dbPTM

BCL9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BCL9_HUMAN
UniProt AC	O00512
Protein Name	B-cell CLL/lymphoma 9 protein
Gene Name	BCL9
Organism	Homo sapiens (Human).
Sequence Length	1426
Subcellular Localization	Nucleus.
Protein Description	Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity)..
Protein Sequence	MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDSDIKECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Acetylation	-MHSSNPKVRSSPSG -CCCCCCCCCCCCCC	55.31	25953088
10	Phosphorylation	SSNPKVRSSPSGNTQ CCCCCCCCCCCCCCC	49.98	20363803
11	Phosphorylation	SNPKVRSSPSGNTQS CCCCCCCCCCCCCCC	16.72	25849741
13	Phosphorylation	PKVRSSPSGNTQSSP CCCCCCCCCCCCCCC	46.77	23663014
16	Phosphorylation	RSSPSGNTQSSPKSK CCCCCCCCCCCCCCC	33.10	23663014
18	Phosphorylation	SPSGNTQSSPKSKQE CCCCCCCCCCCCCCC	46.71	20363803
19	Phosphorylation	PSGNTQSSPKSKQEV CCCCCCCCCCCCCCE	26.91	21955146
22	Phosphorylation	NTQSSPKSKQEVMVR CCCCCCCCCCCEEEC	42.85	26074081
32	Phosphorylation	EVMVRPPTVMSPSGN CEEECCCCEECCCCC	31.37	29255136
35	Phosphorylation	VRPPTVMSPSGNPQL ECCCCEECCCCCCCC	16.16	29255136
37	Phosphorylation	PPTVMSPSGNPQLDS CCCEECCCCCCCCCH	43.85	29255136
44	Phosphorylation	SGNPQLDSKFSNQGK CCCCCCCHHHCCCCC	44.16	29255136
47	Phosphorylation	PQLDSKFSNQGKQGG CCCCHHHCCCCCCCC	31.79	-
51	Acetylation	SKFSNQGKQGGSASQ HHHCCCCCCCCCCCC	35.69	26051181
55	Phosphorylation	NQGKQGGSASQSQPS CCCCCCCCCCCCCCC	31.41	25262027
57	Phosphorylation	GKQGGSASQSQPSPC CCCCCCCCCCCCCCC	31.87	25262027
59	Phosphorylation	QGGSASQSQPSPCDS CCCCCCCCCCCCCCC	41.38	28450419
62	Phosphorylation	SASQSQPSPCDSKSG CCCCCCCCCCCCCCC	30.44	25849741
66	Phosphorylation	SQPSPCDSKSGGHTP CCCCCCCCCCCCCCC	35.12	18491316
67	Acetylation	QPSPCDSKSGGHTPK CCCCCCCCCCCCCCC	39.61	26051181
68	Phosphorylation	PSPCDSKSGGHTPKA CCCCCCCCCCCCCCC	54.69	24114839
72	Phosphorylation	DSKSGGHTPKALPGP CCCCCCCCCCCCCCC	29.74	23312004
82	Phosphorylation	ALPGPGGSMGLKNGA CCCCCCCCCCCCCCC	18.65	23312004
86	Acetylation	PGGSMGLKNGAGNGA CCCCCCCCCCCCCCC	47.83	25953088
94	Acetylation	NGAGNGAKGKGKRER CCCCCCCCCCCHHCC	63.65	26051181
96	Acetylation	AGNGAKGKGKRERSI CCCCCCCCCHHCCCC	61.63	26051181
98	Acetylation	NGAKGKGKRERSISA CCCCCCCHHCCCCCC	55.35	26051181
102	Phosphorylation	GKGKRERSISADSFD CCCHHCCCCCCCCCC	19.01	30266825
104	Phosphorylation	GKRERSISADSFDQR CHHCCCCCCCCCCCC	27.54	19664994
107	Phosphorylation	ERSISADSFDQRDPG CCCCCCCCCCCCCCC	30.36	30266825
115	Phosphorylation	FDQRDPGTPNDDSDI CCCCCCCCCCCCCHH	25.06	23401153
