BMR1A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BMR1A_RAT
• UniProt AC: Q78EA7
• Protein Name: Bone morphogenetic protein receptor type-1A
• Gene Name: Bmpr1a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 532
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6..
• Protein Sequence: MTQLYTYIRLLGACLFIISHVQGQNLDSMLHGTGMKSDVDQKKPENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLTSGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSVRWLAVLISMAVCIVAMIVFSSCFCYKHYCKSISSRGRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDIPLNTRVGTRRYMAPEVLDESLSKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
73	N-linked_Glycosylation	HCPDDAINNTCITNG CCCCCHHCCCEEECC	39.21	-
205	Phosphorylation	AFIPVGESLKDLIDQ CCEECCHHHHHHHHH	34.49	22673903
213	Phosphorylation	LKDLIDQSQSSGSGS HHHHHHHHHCCCCCC	28.43	27097102
215	Phosphorylation	DLIDQSQSSGSGSGL HHHHHHHCCCCCCCH	41.74	27097102
216	Phosphorylation	LIDQSQSSGSGSGLP HHHHHHCCCCCCCHH	29.37	27097102
218	Phosphorylation	DQSQSSGSGSGLPLL HHHHCCCCCCCHHHH	31.56	27097102
220	Phosphorylation	SQSSGSGSGLPLLVQ HHCCCCCCCHHHHHH	38.56	27097102
523	Ubiquitination	RIKKTLAKMVESQDV HHHHHHHHHHHCCCC	46.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BMR1A_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BMR1A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BMR1A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of BMR1A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.