BHMT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BHMT1_MOUSE
• UniProt AC: O35490
• Protein Name: Betaine--homocysteine S-methyltransferase 1
• Gene Name: Bhmt
• Organism: Mus musculus (Mouse).
• Sequence Length: 407
• Subcellular Localization: Cytoplasm.
• Protein Description: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline..
• Protein Sequence: MAPVAGKKAKKGILERLNAGEVVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVAEKISGQKVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSEVEVKKIFRQQLEVFMKKNVDFLIAEYFEHVEEAVWAVEALKASGKPVAATMCIGPEGDLHGVPPGECAVRLVKAGASIVGVNCHFDPSVSLQTVKLMKEGLEAARLKAYLMSQPLAYHTPDCGKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARKEYWQNLRIASGRPYNPSMSRPDAWGVTKGAAELMQQKEATTEQQLRELFEKQKFKSAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Sumoylation	-MAPVAGKKAKKGIL -CCCCCCHHHHCCHH	39.56	28289178
11	Malonylation	VAGKKAKKGILERLN CCCHHHHCCHHHHHC	56.92	26073543
11	Ubiquitination	VAGKKAKKGILERLN CCCHHHHCCHHHHHC	56.92	27667366
35	Ubiquitination	GFVFALEKRGYVKAG CEEEEEEECCCEECC	52.56	22790023
40	Acetylation	LEKRGYVKAGPWTPE EEECCCEECCCCCHH	38.86	23806337
40	Malonylation	LEKRGYVKAGPWTPE EEECCCEECCCCCHH	38.86	26320211
40	Succinylation	LEKRGYVKAGPWTPE EEECCCEECCCCCHH	38.86	-
40	Succinylation	LEKRGYVKAGPWTPE EEECCCEECCCCCHH	38.86	23806337
40	Ubiquitination	LEKRGYVKAGPWTPE EEECCCEECCCCCHH	38.86	27667366
45	Phosphorylation	YVKAGPWTPEAAVEH CEECCCCCHHHHHHC	17.87	22324799
75	Phosphorylation	SNVMQTFTFYASEDK CCEEEEEEEEECHHH	21.08	23140645
77	Phosphorylation	VMQTFTFYASEDKLE EEEEEEEEECHHHHH	13.22	23140645
79	Phosphorylation	QTFTFYASEDKLENR EEEEEEECHHHHHHC	34.64	22817900
82	Acetylation	TFYASEDKLENRGNY EEEECHHHHHHCCCC	54.36	23954790
82	Malonylation	TFYASEDKLENRGNY EEEECHHHHHHCCCC	54.36	26073543
82	Ubiquitination	TFYASEDKLENRGNY EEEECHHHHHHCCCC	54.36	-
93	Acetylation	RGNYVAEKISGQKVN CCCCEEHHHCCCCHH	32.22	23864654
93	Malonylation	RGNYVAEKISGQKVN CCCCEEHHHCCCCHH	32.22	26320211
93	Succinylation	RGNYVAEKISGQKVN CCCCEEHHHCCCCHH	32.22	-
93	Succinylation	RGNYVAEKISGQKVN CCCCEEHHHCCCCHH	32.22	23806337
93	Ubiquitination	RGNYVAEKISGQKVN CCCCEEHHHCCCCHH	32.22	27667366
98	Acetylation	AEKISGQKVNEAACD EHHHCCCCHHHHHHH	51.02	23806337
98	Glutarylation	AEKISGQKVNEAACD EHHHCCCCHHHHHHH	51.02	24703693
98	Malonylation	AEKISGQKVNEAACD EHHHCCCCHHHHHHH	51.02	26073543
98	Succinylation	AEKISGQKVNEAACD EHHHCCCCHHHHHHH	51.02	-
98	Succinylation	AEKISGQKVNEAACD EHHHCCCCHHHHHHH	51.02	23806337
98	Ubiquitination	AEKISGQKVNEAACD EHHHCCCCHHHHHHH	51.02	-
104	S-palmitoylation	QKVNEAACDIARQVA CCHHHHHHHHHHHHC	5.11	28526873
123	Phosphorylation	ALVAGGVSQTPSYLS CEEECCCCCCCCCHH	31.45	23984901