120	Phosphorylation	PGTPNDDSDIKECNS CCCCCCCCHHHHHCC	44.06	30278072
127	Phosphorylation	SDIKECNSADHIKSQ CHHHHHCCCHHHHCC	46.89	28985074
133	Phosphorylation	NSADHIKSQDSQHTP CCCHHHHCCCCCCCC	38.32	26074081
136	Phosphorylation	DHIKSQDSQHTPHSM HHHHCCCCCCCCCCC	19.07	26074081
139	Phosphorylation	KSQDSQHTPHSMTPS HCCCCCCCCCCCCCC	18.30	26074081
142	Phosphorylation	DSQHTPHSMTPSNAT CCCCCCCCCCCCCCC	26.09	26074081
144	Phosphorylation	QHTPHSMTPSNATAP CCCCCCCCCCCCCCC	26.95	26074081
146	Phosphorylation	TPHSMTPSNATAPRS CCCCCCCCCCCCCCC	29.90	26074081
149	Phosphorylation	SMTPSNATAPRSSTP CCCCCCCCCCCCCCC	41.25	26074081
153	Phosphorylation	SNATAPRSSTPSHGQ CCCCCCCCCCCCCCC	37.19	25159151
154	Phosphorylation	NATAPRSSTPSHGQT CCCCCCCCCCCCCCC	45.69	25159151
155	Phosphorylation	ATAPRSSTPSHGQTT CCCCCCCCCCCCCCC	30.01	23401153
157	Phosphorylation	APRSSTPSHGQTTAT CCCCCCCCCCCCCCC	40.10	21955146
161	Phosphorylation	STPSHGQTTATEPTP CCCCCCCCCCCCCCC	24.00	21955146
162	Phosphorylation	TPSHGQTTATEPTPA CCCCCCCCCCCCCCC	24.56	21955146
164	Phosphorylation	SHGQTTATEPTPAQK CCCCCCCCCCCCCCC	40.17	23403867
167	Phosphorylation	QTTATEPTPAQKTPA CCCCCCCCCCCCCCC	25.64	29396449
171	Acetylation	TEPTPAQKTPAKVVY CCCCCCCCCCCEEEE	59.59	25953088
172	Phosphorylation	EPTPAQKTPAKVVYV CCCCCCCCCCEEEEE	19.19	26055452
181	Phosphorylation	AKVVYVFSTEMANKA CEEEEEEEHHHHHHH	17.26	27251275
225	Phosphorylation	APLNTQISALRNDPK CCHHHHHHHHHCCCC	16.07	28555341
232	Acetylation	SALRNDPKPLPQQPP HHHHCCCCCCCCCCC	63.15	23236377
248	Phosphorylation	PANQDQNSSQNTRLQ CCCCCCCCCCCCCCC	27.89	27732954
249	Phosphorylation	ANQDQNSSQNTRLQP CCCCCCCCCCCCCCC	34.69	27732954
252	Phosphorylation	DQNSSQNTRLQPTPP CCCCCCCCCCCCCCC	25.72	27732954
257	Phosphorylation	QNTRLQPTPPIPAPA CCCCCCCCCCCCCCC	28.83	30266825
278	Phosphorylation	PRPLDRESPGVENKL CCCCCCCCCCCCCCC	28.04	23401153
288	Phosphorylation	VENKLIPSVGSPASS CCCCCCCCCCCCCCC	31.92	30266825
291	Phosphorylation	KLIPSVGSPASSTPL CCCCCCCCCCCCCCC	18.35	30266825
294	Phosphorylation	PSVGSPASSTPLPPD CCCCCCCCCCCCCCC	37.82	30266825
295	Phosphorylation	SVGSPASSTPLPPDG CCCCCCCCCCCCCCC	35.83	30266825
296	Phosphorylation	VGSPASSTPLPPDGT CCCCCCCCCCCCCCC	26.75	30266825
303	Phosphorylation	TPLPPDGTGPNSTPN CCCCCCCCCCCCCCC	57.77	20068231
307	Phosphorylation	PDGTGPNSTPNNRAV CCCCCCCCCCCCCCC	48.66	20068231
308	Phosphorylation	DGTGPNSTPNNRAVT CCCCCCCCCCCCCCC	36.35	20068231
315	Phosphorylation	TPNNRAVTPVSQGSN CCCCCCCCCCCCCCC	19.58	19664994
318	O-linked_Glycosylation	NRAVTPVSQGSNSSS CCCCCCCCCCCCCCC	29.99	30379171
