BEND4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BEND4_HUMAN
• UniProt AC: Q6ZU67
• Protein Name: BEN domain-containing protein 4
• Gene Name: BEND4
• Organism: Homo sapiens (Human).
• Sequence Length: 534
• Protein Sequence: MEEEMQPAEEGPSVPKIYKQRSPYSVLKTFPSKRPALAKRYERPTLVELPHVRAPPPPPPPFAPHAAVSISSSEPPPQQFQAQSSYPPGPGRAAAAASSSSPSCTPATSQGHLRTPAQPPPASPAASSSSSFAAVVRYGPGAAAAAGTGGTGSDSASLELSAESRMILDAFAQQCSRVLSLLNCGGKLLDSNHSQSMISCVKQEGSSYNERQEHCHIGKGVHSQTSDNVDIEMQYMQRKQQTSAFLRVFTDSLQNYLLSGSFPTPNPSSASEYGHLADVDPLSTSPVHTLGGWTSPATSESHGHPSSSTLPEEEEEEDEEGYCPRCQELEQEVISLQQENEELRRKLESIPVPCQTVLDYLKMVLQHHNQLLIPQPADQPTEGSKQLLNNYPVYITSKQWDEAVNSSKKDGRRLLRYLIRFVFTTDELKYSCGLGKRKRSVQSGETGPERRPLDPVKVTCLREFIRMHCTSNPDWWMPSEEQINKVFSDAVGHARQGRAVGTFLHNGGSFYEGIDHQASQDEVFNKSSQDGSGD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
98	Phosphorylation	GRAAAAASSSSPSCT CHHHHHHCCCCCCCC	26.48	30108239
99	Phosphorylation	RAAAAASSSSPSCTP HHHHHHCCCCCCCCC	30.06	27732954
100	Phosphorylation	AAAAASSSSPSCTPA HHHHHCCCCCCCCCC	43.71	27732954
101	Phosphorylation	AAAASSSSPSCTPAT HHHHCCCCCCCCCCC	23.84	27732954
103	Phosphorylation	AASSSSPSCTPATSQ HHCCCCCCCCCCCCC	32.35	27732954
105	Phosphorylation	SSSSPSCTPATSQGH CCCCCCCCCCCCCCC	21.94	27732954
108	Phosphorylation	SPSCTPATSQGHLRT CCCCCCCCCCCCCCC	23.84	30108239
109	Phosphorylation	PSCTPATSQGHLRTP CCCCCCCCCCCCCCC	35.95	30108239
123	Phosphorylation	PAQPPPASPAASSSS CCCCCCCCCCCCCCC	22.35	-
187	Ubiquitination	SLLNCGGKLLDSNHS HHHHCCCEECCCCCC	31.03	-
202	Ubiquitination	QSMISCVKQEGSSYN HHHHHHHHHCCCCHH	47.13	29967540
239	Ubiquitination	EMQYMQRKQQTSAFL HHHHHHHHHHHHHHH	29.84	-
301	Phosphorylation	TSPATSESHGHPSSS CCCCCHHCCCCCCCC	34.24	24275569
309	Phosphorylation	HGHPSSSTLPEEEEE CCCCCCCCCCHHHHH	48.56	24275569
346	Ubiquitination	ENEELRRKLESIPVP HCHHHHHHHHCCCCC	50.61	-
385	Ubiquitination	DQPTEGSKQLLNNYP CCCCCHHHHHHHCCC	56.68	29967540
394	Phosphorylation	LLNNYPVYITSKQWD HHHCCCEEEEEHHHH	8.25	-
396	Phosphorylation	NNYPVYITSKQWDEA HCCCEEEEEHHHHHH	16.51	-
397	Phosphorylation	NYPVYITSKQWDEAV CCCEEEEEHHHHHHH	17.19	-
425	Phosphorylation	LIRFVFTTDELKYSC HHHHHCCCCHHHHCC	18.93	-
436	Acetylation	KYSCGLGKRKRSVQS HHCCCCCCCCCCCCC	60.84	25953088
440	Phosphorylation	GLGKRKRSVQSGETG CCCCCCCCCCCCCCC	27.78	26852163
443	Phosphorylation	KRKRSVQSGETGPER CCCCCCCCCCCCCCC	36.12	26852163
479	Phosphorylation	NPDWWMPSEEQINKV CCCCCCCCHHHHHHH	37.35	29759185
519	Phosphorylation	EGIDHQASQDEVFNK CCCCCCCCHHHHHHH	31.43	17525332
528	Phosphorylation	DEVFNKSSQDGSGD- HHHHHHCCCCCCCC-	33.62	17525332

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BEND4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BEND4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BEND4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of BEND4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-519 AND SER-528, ANDMASS SPECTROMETRY.
PubMed: 17525332