BRDT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BRDT_HUMAN
• UniProt AC: Q58F21
• Protein Name: Bromodomain testis-specific protein
• Gene Name: BRDT
• Organism: Homo sapiens (Human).
• Sequence Length: 947
• Subcellular Localization: Nucleus . Detected on chromatin.
• Protein Description: Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. [PubMed: 22464331]
• Protein Sequence: MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSVFPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSVALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRLKEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECIPPEGRTGVTQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGDSDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKARTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQDKSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MSLPSRQTAIIV ---CCCCCCCEEEEE	42.17	30257219
8	Phosphorylation	MSLPSRQTAIIVNPP CCCCCCCEEEEECCC	20.79	27067055
19	Phosphorylation	VNPPPPEYINTKKNG ECCCCHHHCCCCCCC	12.78	27067055
22	Phosphorylation	PPPEYINTKKNGRLT CCHHHCCCCCCCCCC	33.56	27067055
66	Phosphorylation	VKLQLPDYYTIIKNP EECCCCCCCHHHCCC	10.68	22210691
163	Phosphorylation	VSSAKEKSSPSATEK CCCCCCCCCCHHHHH	48.88	22210691
166	Phosphorylation	AKEKSSPSATEKVFK CCCCCCCHHHHHHHH	50.17	22210691
168	Phosphorylation	EKSSPSATEKVFKQQ CCCCCHHHHHHHHHC	40.45	22210691
187	Phosphorylation	VFPKTSISPLNVVQG CCCCCCCCCCCCCCC	24.09	-
196	Phosphorylation	LNVVQGASVNSSSQT CCCCCCCCCCCCHHH	28.76	18077418
199	Phosphorylation	VQGASVNSSSQTAAQ CCCCCCCCCHHHHHH	29.25	18077418
201	Phosphorylation	GASVNSSSQTAAQVT CCCCCCCHHHHHHHH	31.22	18077418
263	Ubiquitination	DSQQQYNVVKTVKVT CHHHHHCEEHHHHHH	3.88	22505724
270	Phosphorylation	VVKTVKVTEQLRHCS EEHHHHHHHHHHHHH	16.58	30377224
277	Phosphorylation	TEQLRHCSEILKEML HHHHHHHHHHHHHHH	22.88	28355574
281	Phosphorylation	RHCSEILKEMLAKKH HHHHHHHHHHHHHCC	46.90	27251275
290	Ubiquitination	MLAKKHFSYAWPFYN HHHHCCCCCCCCCCC	17.41	22505724
291	Phosphorylation	LAKKHFSYAWPFYNP HHHCCCCCCCCCCCC	16.25	18083107
296	Phosphorylation	FSYAWPFYNPVDVNA CCCCCCCCCCCCCCC	17.93	18083107
309	Phosphorylation	NALGLHNYYDVVKNP CCCCCCCHHHHHCCC	7.12	18083107
310	Phosphorylation	ALGLHNYYDVVKNPM CCCCCCHHHHHCCCC	13.95	18083107
331	Phosphorylation	EKMDNQEYKDAYKFA HHCCCHHHHHHHHHH	12.38	-
335	Phosphorylation	NQEYKDAYKFAADVR CHHHHHHHHHHHHHH	19.44	-
336	Ubiquitination	QEYKDAYKFAADVRL HHHHHHHHHHHHHHH	30.19	22505724
340	Ubiquitination	DAYKFAADVRLMFMN HHHHHHHHHHHHHHH	23.73	22505724
349 (in isoform 2)	Ubiquitination	-	16.11	-
383	Phosphorylation	IPIEPVESMPLCYIK CCCCCCCCCCEEEEE	26.40	22167270
388	Phosphorylation	VESMPLCYIKTDITE CCCCCEEEEEECCCC	17.09	22167270
402	Phosphorylation	ETTGRENTNEASSEG CCCCCCCCCCCCCCC	29.68	-
483	Acetylation	EQMRLKEKSKRNQPK HHHHHHHHHHHCCCC	60.74	88617
545	Phosphorylation	QSREPSLSNSNPDEI ECCCCCCCCCCCCCE	42.42	19276368
547	Phosphorylation	REPSLSNSNPDEIEI CCCCCCCCCCCCEEE	46.49	19276368
558	Phosphorylation	EIEIDFETLKASTLR CEEECHHHHCHHHHH	33.29	19276368
562	Phosphorylation	DFETLKASTLRELEK CHHHHCHHHHHHHHH	26.79	25404012
563	Phosphorylation	FETLKASTLRELEKY HHHHCHHHHHHHHHH	34.39	28555341
572	Phosphorylation	RELEKYVSACLRKRP HHHHHHHHHHHHCCC	15.35	-
625	Phosphorylation	RQTKSDKTQPSKAVE CCCCCCCCCHHHHHH	51.18	22210691
628	Phosphorylation	KSDKTQPSKAVENVS CCCCCCHHHHHHHHH	24.35	22210691
635	Phosphorylation	SKAVENVSRLSESSS HHHHHHHHHHCCCCC	38.80	22210691
638	Phosphorylation	VENVSRLSESSSSSS HHHHHHHCCCCCCCC	34.03	-
640	Phosphorylation	NVSRLSESSSSSSSS HHHHHCCCCCCCCCC	31.95	-
642	Phosphorylation	SRLSESSSSSSSSSE HHHCCCCCCCCCCCC	43.44	-
643	Phosphorylation	RLSESSSSSSSSSES HHCCCCCCCCCCCCC	35.87	-
644	Phosphorylation	LSESSSSSSSSSESE HCCCCCCCCCCCCCC	35.87	-
645	Phosphorylation	SESSSSSSSSSESES CCCCCCCCCCCCCCC	35.87	-
674	Phosphorylation	SEMFPKFTEVKPNDS HHCCCCCCCCCCCCC	46.09	25159151
820	Acetylation	VKPSGVMKSSDELFN CCCCCCCCCHHHHHH	44.39	19823513
821	Phosphorylation	KPSGVMKSSDELFNQ CCCCCCCCHHHHHHH	25.56	26846344
822	Phosphorylation	PSGVMKSSDELFNQF CCCCCCCHHHHHHHH	29.59	26846344
855	Acetylation	KHLEQNTKELKASQE HHHHHHHHHHHHHHH	69.47	7661825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BRDT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BRDT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BRDT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCNT1_HUMAN	CCNT1	physical	17690245
CDK9_HUMAN	CDK9	physical	17690245

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.