dbPTM

BNC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BNC1_HUMAN
UniProt AC	Q01954
Protein Name	Zinc finger protein basonuclin-1
Gene Name	BNC1
Organism	Homo sapiens (Human).
Sequence Length	994
Subcellular Localization	Nucleus . Cytoplasm . Nucleus, nucleoplasm . Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids.
Protein Description	Transcriptional activator (By similarity). Likely specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. [PubMed: 8034748 Required for the maintenance of spermatogenesis (By similarity May also play a role in the differentiation of oocytes and the early development of embryos (By similarity]
Protein Sequence	MRRRPPSRGGRGAARARETRRQPRHRSGRRMAEAISCTLNCSCQSFKPGKINHRQCDQCKHGWVAHALSKLRIPPMYPTSQVEIVQSNVVFDISSLMLYGTQAIPVRLKILLDRLFSVLKQDEVLQILHALDWTLQDYIRGYVLQDASGKVLDHWSIMTSEEEVATLQQFLRFGETKSIVELMAIQEKEEQSIIIPPSTANVDIRAFIESCSHRSSSLPTPVDKGNPSSIHPFENLISNMTFMLPFQFFNPLPPALIGSLPEQYMLEQGHDQSQDPKQEVHGPFPDSSFLTSSSTPFQVEKDQCLNCPDAITKKEDSTHLSDSSSYNIVTKFERTQLSPEAKVKPERNSLGTKKGRVFCTACEKTFYDKGTLKIHYNAVHLKIKHKCTIEGCNMVFSSLRSRNRHSANPNPRLHMPMNRNNRDKDLRNSLNLASSENYKCPGFTVTSPDCRPPPSYPGSGEDSKGQPAFPNIGQNGVLFPNLKTVQPVLPFYRSPATPAEVANTPGILPSLPLLSSSIPEQLISNEMPFDALPKKKSRKSSMPIKIEKEAVEIANEKRHNLSSDEDMPLQVVSEDEQEACSPQSHRVSEEQHVQSGGLGKPFPEGERPCHRESVIESSGAISQTPEQATHNSERETEQTPALIMVPREVEDGGHEHYFTPGMEPQVPFSDYMELQQRLLAGGLFSALSNRGMAFPCLEDSKELEHVGQHALARQIEENRFQCDICKKTFKNACSVKIHHKNMHVKEMHTCTVEGCNATFPSRRSRDRHSSNLNLHQKALSQEALESSEDHFRAAYLLKDVAKEAYQDVAFTQQASQTSVIFKGTSRMGSLVYPITQVHSASLESYNSGPLSEGTILDLSTTSSMKSESSSHSSWDSDGVSEEGTVLMEDSDGNCEGSSLVPGEDEYPICVLMEKADQSLASLPSGLPITCHLCQKTYSNKGTFRAHYKTVHLRQLHKCKVPGCNTMFSSVRSRNRHSQNPNLHKSLASSPSHLQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MRRRPPSRGGRGAA -CCCCCCCCCCCHHH	46.36	29083192
335	Phosphorylation	IVTKFERTQLSPEAK EEECEEECCCCCCCC	27.02	28176443
338	Phosphorylation	KFERTQLSPEAKVKP CEEECCCCCCCCCCC	15.75	29743597
398	Phosphorylation	GCNMVFSSLRSRNRH CCHHHHHHHHHCCCC	19.14	24719451
536	Acetylation	FDALPKKKSRKSSMP CCCCCCCCCCCCCCC	62.71	30587125
537	Phosphorylation	DALPKKKSRKSSMPI CCCCCCCCCCCCCCE	54.54	22817900
541	Phosphorylation	KKKSRKSSMPIKIEK CCCCCCCCCCEEEEH	31.45	22817900
545	Acetylation	RKSSMPIKIEKEAVE CCCCCCEEEEHHHHH	38.65	30587131
562	Phosphorylation	NEKRHNLSSDEDMPL HHHCCCCCCCCCCCE	40.85	-
563	Phosphorylation	EKRHNLSSDEDMPLQ HHCCCCCCCCCCCEE	48.46	-
573	Phosphorylation	DMPLQVVSEDEQEAC CCCEEEECHHHHHHC	40.24	-
581	Phosphorylation	EDEQEACSPQSHRVS HHHHHHCCCCCCCCC	32.78	-
613	Phosphorylation	ERPCHRESVIESSGA CCCCCHHHHHHCCCC	28.49	23927012
617	Phosphorylation	HRESVIESSGAISQT CHHHHHHCCCCCCCC	23.97	22468782
618	Phosphorylation	RESVIESSGAISQTP HHHHHHCCCCCCCCH	21.32	23927012
622	Phosphorylation	IESSGAISQTPEQAT HHCCCCCCCCHHHCC	27.71	22468782
624	Phosphorylation	SSGAISQTPEQATHN CCCCCCCCHHHCCCC	23.23	22468782
780	Phosphorylation	NLHQKALSQEALESS CHHHHHHHHHHHHCC	30.73	24719451
938	Phosphorylation	HLCQKTYSNKGTFRA EECCCCCCCCCEEEE	36.98	-
942	Phosphorylation	KTYSNKGTFRAHYKT CCCCCCCEEEEEEEE	16.14	-
965	Phosphorylation	CKVPGCNTMFSSVRS CCCCCCHHCCHHHHC	24.54	-
985	Phosphorylation	QNPNLHKSLASSPSH CCCCHHHHHCCCCCC	20.58	23927012
988	Phosphorylation	NLHKSLASSPSHLQ- CHHHHHCCCCCCCC-	48.34	23927012
989	Phosphorylation	LHKSLASSPSHLQ-- HHHHHCCCCCCCC--	25.47	25394399
991	Phosphorylation	KSLASSPSHLQ---- HHHCCCCCCCC----	38.48	23927012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
541	S	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
537	S	Phosphorylation	9223293
Phosphorylation on Ser-537 and Ser-541 leads to cytoplasmic localization.
541	S	Phosphorylation	9223293
Phosphorylation on Ser-537 and Ser-541 leads to cytoplasmic localization.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BNC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of BNC1_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BNC1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Nuclear localization of basonuclin in human keratinocytes and therole of phosphorylation."; Iuchi S., Green H.; Proc. Natl. Acad. Sci. U.S.A. 94:7948-7953(1997). Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL, PHOSPHORYLATION ATSER-537 AND SER-541, AND MUTAGENESIS OF SER-537; SER-540 AND SER-541.	9223293 [Abstract]

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