BNC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BNC1_MOUSE
• UniProt AC: O35914
• Protein Name: Zinc finger protein basonuclin-1
• Gene Name: Bnc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 961
• Subcellular Localization: Nucleus . Cytoplasm . Nucleus, nucleoplasm . Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids.
• Protein Description: Transcriptional activator. [PubMed: 9687312]
• Protein Sequence: MAEAIGCTLNCSCQCFKPGKINHRQCEQCRHGWVAHALSKLRIPPVYPTSQVEIVQSNVVFDISSLMLYGTQAIPVRLKILLDRLFSVLKQDEVLQILHALDWTLQDYIRGYVLQDASGKVLDHWSIMTSEEEVATLQQFLRFGETKSIVELMAIQEKEEQSVIVPPTTANVDIRAFIESCGHRSASLPTPVDKGSPGGMHPFENLISNMTFMLPFQFFNPLPPALIGSLPEQYMLEQGQDQSQEPKQELHGPFSDSSFLTSTPFQVEKEQCLNCPETVPQKEDSAHLSDSSSYSIASKLERTQLSPEAKVKPERNSLSAKKGRVFCTACEKTFYDKGTLKIHYNAVHLKIKHKCTIEGCNMVFSSLRSRNRHSANPNPRLHMPMNRNNRDKDLRNSLNLASSETYKRPGFTVVSPDCGPLPGYTGSVEDSKGQPAFSSIGQNGVLFPNLKTVQPVLPFYRSPATPAELANTPGMLPSLPLLSSSIPEQLVSTDMPFDALPKKKSRKSSMPIKIEKEAVEIAEEKRHSLSSDDEVPLQVVSEDEPEDSSPRSDRVPEEQHTQLSLEEPLPQGERACHLESVIESHGALSRTLEQTTLTEREAEQKVALSSVMPREVEDGGHERHFTAGLVPQIPFPDYMELQQRLLAGGLFGALSNRGMAFPFLEESKELEHLGEHALVRQKEEARFQCDICKKTFKNACSMKTHEKNTHARETHACTVEGCGAAFPSRRSRDRHSSNLSLHQKVLNEEALETSEDHFRAAYLLQDVAKEAYQDVAFTPQASQTSVIFKGTSGMGSLVYPISQVHSASLESYNSGPPSEGTILDLSTTSSMKSESSSHSSWDSDGVSEEGTALMEDSDGNCEGQSLVSGEDEYPLCVLMEKADQSLASLPSGLPITCHLCQKIYSNKGTFRAHYKTVHLRQLHKCKVPGCNTMFSSVRSRNRHSQNPNLHKSLASSPSHLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
190	Phosphorylation	HRSASLPTPVDKGSP CCCCCCCCCCCCCCC	41.03	29514104
306	Phosphorylation	KLERTQLSPEAKVKP HHHHHCCCCCCCCCC	15.75	22817900
415	Phosphorylation	RPGFTVVSPDCGPLP CCCEEEECCCCCCCC	15.64	25338131
505	Phosphorylation	DALPKKKSRKSSMPI CCCCCCCCCCCCCCC	54.54	-
509	Phosphorylation	KKKSRKSSMPIKIEK CCCCCCCCCCCEEEH	31.45	25338131
528	Phosphorylation	IAEEKRHSLSSDDEV HHHHHCCCCCCCCCC	33.70	25293948
530	Phosphorylation	EEKRHSLSSDDEVPL HHHCCCCCCCCCCCE	34.43	25293948
531	Phosphorylation	EKRHSLSSDDEVPLQ HHCCCCCCCCCCCEE	55.14	25293948
541	Phosphorylation	EVPLQVVSEDEPEDS CCCEEEECCCCCCCC	40.24	25293948
548	Phosphorylation	SEDEPEDSSPRSDRV CCCCCCCCCCCCCCC	40.35	25293948
549	Phosphorylation	EDEPEDSSPRSDRVP CCCCCCCCCCCCCCC	36.33	25293948
736	Phosphorylation	RRSRDRHSSNLSLHQ HHCCCCCCCCCCHHH	23.09	25338131
737	Phosphorylation	RSRDRHSSNLSLHQK HCCCCCCCCCCHHHH	35.35	25338131
754	Phosphorylation	NEEALETSEDHFRAA CHHHHHCCHHHHHHH	31.48	29514104
952	Phosphorylation	QNPNLHKSLASSPSH CCCCHHHHHCCCCCC	20.58	29514104
955	Phosphorylation	NLHKSLASSPSHLQ- CHHHHHCCCCCCCC-	48.34	25777480
956	Phosphorylation	LHKSLASSPSHLQ-- HHHHHCCCCCCCC--	25.47	29514104
958	Phosphorylation	KSLASSPSHLQ---- HHHCCCCCCCC----	38.48	25777480

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BNC1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
505	S	Phosphorylation	Phosphorylation on Ser-505 and Ser-509 leads to cytoplasmic localization.	-
509	S	Phosphorylation	Phosphorylation on Ser-505 and Ser-509 leads to cytoplasmic localization.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BNC1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BNC1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.