BORG1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BORG1_MOUSE
• UniProt AC: Q8JZX9
• Protein Name: Cdc42 effector protein 2
• Gene Name: Cdc42ep2
• Organism: Mus musculus (Mouse).
• Sequence Length: 214
• Subcellular Localization: Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.
• Protein Description: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity)..
• Protein Sequence: MSTKVPIYLKRGSRKGKKEKLRDLLSSDMISPPLGDFRHTIHIGSGGGDDMFGDISFLQGKFHLLPGTAVEEAEEDGSFDLPFQFTRTTTVCGRELPDGLSPLLKNAISLPVIGGPQALTLPTAQAPPKPPRLHLESPQPSPQPSPQGAGNVDVWRIPEAGSPHNGMSPEPEAEEPFLSHASSLLSLHVDLGPSILDDVLQIMDHDLGRVQIPT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTKVPIYL ------CCCCCCEEE	36.61	29176673
2	Acetylation	------MSTKVPIYL ------CCCCCCEEE	36.61	-
3	Phosphorylation	-----MSTKVPIYLK -----CCCCCCEEEC	34.46	29176673
8	Phosphorylation	MSTKVPIYLKRGSRK CCCCCCEEECCCCCC	10.49	29514104
13	Phosphorylation	PIYLKRGSRKGKKEK CEEECCCCCCCCHHH	34.55	29514104
26	Phosphorylation	EKLRDLLSSDMISPP HHHHHHHCCCCCCCC	31.43	29514104
31	Phosphorylation	LLSSDMISPPLGDFR HHCCCCCCCCCCCCC	17.52	29514104
78	Phosphorylation	EEAEEDGSFDLPFQF CCCCCCCCCCCCEEE	28.10	26824392
90	Phosphorylation	FQFTRTTTVCGRELP EEEEEEEEECCCCCC	17.12	29514104
101	Phosphorylation	RELPDGLSPLLKNAI CCCCCCCCHHHHHCC	21.02	27180971
109	Phosphorylation	PLLKNAISLPVIGGP HHHHHCCCCCCCCCC	24.98	25521595
120	Phosphorylation	IGGPQALTLPTAQAP CCCCCCEECCCCCCC	33.44	25777480
123	Phosphorylation	PQALTLPTAQAPPKP CCCEECCCCCCCCCC	34.22	25777480
137	Phosphorylation	PPRLHLESPQPSPQP CCCCCCCCCCCCCCC	34.88	27087446
141	Phosphorylation	HLESPQPSPQPSPQG CCCCCCCCCCCCCCC	30.81	27087446
145	Phosphorylation	PQPSPQPSPQGAGNV CCCCCCCCCCCCCCE	25.30	27087446
182	Phosphorylation	EPFLSHASSLLSLHV CCHHHHHHHHHHHCC	18.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
101	S	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BORG1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BORG1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BORG1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137; SER-141 ANDSER-145, AND MASS SPECTROMETRY.
PubMed: 19144319