dbPTM

BRD3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BRD3_MOUSE
UniProt AC	Q8K2F0
Protein Name	Bromodomain-containing protein 3
Gene Name	Brd3
Organism	Mus musculus (Mouse).
Sequence Length	726
Subcellular Localization	Nucleus . Detected on chromatin.
Protein Description	Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. [PubMed: 21536911 Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets]
Protein Sequence	MSTTAAAPTGIPAVPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQNAGSQQVAAVSSVSPATPFQNIPPTVSQTPVIAATPVPTITANVTSVPVPPPAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSEPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRHCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDSREYPDAQGFAADIRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPMEAPALPAPTAPIVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKDKDKEKEKHKAKSEEEKKAKAAPAAKQAQQKKAPTKKANSTTTASRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPLSTSGKKQAAKSKEELAQEKKKELEKRLQDVSGQLNSKKPTKKEKSGSAPSGGPSRLSSSSSSESASSSSSGSSSDSSDSE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	PSKPGRKTNQLQYMQ CCCCCCCCCHHHHHH	27.17	20531401
118	Phosphorylation	CYIYNKPTDDIVLMA CEECCCCCCHHHHHH	48.16	-
247	Phosphorylation	GVKRKADTTTPTTSA CCCCCCCCCCCCCHH	37.11	28066266
248	Phosphorylation	VKRKADTTTPTTSAI CCCCCCCCCCCCHHH	31.18	26239621
249	Phosphorylation	KRKADTTTPTTSAIT CCCCCCCCCCCHHHC	22.26	26643407
251	Phosphorylation	KADTTTPTTSAITAS CCCCCCCCCHHHCCC	31.15	24453211
252	Phosphorylation	ADTTTPTTSAITASR CCCCCCCCHHHCCCC	19.84	26643407
253	Phosphorylation	DTTTPTTSAITASRS CCCCCCCHHHCCCCC	21.83	27087446
256	Phosphorylation	TPTTSAITASRSESP CCCCHHHCCCCCCCC	20.49	26643407
258	Phosphorylation	TTSAITASRSESPPP CCHHHCCCCCCCCCC	27.91	26643407
260	Phosphorylation	SAITASRSESPPPLS HHHCCCCCCCCCCCC	39.67	27087446
262	Phosphorylation	ITASRSESPPPLSEP HCCCCCCCCCCCCCC	43.91	27087446
267	Phosphorylation	SESPPPLSEPKQAKV CCCCCCCCCCCCCEE	58.59	25619855
280	Phosphorylation	KVVARRESGGRPIKP EEEEEHHHCCCCCCC	44.74	21183079
303	Acetylation	EVPQHAGKKGKLSEH CCCCCCCCCCCHHHH	60.17	130625
304	Acetylation	VPQHAGKKGKLSEHL CCCCCCCCCCHHHHH	61.43	7428769
306	Acetylation	QHAGKKGKLSEHLRH CCCCCCCCHHHHHHH	58.69	23806337
548	Phosphorylation	ANSTTTASRQLKKGG CCCCHHHHHHHHHCC	20.61	-
559	Phosphorylation	KKGGKQASASYDSEE HHCCCCCCCCCCCHH	18.43	25521595
561	Phosphorylation	GGKQASASYDSEEEE CCCCCCCCCCCHHHH	27.29	25521595
562	Phosphorylation	GKQASASYDSEEEEE CCCCCCCCCCHHHHC	24.17	25521595
564	Phosphorylation	QASASYDSEEEEEGL CCCCCCCCHHHHCCC	38.38	25521595
582	Phosphorylation	YDEKRQLSLDINRLP HHHHHCCEEEHHCCC	18.69	28059163
657	Phosphorylation	GKKQAAKSKEELAQE HHHHHHHCHHHHHHH	40.34	30387612
677	Phosphorylation	EKRLQDVSGQLNSKK HHHHHHHHHHHCCCC	29.16	-
691	Phosphorylation	KPTKKEKSGSAPSGG CCCCCCCCCCCCCCC	38.79	-
696	Phosphorylation	EKSGSAPSGGPSRLS CCCCCCCCCCCCCCC	56.98	-
703	Phosphorylation	SGGPSRLSSSSSSES CCCCCCCCCCCCCCC	27.36	29895711
704	Phosphorylation	GGPSRLSSSSSSESA CCCCCCCCCCCCCCC	38.54	29895711
705	Phosphorylation	GPSRLSSSSSSESAS CCCCCCCCCCCCCCC	30.75	29895711
706	Phosphorylation	PSRLSSSSSSESASS CCCCCCCCCCCCCCC	39.57	29895711
707	Phosphorylation	SRLSSSSSSESASSS CCCCCCCCCCCCCCC	39.82	29895711
708	Phosphorylation	RLSSSSSSESASSSS CCCCCCCCCCCCCCC	37.20	29895711
710	Phosphorylation	SSSSSSESASSSSSG CCCCCCCCCCCCCCC	35.08	29895711
712	Phosphorylation	SSSSESASSSSSGSS CCCCCCCCCCCCCCC	39.78	29895711
713	Phosphorylation	SSSESASSSSSGSSS CCCCCCCCCCCCCCC	33.68	29895711
714	Phosphorylation	SSESASSSSSGSSSD CCCCCCCCCCCCCCC	26.48	29895711
715	Phosphorylation	SESASSSSSGSSSDS CCCCCCCCCCCCCCC	40.44	29895711
716	Phosphorylation	ESASSSSSGSSSDSS CCCCCCCCCCCCCCC	44.64	29895711
718	Phosphorylation	ASSSSSGSSSDSSDS CCCCCCCCCCCCCCC	28.72	29895711
719	Phosphorylation	SSSSSGSSSDSSDSE CCCCCCCCCCCCCCC	41.51	29895711
720	Phosphorylation	SSSSGSSSDSSDSE- CCCCCCCCCCCCCC-	43.12	29895711

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BRD3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BRD3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BRD3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of BRD3_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BRD3_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-262, AND MASSSPECTROMETRY.	19131326 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-262, AND MASSSPECTROMETRY.	17242355 [Abstract]