125	Phosphorylation	VAGGVSQTPSYLSCK EECCCCCCCCCHHCC	13.49	23984901
127	Phosphorylation	GGVSQTPSYLSCKSE CCCCCCCCCHHCCCH	41.93	23984901
128	Phosphorylation	GVSQTPSYLSCKSEV CCCCCCCCHHCCCHH	12.11	23984901
130	Phosphorylation	SQTPSYLSCKSEVEV CCCCCCHHCCCHHHH	15.97	23984901
131	S-nitrosylation	QTPSYLSCKSEVEVK CCCCCHHCCCHHHHH	5.33	22178444
131	S-palmitoylation	QTPSYLSCKSEVEVK CCCCCHHCCCHHHHH	5.33	28526873
132	Acetylation	TPSYLSCKSEVEVKK CCCCHHCCCHHHHHH	46.40	23864654
132	Malonylation	TPSYLSCKSEVEVKK CCCCHHCCCHHHHHH	46.40	26320211
132	Ubiquitination	TPSYLSCKSEVEVKK CCCCHHCCCHHHHHH	46.40	-
138	Acetylation	CKSEVEVKKIFRQQL CCCHHHHHHHHHHHH	27.01	23201123
150	Acetylation	QQLEVFMKKNVDFLI HHHHHHHHCCCCHHH	29.72	23864654
150	Malonylation	QQLEVFMKKNVDFLI HHHHHHHHCCCCHHH	29.72	26073543
150	Ubiquitination	QQLEVFMKKNVDFLI HHHHHHHHCCCCHHH	29.72	-
179	Malonylation	EALKASGKPVAATMC HHHHHCCCCEEEEEE	33.55	26320211
207	Acetylation	ECAVRLVKAGASIVG HHHHHHHHCCCCEEE	45.77	23806337
207	Malonylation	ECAVRLVKAGASIVG HHHHHHHHCCCCEEE	45.77	26320211
207	Succinylation	ECAVRLVKAGASIVG HHHHHHHHCCCCEEE	45.77	-
207	Ubiquitination	ECAVRLVKAGASIVG HHHHHHHHCCCCEEE	45.77	-
217	S-nitrosylation	ASIVGVNCHFDPSVS CCEEEEECCCCCCCC	2.92	22178444
217	S-palmitoylation	ASIVGVNCHFDPSVS CCEEEEECCCCCCCC	2.92	28526873
222	Phosphorylation	VNCHFDPSVSLQTVK EECCCCCCCCHHHHH	26.61	25521595
224	Phosphorylation	CHFDPSVSLQTVKLM CCCCCCCCHHHHHHH	21.06	23984901
227	Phosphorylation	DPSVSLQTVKLMKEG CCCCCHHHHHHHHHH	25.54	23984901
229	Malonylation	SVSLQTVKLMKEGLE CCCHHHHHHHHHHHH	46.37	26320211
229	Ubiquitination	SVSLQTVKLMKEGLE CCCHHHHHHHHHHHH	46.37	-
232	Acetylation	LQTVKLMKEGLEAAR HHHHHHHHHHHHHHH	60.09	23954790
232	Glutarylation	LQTVKLMKEGLEAAR HHHHHHHHHHHHHHH	60.09	24703693
232	Malonylation	LQTVKLMKEGLEAAR HHHHHHHHHHHHHHH	60.09	26073543
232	Succinylation	LQTVKLMKEGLEAAR HHHHHHHHHHHHHHH	60.09	-
232	Succinylation	LQTVKLMKEGLEAAR HHHHHHHHHHHHHHH	60.09	23806337
232	Ubiquitination	LQTVKLMKEGLEAAR HHHHHHHHHHHHHHH	60.09	27667366
241	Acetylation	GLEAARLKAYLMSQP HHHHHHHHHHHHHCC	29.45	23806337
241	Malonylation	GLEAARLKAYLMSQP HHHHHHHHHHHHHCC	29.45	26320211
241	Succinylation	GLEAARLKAYLMSQP HHHHHHHHHHHHHCC	29.45	-
241	Succinylation	GLEAARLKAYLMSQP HHHHHHHHHHHHHCC	29.45	23806337
241	Ubiquitination	GLEAARLKAYLMSQP HHHHHHHHHHHHHCC	29.45	-
243	Phosphorylation	EAARLKAYLMSQPLA HHHHHHHHHHHCCCC	11.01	25521595
246	Phosphorylation	RLKAYLMSQPLAYHT HHHHHHHHCCCCCCC	26.50	23567750
253	Phosphorylation	SQPLAYHTPDCGKQG HCCCCCCCCCCCCCC	14.24	17242355
256	S-nitrosylation	LAYHTPDCGKQGFID CCCCCCCCCCCCCCC	8.47	22178444
256	S-palmitoylation	LAYHTPDCGKQGFID CCCCCCCCCCCCCCC	8.47	28526873
258	Acetylation	YHTPDCGKQGFIDLP CCCCCCCCCCCCCCC	54.29	23864654
