| UniProt ID | BIG5_ARATH | |
|---|---|---|
| UniProt AC | F4IXW2 | |
| Protein Name | Brefeldin A-inhibited guanine nucleotide-exchange protein 5 | |
| Gene Name | BIG5 | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 1739 | |
| Subcellular Localization |
Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network membrane Peripheral membrane protein Cytoplasmic side. Early endosome membrane Peripheral membrane protein Cytoplasmic side. Soluble and partially membrane-bound. |
|
| Protein Description | Activates the ARF proteins by exchanging bound GDP for free GTP. Plays a role in vesicular protein sorting. Acts as the major regulator of early endosomal vesicle trafficking but is also involved in the endocytosis process. Target of hopM1, a conserved Pseudomonas syringae virulence protein that directs the protein to its own proteasome-mediated degradation. Plays a broad role in PAMP-triggered immunity (PTI), effector-triggered immunity (ETI), and salicylic acid (SA)-regulated immunity.. | |
| Protein Sequence | MAAGGFLTRAFDTMLKESGGKKFPDLQKAIQAYQDGSKVVTQAAPSSIVESSQAEGGGEKTGVEADEPQKVTSAEVAQQASQSKSETINVSLANAGHTLGGAEVELVLKPLRLAFETKNLKIFDAALDCLHKLIAYDHLEGDPGLDGGKNSAPFTDILNMVCSCVDNSSPDSTVLQVLKVLLTAVASGKFKVHGEPLLGVIRVCYNIALNSKSPINQATSKAMLTQMISIVFRRMETDIVSASSTVSQEEHVSGDTSSPKNEEITAADENEKEMTLGDALTQAKDTTLASVEELHTLVGGADIKGLEAALDKAVHLEDGKKIKRGIELESMSIGQRDALLVFRTLCKMGMKEDSDEVTTKTRILSLELLQGMLEGVSHSFTKNFHFIDSVKAYLSYALLRASVSQSSVIFQYASGIFSVLLLRFRDSLKGEIGIFFPIIVLRSLDNSECPNDQKMGVLRMLEKVCKDPQMLVDVYVNYDCDLEAPNLFERMVTTLSKIAQGSQSADPNPAMASQTASVKGSSLQCLVNVLKSLVDWEKIRREAENSTRNANEDSASTGEPIETKSREDVPSNFEKAKAHKSTMEAAISEFNRNSVKGVEYLIANKLVERNPASVAQFLRSTSSLSKVMIGDYLGQHEEFPLAVMHAYVDSMKFSEMKFHSAIREFLKGFRLPGEAQKIDRIMEKFAERYCADNPGLFKNADTAYVLAYAVIMLNTDAHNPMVWPKMSKSDFTRMNATNDPEDCAPTELLEEIYDSIVQEEIKLKDDDTMKKLSSQRPGGEERGGLVSILNLGLPKRISAADAKSETEDIVRKTQEIFRKHGVKRGVFHTVEQVDIIRPMVEAVGWPLLAAFSVTMEVGDNKPRILLCMEGFKAGIHIAYVLGMDTMRYAFLTSLVRFTFLHAPKEMRSKNVEALRILLGLCDSEPDTLQDTWNAVLECVSRLEFIISTPGIAATVMHGSNQISRDGVVQSLKELAGRPAEQVFVNSVKLPSESVVEFFTALCGVSAEELKQSPARVFSLQKLVEISYYNIARIRMVWARIWSVLAEHFVSAGSHHDEKIAMYAIDSLRQLGMKYLERAELTNFTFQNDILKPFVIIMRNTQSQTIRSLIVDCIVQMIKSKVGSIKSGWRSVFMIFTAAADDEVESIVEKSFENVEQVILEHFDQVIGDCFMDCVNCLIRFANNKASDRISLKAIALLRICEDRLAEGLIPGGVLKPVDGNEDETFDVTEHYWFPMLAGLSDLTSDYRPEVRNCALEVLFDLLNERGNKFSTPFWESIFHRILFPIFDHVSHAGKESLISSGDVKFRETSIHSLQLLCNLFNTFYKEVCFMLPPLLSLLLDCAKKSDQTVVSISLGALVHLIEVGGHQFSEGDWDMLLKSIRDASYTTQPLELLNALSFDNPKKNLVLAGDIEADASDSPRVDRNPDDIKDNGKVSAQASPRIGTHGTSLESGIPPKADGSEGRPSSSGRAQKDVDDVNLQRSQTFGQRFMDNLFLRNLTSQPKSSVAEVTVPSSPYKHEDPTEPDSREEESPALGAIRGKCITQLLLLGAINSIQQKYWSNLKTPQKIAIMDILFSFIEFASSYNSYSNLRTRMNHIPTERPPLNLLRQELEGTTIYLDVLQKTTSGLADDASNSEDRLEGAAEEKLVSFCEQVLKETSDLQSTLGETTNMDVHRVLELRSPVIVKVLEGMCFMNNTIFRKHMREFYPLLTRLVCCEQMEIRGALANLFKAQLKPLLQQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAAGGFLTR ------CCCCHHHHH | 22223895 | ||
| 8 | Phosphorylation | MAAGGFLTRAFDTML CCCCHHHHHHHHHHH | 23328941 | ||
| 237 | Phosphorylation | IVFRRMETDIVSASS HHHHHCCCCCEECCC | 23660473 | ||
| 241 | Phosphorylation | RMETDIVSASSTVSQ HCCCCCEECCCCCCC | 23660473 | ||
| 243 | Phosphorylation | ETDIVSASSTVSQEE CCCCEECCCCCCCCC | 23660473 | ||
