLSEQESPPEPPTL
CCCCCCCCCCCCCCC		45.5125159151
886PhosphorylationEDELLEKSPLQLGNE
HHHHHHHCCCCCCCH		22.8221815630
900PhosphorylationEPLQRLLSDNGINRL
HHHHHHHHCCCCCCE		33.3530266825
908PhosphorylationDNGINRLSLMAPDTP
CCCCCCEEEECCCCC		16.9224667141
914PhosphorylationLSLMAPDTPAGTPLS
EEEECCCCCCCCCCC		17.6122199227
918PhosphorylationAPDTPAGTPLSGVGR
CCCCCCCCCCCCCCH		24.1422199227
921PhosphorylationTPAGTPLSGVGRRTS
CCCCCCCCCCCHHHH		32.4122199227
927PhosphorylationLSGVGRRTSVLFKKA
CCCCCHHHHHHHHHC		23.0923312004
928PhosphorylationSGVGRRTSVLFKKAK
CCCCHHHHHHHHHCC		18.2722817900
943PhosphorylationNGVKLQRSPDRVLEN
CCCCCCCCCCHHHCC		20.4225849741
959PhosphorylationEDHGVAGSPASPASI
CCCCCCCCCCCCCHH		13.9326503892
962PhosphorylationGVAGSPASPASIEEE
CCCCCCCCCCHHHHH		25.1226503892
965PhosphorylationGSPASPASIEEERHS
CCCCCCCHHHHHHHC		33.6426503892
972PhosphorylationSIEEERHSRKRPRSR
HHHHHHHCCCCCCCC		45.8021406692
982PhosphorylationRPRSRSCSESEGERS
CCCCCCCCCCCCCCC		45.46-
989PhosphorylationSESEGERSPQQEEET
CCCCCCCCHHHHHHH		23.8218452278
1036PhosphorylationGLTPPKRSRGKPALS
CCCCCCCCCCCCCHH		52.0624505115
1039AcetylationPPKRSRGKPALSRVP
CCCCCCCCCCHHCCC		26.4623749302
1043PhosphorylationSRGKPALSRVPFLEG
CCCCCCHHCCCCCCC		33.0824505115
1142AcetylationLVLFFDNKRTWQWLP
EEEEECCCCCEEECC		53.7222361679
1191PhosphorylationDRAMIHLSRVRGPHS
HHHHHHHHHCCCCCC		17.99-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BRPF3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BRPF3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BRPF3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of BRPF3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BRPF3_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-105; LYS-447; LYS-449;LYS-546; LYS-554 AND LYS-671, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-962 AND SER-965, ANDMASS SPECTROMETRY.
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-720, AND MASSSPECTROMETRY.

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