BMPR2_MOUSE - dbPTM
BMPR2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BMPR2_MOUSE
UniProt AC O35607
Protein Name Bone morphogenetic protein receptor type-2
Gene Name Bmpr2
Organism Mus musculus (Mouse).
Sequence Length 1038
Subcellular Localization Cell membrane
Single-pass type I membrane protein.
Protein Description On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. [PubMed: 23527555]
Protein Sequence MTSSLHRPFRVPWLLWAVLLVSTTAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHSMNMMEAAAAEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERLTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGACVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEVFMRCTDLFPGESVPDYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETHLHATNVAQSIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEVTGQQDFTQAANGQACLIPDVPPAQIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGNKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRSHNVNSHAATTQYANGAVPAGQAANIVAHRSQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDILTQGVTSTAADPGPSKPRRAQRPNSLDLSATNILDGSSIQIGESTQDGKSGSGEKIKRRVKTPYSLKRWRPSTWVISTEPLDCEVNNNGSDRAVHSKSSTAVYLAEGGTATTTVSKDIGMNCL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
55N-linked_GlycosylationESRISHENGTILCSK
CCEEECCCCEEEECC		47.70-
110N-linked_GlycosylationTTPPSIQNGTYRFCC
CCCCCCCCCCEEEEE		43.00-
126N-linked_GlycosylationSTDLCNVNFTENFPP
CCCCCCCCCCCCCCC		24.91-
128PhosphorylationDLCNVNFTENFPPPD
CCCCCCCCCCCCCCC		25.47-
180UbiquitinationRMLTGDRKQGLHSMN
HHHHCCCCCCHHHCC		54.1522790023
185PhosphorylationDRKQGLHSMNMMEAA
CCCCCHHHCCHHHHH		19.5225338131
375PhosphorylationEEDNAAISEVGTIRY
CCCCCHHCCCCCCEE		22.8528066266
379PhosphorylationAAISEVGTIRYMAPE
CHHCCCCCCEECCHH		13.8828066266
512UbiquitinationMMIWERNKSVSPTVN
HHHHHCCCCCCCCCC		59.4622790023
513PhosphorylationMIWERNKSVSPTVNP
HHHHCCCCCCCCCCH		31.2325521595
515PhosphorylationWERNKSVSPTVNPMS
HHCCCCCCCCCCHHH		23.1925521595
517PhosphorylationRNKSVSPTVNPMSTA
CCCCCCCCCCHHHHH		25.9621454597
546PhosphorylationKIGPYPDYSSSSYIE
CCCCCCCCCCCCHHH		13.1229514104
548PhosphorylationGPYPDYSSSSYIEDS
CCCCCCCCCCHHHHH		19.64-
551PhosphorylationPDYSSSSYIEDSIHH
CCCCCCCHHHHHHCC		15.4129899451
555PhosphorylationSSSYIEDSIHHTDSI
CCCHHHHHHCCCHHH		15.8421082442
561PhosphorylationDSIHHTDSIVKNISS
HHHCCCHHHHHHCCC		30.3622817900
571PhosphorylationKNISSEHSMSSTPLT
HHCCCCCCCCCCCEE		19.1329514104
575PhosphorylationSEHSMSSTPLTIGEK
CCCCCCCCCEECCCC		18.27-
586PhosphorylationIGEKNRNSINYERQQ
CCCCCCCCCCHHHHH		14.6926824392
589PhosphorylationKNRNSINYERQQAQA
CCCCCCCHHHHHHHH		15.7229514104
680PhosphorylationVDKNLKESSDENLME
HHHHHHHCCCHHHHH		41.3125521595
681PhosphorylationDKNLKESSDENLMEH
HHHHHHCCCHHHHHH		50.4625521595
689PhosphorylationDENLMEHSLKQFSGP
CHHHHHHHHHHHCCC		24.7729899451
694PhosphorylationEHSLKQFSGPDPLSS
HHHHHHHCCCCCCCC		47.0929899451
700PhosphorylationFSGPDPLSSTSSSLL
HCCCCCCCCCCHHHH		36.6425367039
701PhosphorylationSGPDPLSSTSSSLLY
CCCCCCCCCCHHHHH		39.7425367039
702PhosphorylationGPDPLSSTSSSLLYP
CCCCCCCCCHHHHHH		29.2925367039
703PhosphorylationPDPLSSTSSSLLYPL
CCCCCCCCHHHHHHH		21.6325367039
704PhosphorylationDPLSSTSSSLLYPLI
CCCCCCCHHHHHHHH		25.7025367039
705PhosphorylationPLSSTSSSLLYPLIK
CCCCCCHHHHHHHHH		23.3525367039
708PhosphorylationSTSSSLLYPLIKLAV
CCCHHHHHHHHHHHH		10.9825367039
756PhosphorylationQNLPKRPTSLPLNTK
CCCCCCCCCCCCCCC		47.1029514104
757PhosphorylationNLPKRPTSLPLNTKN
CCCCCCCCCCCCCCC		30.5826824392
782UbiquitinationNKHKSNLKQVETGVA
HHHHHHHHHHHHHHH		57.4522790023
825PhosphorylationSHAATTQYANGAVPA
CCCCHHHHCCCCCCH		10.4329514104
843PhosphorylationANIVAHRSQEMLQNQ
HHHHHHHCHHHHHCC		22.1827742792
856PhosphorylationNQFIGEDTRLNINSS
CCCCCCCCCCCCCCC		32.5229899451
862PhosphorylationDTRLNINSSPDEHEP
CCCCCCCCCCCCCCH		39.1826824392
863PhosphorylationTRLNINSSPDEHEPL
CCCCCCCCCCCCCHH		31.7025521595
900PhosphorylationRPLEGGRTNSNNNNS
CCCCCCCCCCCCCCC		46.39-
902PhosphorylationLEGGRTNSNNNNSNP
CCCCCCCCCCCCCCC		40.08-
907PhosphorylationTNSNNNNSNPCSEQD
CCCCCCCCCCCCHHH		44.25-
911PhosphorylationNNNSNPCSEQDILTQ
CCCCCCCCHHHHHHC		39.28-
940PhosphorylationRRAQRPNSLDLSATN
CCCCCCCCCCCCCCE		26.4127087446
944PhosphorylationRPNSLDLSATNILDG
CCCCCCCCCCEECCC		32.4929899451
977PhosphorylationKIKRRVKTPYSLKRW
HHHHHCCCCCCCCCC		25.30-
979PhosphorylationKRRVKTPYSLKRWRP
HHHCCCCCCCCCCCC		31.6929514104
980PhosphorylationRRVKTPYSLKRWRPS
HHCCCCCCCCCCCCC		28.72-
1015PhosphorylationAVHSKSSTAVYLAEG
EEEECCCCEEEECCC		27.5124719451
1027PhosphorylationAEGGTATTTVSKDIG
CCCCEEEEEEECCCC		23.8024719451
1028PhosphorylationEGGTATTTVSKDIGM
CCCEEEEEEECCCCC		20.5924719451
1030PhosphorylationGTATTTVSKDIGMNC
CEEEEEEECCCCCCC		23.6329514104
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BMPR2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BMPR2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BMPR2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of BMPR2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BMPR2_MOUSE

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Related Literatures of Post-Translational Modification

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