BIG3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BIG3_ARATH
• UniProt AC: Q9LPC5
• Protein Name: Brefeldin A-inhibited guanine nucleotide-exchange protein 3
• Gene Name: BIG3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1750
• Subcellular Localization: Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Soluble and partially membrane-bound..
• Protein Description: Activates the ARF proteins by exchanging bound GDP for free GTP. Plays a role in vesicular protein sorting (By similarity). Involved both in the nuclear division phase and in the nuclear fusion phase..
• Protein Sequence: MASTEVDSRLGRVVIPALDKVIKNASWRKHSKLAHECKSVIERLRSPENSSPVADSESGSSIPGPLHDGGAAEYSLAESEIILSPLINASSTGVLKIVDPAVDCIQKLIAHGYVRGEADPTGGPEALLLSKLIETICKCHELDDEGLELLVLKTLLTAVTSISLRIHGDSLLQIVRTCYGIYLGSRNVVNQATAKASLVQMSVIVFRRMEADSSTVPIQPIVVAELMEPMDKSESDPSTTQSVQGFITKIMQDIDGVFNSANAKGTFGGHDGAFETSLPGTANPTDLLDSTDKDMLDAKYWEISMYKSALEGRKGELADGEVEKDDDSEVQIGNKLRRDAFLVFRALCKLSMKTPPKEDPELMRGKIVALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASNLMIIFQLSCSILLSLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPDFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGTVTTLLPPQEAAMKLEAMKCLVAVLRSMGDWVNKQLRLPDPYSAKMLEIVDRNLEEGSHPVENGKGDGGHGGFERSDSQSELSSGNSDALAIEQRRAYKLELQEGISIFNQKPKKGIEFLIKANKVGDSPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFEFQGMEFDEAIRAFLRGFRLPGEAQKIDRIMEKFAERFCKCNPKDFSSADTAYVLAYSVILLNTDAHNPMVKSKMTADGFIRNNRGIDDGKDLPEEYLRALYERISRNEIKMKDDGLGPQQKQPTNSSRLLGLDTILNIVVPRRGDDMNMETSDDLIRHMQERFKEKARKSESVYYAASDVIILRFMVEVCWAPMLAAFSVPLDQSDDAVITTLCLEGFHHAIHVTSVMSLKTHRDAFVTSLAKFTSLHSPADIKQKNIEAIKAIVKLAEEEGNYLQDAWEHILTCVSRFEHLHLLGEGAPPDATFFAFPQTESGNSPLAKPNSVPAIKERAPGKLQYAASAMIRGSYDGSGVAGKASNTVTSEQMNNLISNLNLLEQVGDMSRIFTRSQRLNSEAIIDFVKALCKVSMDELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSDNLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVVVMRKSGAVEIRELIIRCVSQMVLSRVDNVKSGWKSMFMIFTTAAHDAHKNIVFLSFEMVEKIIRDYFPHITETETTTFTDCVNCLVAFTNCKFEKDISLQAIAFLQYCARKLAEGYVGSSLRRNPPLSPQGGKIGKQDSGKFLESDEHLYSWFPLLAGLSELSFDPRAEIRKVALKVLFDTLRNHGDHFSLALWERVFESVLFRIFDYVRQDVDPSEDDSTDQRGYNGEVDQESWLYETCSLALQLVVDLFVNFYKTVNPLLKKVLMLFVSLIKRPHQSLAGAGIAALVRLMRDVGHQFSNEQWLEVVSCIKEAADATSPDFSYVTSEDLMEDVSNEDETNDNSNDALRRRNRQLHAVVTDAKSKASIQIFVIQAVTDIYDMYRMSLTANHMLMLFDAMHGIGSNAHKINADLLLRSKLQELGSSLESQEAPLLRLENESFQTCMTFLDNLISDQPVGYNEAEIESHLISLCREVLEFYINISCSKEQSSRWAVPSGSGKKKELTARAPLVVAAIQTLGNMGESLFKKNLPELFPLIATLISCEHGSGEVQVALSDMLQTSMGPVLLRSCC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASTEVDSR ------CCCCHHHHH		22223895
586	Phosphorylation	GHGGFERSDSQSELS CCCCCCCCCCHHHHC		24601666
588	Phosphorylation	GGFERSDSQSELSSG CCCCCCCCHHHHCCC		24601666
590	Phosphorylation	FERSDSQSELSSGNS CCCCCCHHHHCCCCC		24601666
593	Phosphorylation	SDSQSELSSGNSDAL CCCHHHHCCCCCCCH		23776212
594	Phosphorylation	DSQSELSSGNSDALA CCHHHHCCCCCCCHH		19376835
597	Phosphorylation	SELSSGNSDALAIEQ HHHCCCCCCCHHHHH		23776212
985	Phosphorylation	EGAPPDATFFAFPQT CCCCCCCEEEECCCC		27643528
992	Phosphorylation	TFFAFPQTESGNSPL EEEECCCCCCCCCCC		27643528
994	Phosphorylation	FAFPQTESGNSPLAK EECCCCCCCCCCCCC		27643528
997	Phosphorylation	PQTESGNSPLAKPNS CCCCCCCCCCCCCCC		27643528
1004	Phosphorylation	SPLAKPNSVPAIKER CCCCCCCCCCCHHHC		27643528
1021	Phosphorylation	GKLQYAASAMIRGSY CCHHHHHHHHHCCCC		25561503
1307	Phosphorylation	LRRNPPLSPQGGKIG HCCCCCCCCCCCCCC		23776212
1318	Phosphorylation	GKIGKQDSGKFLESD CCCCCCCCCCCCCCC		25561503
1395	Phosphorylation	VRQDVDPSEDDSTDQ HHCCCCCCCCCCCCC		29654922
1399	Phosphorylation	VDPSEDDSTDQRGYN CCCCCCCCCCCCCCC		29654922
1505	Phosphorylation	SPDFSYVTSEDLMED CCCCCCCCHHHHHHH		30407730
1506	Phosphorylation	PDFSYVTSEDLMEDV CCCCCCCHHHHHHHC		30407730
1514	Phosphorylation	EDLMEDVSNEDETND HHHHHHCCCCCCCCC		30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BIG3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BIG3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BIG3_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of BIG3_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.