283	Acetylation	ATRWDIQKYAREAYN CCHHHHHHHHHHHHH	41.01	23864654
283	Glutarylation	ATRWDIQKYAREAYN CCHHHHHHHHHHHHH	41.01	24703693
283	Malonylation	ATRWDIQKYAREAYN CCHHHHHHHHHHHHH	41.01	26073543
283	Succinylation	ATRWDIQKYAREAYN CCHHHHHHHHHHHHH	41.01	-
283	Ubiquitination	ATRWDIQKYAREAYN CCHHHHHHHHHHHHH	41.01	27667366
289	Phosphorylation	QKYAREAYNLGVRYI HHHHHHHHHCCCCCC	13.23	29472430
299	S-nitrosylation	GVRYIGGCCGFEPYH CCCCCCCCCCCCHHH	1.40	22178444
299	S-palmitoylation	GVRYIGGCCGFEPYH CCCCCCCCCCCCHHH	1.40	28526873
300	S-nitrosylation	VRYIGGCCGFEPYHI CCCCCCCCCCCHHHH	8.71	22178444
300	S-palmitoylation	VRYIGGCCGFEPYHI CCCCCCCCCCCHHHH	8.71	28526873
330	Phosphorylation	PASEKHGSWGSGLDM CHHHCCCCCCCCCCC	28.16	21082442
333	Phosphorylation	EKHGSWGSGLDMHTK HCCCCCCCCCCCCCH	29.89	26643407
339	Phosphorylation	GSGLDMHTKPWIRAR CCCCCCCCHHHHHHH	31.97	23567750
340	Acetylation	SGLDMHTKPWIRARA CCCCCCCHHHHHHHH	24.55	23806337
340	Succinylation	SGLDMHTKPWIRARA CCCCCCCHHHHHHHH	24.55	-
340	Succinylation	SGLDMHTKPWIRARA CCCCCCCHHHHHHHH	24.55	23806337
340	Ubiquitination	SGLDMHTKPWIRARA CCCCCCCHHHHHHHH	24.55	-
349	Acetylation	WIRARARKEYWQNLR HHHHHHHHHHHHHCH	54.92	23806337
349	Glutarylation	WIRARARKEYWQNLR HHHHHHHHHHHHHCH	54.92	24703693
349	Malonylation	WIRARARKEYWQNLR HHHHHHHHHHHHHCH	54.92	26073543
349	Succinylation	WIRARARKEYWQNLR HHHHHHHHHHHHHCH	54.92	-
349	Ubiquitination	WIRARARKEYWQNLR HHHHHHHHHHHHHCH	54.92	27667366
363	Phosphorylation	RIASGRPYNPSMSRP HHCCCCCCCCCCCCC	38.04	17242355
377	Acetylation	PDAWGVTKGAAELMQ CCHHHCCHHHHHHHH	44.11	23806337
377	Malonylation	PDAWGVTKGAAELMQ CCHHHCCHHHHHHHH	44.11	26320211
377	Succinylation	PDAWGVTKGAAELMQ CCHHHCCHHHHHHHH	44.11	-
377	Succinylation	PDAWGVTKGAAELMQ CCHHHCCHHHHHHHH	44.11	23806337
377	Ubiquitination	PDAWGVTKGAAELMQ CCHHHCCHHHHHHHH	44.11	27667366
383	Sulfoxidation	TKGAAELMQQKEATT CHHHHHHHHHHHCCH	2.74	21406390
386	Acetylation	AAELMQQKEATTEQQ HHHHHHHHHCCHHHH	32.21	23806337
386	Malonylation	AAELMQQKEATTEQQ HHHHHHHHHCCHHHH	32.21	26320211
386	Succinylation	AAELMQQKEATTEQQ HHHHHHHHHCCHHHH	32.21	-
386	Ubiquitination	AAELMQQKEATTEQQ HHHHHHHHHCCHHHH	32.21	27667366
389	Phosphorylation	LMQQKEATTEQQLRE HHHHHHCCHHHHHHH	31.77	25521595
390	Phosphorylation	MQQKEATTEQQLREL HHHHHCCHHHHHHHH	38.55	25521595
400	Malonylation	QLRELFEKQKFKSAQ HHHHHHHHHHHHHCC	51.99	26320211
400	Ubiquitination	QLRELFEKQKFKSAQ HHHHHHHHHHHHHCC	51.99	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BHMT1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BHMT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BHMT1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BHMT1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.