| 244 | Phosphorylation | TDIVSASSTVSQEEH CCCEECCCCCCCCCC | 23660473 | ||
| 245 | Phosphorylation | DIVSASSTVSQEEHV CCEECCCCCCCCCCC | 23660473 | ||
| 247 | Phosphorylation | VSASSTVSQEEHVSG EECCCCCCCCCCCCC | 23660473 | ||
| 253 | Phosphorylation | VSQEEHVSGDTSSPK CCCCCCCCCCCCCCC | 23660473 | ||
| 256 | Phosphorylation | EEHVSGDTSSPKNEE CCCCCCCCCCCCCCC | 23660473 | ||
| 257 | Phosphorylation | EHVSGDTSSPKNEEI CCCCCCCCCCCCCCC | 23660473 | ||
| 258 | Phosphorylation | HVSGDTSSPKNEEIT CCCCCCCCCCCCCCC | 27532006 | ||
| 504 | Phosphorylation | KIAQGSQSADPNPAM HHHCCCCCCCCCHHH | 19880383 | ||
| 515 | Phosphorylation | NPAMASQTASVKGSS CHHHHCCCCCCCCHH | 19880383 | ||
| 517 | Phosphorylation | AMASQTASVKGSSLQ HHHCCCCCCCCHHHH | 19880383 | ||
| 554 | Phosphorylation | TRNANEDSASTGEPI CCCCCCCCCCCCCCC | 23776212 | ||
| 556 | Phosphorylation | NANEDSASTGEPIET CCCCCCCCCCCCCCC | 23776212 | ||
| 557 | Phosphorylation | ANEDSASTGEPIETK CCCCCCCCCCCCCCC | 23776212 | ||
| 798 | Phosphorylation | LGLPKRISAADAKSE CCCCCCCCHHHCCCC | 25561503 | ||
| 1299 | Phosphorylation | AGKESLISSGDVKFR CCHHHHHCCCCCCCC | 25561503 | ||
| 1300 | Phosphorylation | GKESLISSGDVKFRE CHHHHHCCCCCCCCC | 25561503 | ||
| 1416 | Phosphorylation | GDIEADASDSPRVDR ECEECCCCCCCCCCC | 23111157 | ||
| 1418 | Phosphorylation | IEADASDSPRVDRNP EECCCCCCCCCCCCH | 30291188 | ||
| 1435 | Phosphorylation | IKDNGKVSAQASPRI CCCCCCCCCCCCCCC | 29654922 | ||
| 1439 | Phosphorylation | GKVSAQASPRIGTHG CCCCCCCCCCCCCCC | 19376835 | ||
| 1460 | Phosphorylation | IPPKADGSEGRPSSS CCCCCCCCCCCCCCC | 25561503 | ||
| 1465 | Phosphorylation | DGSEGRPSSSGRAQK CCCCCCCCCCCCCCC | 29654922 | ||
| 1466 | Phosphorylation | GSEGRPSSSGRAQKD CCCCCCCCCCCCCCC | 30407730 | ||
| 1467 | Phosphorylation | SEGRPSSSGRAQKDV CCCCCCCCCCCCCCC | 25561503 | ||
| 1482 | Phosphorylation | DDVNLQRSQTFGQRF CCCCHHHHHHHHHHH | 28011693 | ||
| 1484 | Phosphorylation | VNLQRSQTFGQRFMD CCHHHHHHHHHHHHH | 23111157 | ||
| 1499 | Phosphorylation | NLFLRNLTSQPKSSV HHHHHCCCCCCCCCC | 23111157 | ||
| 1504 | Phosphorylation | NLTSQPKSSVAEVTV CCCCCCCCCCEEEEC | 23776212 | ||
| 1505 | Phosphorylation | LTSQPKSSVAEVTVP CCCCCCCCCEEEECC | 23776212 | ||
| 1510 | Phosphorylation | KSSVAEVTVPSSPYK CCCCEEEECCCCCCC | 23776212 | ||
| 1513 | Phosphorylation | VAEVTVPSSPYKHED CEEEECCCCCCCCCC | 23776212 | ||
| 1514 | Phosphorylation | AEVTVPSSPYKHEDP EEEECCCCCCCCCCC | 27532006 | ||
| 1516 | Phosphorylation | VTVPSSPYKHEDPTE EECCCCCCCCCCCCC | 23776212 | ||
| 1522 | Phosphorylation | PYKHEDPTEPDSREE CCCCCCCCCCCCCCC | 23776212 | ||
| 1526 | Phosphorylation | EDPTEPDSREEESPA CCCCCCCCCCCCCCC | 23776212 | ||
| 1531 | Phosphorylation | PDSREEESPALGAIR CCCCCCCCCCHHHHH | 23776212 | ||
| 1543 | Phosphorylation | AIRGKCITQLLLLGA HHHHHHHHHHHHHHH | 25368622 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BIG5_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BIG5_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BIG5_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of BIG5_ARATH !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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