BIG2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BIG2_ARATH
• UniProt AC: Q9LZX8
• Protein Name: Brefeldin A-inhibited guanine nucleotide-exchange protein 2
• Gene Name: BIG2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1793
• Subcellular Localization: Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Soluble and partially membrane-bound..
• Protein Description: Activates the ARF proteins by exchanging bound GDP for free GTP. Plays a role in vesicular protein sorting (By similarity)..
• Protein Sequence: MASSEADSRLSRVVTPALEKIVKNASWRKHSKLANECKAVIERLNSLQKSPPPSSSAATDSESESSVPGPLNDGGSIEYSLADSELIFSPLINACGTGLAKIIEPAIDCIQKLIAHGYIRGESDPSGGAESLLLFKLIDSVCKCHDLGDESIELPVLKTLLSAINSISLRIHGKCLLLVVRTCYDIYLGSKNVVNQTTAKASLIQILVIVFRRMEADSSTVPIQPIVVAELMEPLEKSDADGTMTQFVQGFITKIMQDIDGVLNPTMSGSGSGSGSGGQDGAYGTTTVETTNPTDLLDSTDKDMLDAKYWEISMYKSALEGRKGELTDGDAERDDDLEVQIENKLRRDACLVFRALCKLSMKAPPKESSADPQSMRGKILALELLKILLENAGAVFRTSEKFSADIKQFLCLSLLKNSASTLMIIFQLSCSIFISLVARFRAGLKAEIGVFFPMIVLRVVENVAQPNFQQKMIVLRFLDKLCLDSQILVDIFLNYDCDVNSSNIFERMVNGLLKTAQGVPPGTATTLMPPQEAAMKLEAMKCLVAILKSMGDWLNKQLRLPVSNSLNKSDVIEIDLGPGSPQLANGNADESADGSDTYSESSGGTSDALAIEQRRAYKLELQEGISLFNRKPTKGIEFLINAGKVGESPEEIAGFLKDASGLNKTLIGDYLGEREDLALKVMHAYVDSFDFRGMEFDEAIRTFLEGFRLPGEAQKIDRIMEKFAERYCKCNPKVFTSADSAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPADYMRSLYERITKHEIKMKEDDLRLQQKQYANSNRMLGLDGILNIVIRKQWGDSYAETSDDLMKHMQEQFKEKARKSESTYYAATDVVILRFMIEACWAPMLAAFSVPLDQSDDLIVINICLEGFHHAIHATSLMSMKTHRDAFVTSLAKFTSLHSPADIKQRNIEAIKAILRLADEEGNYLQDAWEHILTCVSRFEQLHLLGEGAPPDATFFASKQNESEKSKQPKQYILPVLKRKGPGKSQYAATGVLRGSYDSMSLGGKGSKNVRQEQMSSIVSNLNLLEQVGEMNQVFSQSQKLNSEAIIDFVKALCKVSMDELRSPSNPRVFSLTKIVEIAHYNMNRIRLVWSSIWQVLSGFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMTPFVIVMRRSNDVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVFLSFEIIEKIIREYFPYITETETTTFTDCVNCLVAFTNNRFSKDISLSSIAFLRYCATKLAEGDLNSPSTNKYKGTSGKIPQSSLHSGKSGKQENGEIVNNNHLYFWFPLLSGLSELSFDPRPEIRKSALQIMFDTLRNHGHLFSLPLWEKVFESVLFPIFDYVRHSIDPSGEDESADQGSSGGEVDELDHDAWLYETCTLALQLVVDLFVKFYTTVNPLLEKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSDADGLFSEEKWLEVVSALKEAAKTTCPDFSYFLSEEYVARSQRSALNIQNSNAESAAPTATDGNEESQRTATHLYAAISDAKCRAAVQLLLIQAVMEIYNMYRPQLSAKNTLVLVDALHGVALHAHGINSNTILRSRLQELGPMTQMQDPPLLRLENESYQICLTFLQNLVADKTKKEEEEEEEEIESLLVNICQEVLNFYIETSSSAKKLQSESSRASEYRWRIPLGSGKRRELSARAPLIVATLQAMCTLDEASFEKNLKCLFPLLANLISCEHGSNEVQTALADMLGLSVGPVLLQWC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASSEADSR ------CCCHHHHHH		-
515	Phosphorylation	MVNGLLKTAQGVPPG HHHHHHHHCCCCCCC		28295753
523	Phosphorylation	AQGVPPGTATTLMPP CCCCCCCCCCCCCCH		28295753
525	Phosphorylation	GVPPGTATTLMPPQE CCCCCCCCCCCCHHH		28295753
526	Phosphorylation	VPPGTATTLMPPQEA CCCCCCCCCCCHHHH		28295753
549	Phosphorylation	CLVAILKSMGDWLNK HHHHHHHHCHHHHHH		19880383
595	Phosphorylation	ADESADGSDTYSESS CCCCCCCCCCCCCCC		-
1307	Phosphorylation	LAEGDLNSPSTNKYK HHHCCCCCCCCCCCC		19880383
1309	Phosphorylation	EGDLNSPSTNKYKGT HCCCCCCCCCCCCCC		19880383
1310	Phosphorylation	GDLNSPSTNKYKGTS CCCCCCCCCCCCCCC		25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BIG2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BIG2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BIG2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of BIG2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.