BEND3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BEND3_MOUSE
• UniProt AC: Q6PAL0
• Protein Name: BEN domain-containing protein 3
• Gene Name: Bend3
• Organism: Mus musculus (Mouse).
• Sequence Length: 825
• Subcellular Localization: Nucleus . Nucleus, nucleolus . In the nucleus, observed in heterochromatic foci containing CBX1, CBX3, CBX5 and histone H3 trimethylated at 'Lys-9'. Released from chromatin during decondensation. Association with heterochromatin does not depend on su
• Protein Description: Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (By similarity). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites. [PubMed: 25457167 Stimulates the ERCC6L translocase and ATPase activities (By similarity]
• Protein Sequence: MNSTEISEDVEEVLKNNPVKAEGSDATLDCSRNSRASEKHLLESVLTALHDSSKRKQLDSDGQPDSVPSVKRRRLIPEALLAGMRTRENSSPCQGNGEPASRGRSGSCAWPAEEEPSTEATVPSYKKPLYGISHKIMEKKNPPSGDLLSPYELFEKANSSSGPSPLRLLSESQKRECGVGVATDGDLNIYFLIQKMFYMLNGLTTNMSQLHSKMDLLSLEVSRVKKQVSPSELVAKFQPPPEYQLTASELKQIAEQSLSCGDLACRLLLQLFPELFSDVDFSRGCSACGFAAKRKLESLHLQLIRNYVEVYYPNVKDTAVWQAECLPQLNDFFSRFWAQREMEDSQPGGQVTNFFEADQVDAGHFLDNKDQEEALSLDRSSTIASDHVVDTQDLTEFLDEASSPGEFAVFLLHRLFPELFDHRKLGEQYSCYGDGGKQELDPQRLQIIRNYTEIYFPDMQEEEAWLQQCAQRINDELEGLGLEGGSEGEAPRDDCYDSSSLPDDISVVKVEDNFEGERPGRRSKKIWLVPIDFDKLEIPQPDFEMPGSDCLLSKEQLRSIYESSLSIGNFASRLLVHLFPELFTHENLRKQYNCSGSLGKKQLDPARIRLIRHYVQLLYPRAKNDRVWTLEFVGKLDERCRRRDTEQRRSYQQQRKVHVPGPECRDLASYAINPERFREEFEGPPLPPERSSKDFCKIPLDELVVPSPDFPVPSPYLLSDKEVREIVQQSLSVGNFAARLLVRLFPELFTTENLRLQYNHSGACNKKQLDPTRLRLIRHYVEAVYPVEKMEEVWHYECIPSIDERCRRPNRKKCDILKKAKKVEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Phosphorylation	ALLAGMRTRENSSPC HHHHCCCCCCCCCCC	33.18	23984901
90	Phosphorylation	GMRTRENSSPCQGNG CCCCCCCCCCCCCCC	30.79	23984901
91	Phosphorylation	MRTRENSSPCQGNGE CCCCCCCCCCCCCCC	41.08	23984901
105	Phosphorylation	EPASRGRSGSCAWPA CCCCCCCCCCCCCCC	37.57	25619855
107	Phosphorylation	ASRGRSGSCAWPAEE CCCCCCCCCCCCCCC	11.25	25619855
130	Phosphorylation	PSYKKPLYGISHKIM CCCCCCCCCCCHHHH	22.42	-
133	Phosphorylation	KKPLYGISHKIMEKK CCCCCCCCHHHHHHC	17.86	-
149	Phosphorylation	PPSGDLLSPYELFEK CCCCCCCCHHHHHHH	32.50	25266776
159	Phosphorylation	ELFEKANSSSGPSPL HHHHHHCCCCCCCHH	30.64	26643407
160	Phosphorylation	LFEKANSSSGPSPLR HHHHHCCCCCCCHHH	38.84	26643407
161	Phosphorylation	FEKANSSSGPSPLRL HHHHCCCCCCCHHHH	55.32	28066266
164	Phosphorylation	ANSSSGPSPLRLLSE HCCCCCCCHHHHCCH	39.84	29895711
170	Phosphorylation	PSPLRLLSESQKREC CCHHHHCCHHHCCCC	39.53	25266776
376	Phosphorylation	KDQEEALSLDRSSTI CCHHHHHHCCCCCCH	34.96	21149613
486	Phosphorylation	GLGLEGGSEGEAPRD HCCCCCCCCCCCCCC	53.97	27087446
496	Phosphorylation	EAPRDDCYDSSSLPD CCCCCCCCCCCCCCC	26.34	25619855
498	Phosphorylation	PRDDCYDSSSLPDDI CCCCCCCCCCCCCCE	8.71	25619855
499	Phosphorylation	RDDCYDSSSLPDDIS CCCCCCCCCCCCCEE	32.75	25619855
500	Phosphorylation	DDCYDSSSLPDDISV CCCCCCCCCCCCEEE	48.12	25619855
506	Phosphorylation	SSLPDDISVVKVEDN CCCCCCEEEEEEECC	28.05	28066266
707	Phosphorylation	LDELVVPSPDFPVPS HHHCCCCCCCCCCCC	26.03	26745281
714	Phosphorylation	SPDFPVPSPYLLSDK CCCCCCCCCCCCCHH	26.81	26745281
716	Phosphorylation	DFPVPSPYLLSDKEV CCCCCCCCCCCHHHH	25.31	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BEND3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
20	K	Sumoylation	Sumoylated at Lys-20 by SUMO1 and at Lys-509 by SUMO1, SUMO2 and SUMO3.	-
20	K	Sumoylation	Sumoylation probably occurs sequentially, with that of Lys-20 preceding that of Lys-509.	-
509	K	Sumoylation	Sumoylated at Lys-20 by SUMO1 and at Lys-509 by SUMO1, SUMO2 and SUMO3.	-
509	K	Sumoylation	Sumoylation probably occurs sequentially, with that of Lys-20 preceding that of Lys-509.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BEND3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BEND3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.