BMP1_MOUSE - dbPTM
BMP1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BMP1_MOUSE
UniProt AC P98063
Protein Name Bone morphogenetic protein 1
Gene Name Bmp1
Organism Mus musculus (Mouse).
Sequence Length 991
Subcellular Localization Golgi apparatus, trans-Golgi network . Secreted, extracellular space, extracellular matrix . Co-localizes with POSTN in the Golgi.
Protein Description Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD) (By similarity). Responsible for the proteolytic activation of lysyl oxidase LOX..
Protein Sequence MPGVARPPLPLLSLPLLLLLLLLPRAGRPLDLADYTYDLGEEDAPELLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAAVLRQQTARRPSIKAAGNSSALGGQGTSGQPQRESRGRWRGRPRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEVQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPSIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSMDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGGKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDNGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSNLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCEHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFVEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGNRMFLRFYSDNSVQRKGFQASHSTECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYIELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTISKKGFHLRYTSTKFQDTLHSRK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
96N-linked_GlycosylationPSIKAAGNSSALGGQ
CCCEECCCCCCCCCC		28.23-
147N-linked_GlycosylationIPFVIGGNFTGSQRA
EEEEECCCCCHHHHH		26.54-
303PhosphorylationEVNGVKPSIGQRTRL
EECCCCCCCCCCCCC		33.3620139300
337N-linked_GlycosylationTLQDSTGNFSSPEYP
CCCCCCCCCCCCCCC		33.44-
360PhosphorylationCVWRISVTPGEKIIL
EEEEEEECCCCCEEE		20.8420139300
368N-linked_GlycosylationPGEKIILNFTSMDLY
CCCCEEEECCCHHHH		27.95-
370PhosphorylationEKIILNFTSMDLYRS
CCEEEECCCHHHHHH		23.2829895711
371PhosphorylationKIILNFTSMDLYRSR
CEEEECCCHHHHHHC		13.2329895711
375PhosphorylationNFTSMDLYRSRLCWY
ECCCHHHHHHCCCCC		11.4129895711
604N-linked_GlycosylationGGFLTKLNGSITSPG
HCHHHHCCCCCCCCC		43.66-
616NitrationSPGWPKEYPPNKNCI
CCCCCCCCCCCCCCE		30.07-
692PhosphorylationNMRVEFKSDNTVSKK
CEEEEECCCCCCCCC		41.2222871156
695PhosphorylationVEFKSDNTVSKKGFK
EEECCCCCCCCCCEE		31.0222871156
757PhosphorylationAGCEHKVTSTSGTIT
CCCCEECEECCCCCC		30.9622871156
760PhosphorylationEHKVTSTSGTITSPN
CEECEECCCCCCCCC		33.4322871156
762PhosphorylationKVTSTSGTITSPNWP
ECEECCCCCCCCCCC		22.3522871156
764PhosphorylationTSTSGTITSPNWPDK
EECCCCCCCCCCCCC		37.6628066266
765PhosphorylationSTSGTITSPNWPDKY
ECCCCCCCCCCCCCC		16.6328066266
939MethylationGYDSTAPRLGRYCGS
CCCCCCCCHHCCCCC		47.51-
942MethylationSTAPRLGRYCGSGPP
CCCCCHHCCCCCCCH		28.32-
943PhosphorylationTAPRLGRYCGSGPPE
CCCCHHCCCCCCCHH		10.2030635358
946PhosphorylationRLGRYCGSGPPEEVY
CHHCCCCCCCHHHHE		44.5630635358
953PhosphorylationSGPPEEVYSAGDSVL
CCCHHHHEECCCEEE		8.9730635358
954PhosphorylationGPPEEVYSAGDSVLV
CCHHHHEECCCEEEE		30.8330635358
958PhosphorylationEVYSAGDSVLVKFHS
HHEECCCEEEEEECC		19.2130635358
965PhosphorylationSVLVKFHSDDTISKK
EEEEEECCCCCCCCC		40.0730635358
968PhosphorylationVKFHSDDTISKKGFH
EEECCCCCCCCCCEE		31.9430635358
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BMP1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BMP1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BMP1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of BMP1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BMP1_MOUSE

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Related Literatures of Post-Translational Modification

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