318	Phosphorylation	NRAVTPVSQGSNSSS CCCCCCCCCCCCCCC	29.99	17525332
321	Phosphorylation	VTPVSQGSNSSSADP CCCCCCCCCCCCCCC	26.38	20363803
323	Phosphorylation	PVSQGSNSSSADPKA CCCCCCCCCCCCCCC	27.63	23403867
324	Phosphorylation	VSQGSNSSSADPKAP CCCCCCCCCCCCCCC	33.52	23403867
325	Phosphorylation	SQGSNSSSADPKAPP CCCCCCCCCCCCCCC	36.19	23403867
338	Phosphorylation	PPPPPVSSGEPPTLG CCCCCCCCCCCCCCC	47.62	28555341
352	Phosphorylation	GENPDGLSQEQLEHR CCCCCCCCHHHHHHH	36.88	22817900
362	Phosphorylation	QLEHRERSLQTLRDI HHHHHHHHHHHHHHH	21.78	20068231
415	Phosphorylation	AMMAQSQSLGKGPGP HHHHHHHHCCCCCCC	44.32	28555341
418	Acetylation	AQSQSLGKGPGPRTD HHHHHCCCCCCCCCC	68.19	25953088
441	Phosphorylation	GHRDVPFSPDEMVPP CCCCCCCCHHHCCCC	25.93	22210691
543	Phosphorylation	DGINMPHSLPPRGMA CCCCCCCCCCCCCCC	36.38	24719451
613	Phosphorylation	PPGQGIFSGPGRGER CCCCCCCCCCCCCCC	42.00	-
620	Dimethylation	SGPGRGERFPNPQGL CCCCCCCCCCCCCCC	55.96	-
655	Phosphorylation	AMEGIRPSMEMNRMI HHCCCCCHHHHHHCC	19.95	30631047
687	Phosphorylation	IPVEGPLSPSRGDFP CCCCCCCCCCCCCCC	24.78	19664994
689	Phosphorylation	VEGPLSPSRGDFPKG CCCCCCCCCCCCCCC	45.58	30278072
714	Phosphorylation	LEFGMVPSGMKGDVN EEEEECCCCCCCCEE	39.86	24425749
788	Phosphorylation	PRPFLPMSQGPGSNS CCCCCCCCCCCCCCC	30.00	24719451
793	Phosphorylation	PMSQGPGSNSGLRNL CCCCCCCCCCHHCCC	30.84	24719451
795	Phosphorylation	SQGPGSNSGLRNLRE CCCCCCCCHHCCCCC	40.68	26270265
801	Asymmetric dimethylarginine	NSGLRNLREPIGPDQ CCHHCCCCCCCCCCC	51.71	-
801	Methylation	NSGLRNLREPIGPDQ CCHHCCCCCCCCCCC	51.71	-
844	Acetylation	VQRGLGRKPLDISVA CCCCCCCCCCEEEEE	48.40	23954790
849	Phosphorylation	GRKPLDISVAGSQVH CCCCCEEEEECCCCC	12.94	23186163
853	Phosphorylation	LDISVAGSQVHSPGI CEEEEECCCCCCCCC	21.20	23186163
857	Phosphorylation	VAGSQVHSPGINPLK EECCCCCCCCCCCCC	26.43	22617229
865	Phosphorylation	PGINPLKSPTMHQVQ CCCCCCCCCCCCCCC	33.03	20363803
867	Phosphorylation	INPLKSPTMHQVQSP CCCCCCCCCCCCCCC	34.08	25159151
873	Phosphorylation	PTMHQVQSPMLGSPS CCCCCCCCCCCCCCC	17.27	20363803
878	Phosphorylation	VQSPMLGSPSGNLKS CCCCCCCCCCCCCCC	16.36	20363803
880	Phosphorylation	SPMLGSPSGNLKSPQ CCCCCCCCCCCCCCC	41.85	27732954
885	Phosphorylation	SPSGNLKSPQTPSQL CCCCCCCCCCCHHHH	25.96	20363803
888	Phosphorylation	GNLKSPQTPSQLAGM CCCCCCCCHHHHHHH	28.43	27732954
890	Phosphorylation	LKSPQTPSQLAGMLA CCCCCCHHHHHHHHH	41.01	20363803
904	Phosphorylation	AGPAAAASIKSPPVL HCHHHHHHCCCCCCC	26.31	28348404
907	Phosphorylation	AAAASIKSPPVLGSA HHHHHCCCCCCCCCC	32.53	25159151
913	Phosphorylation	KSPPVLGSAAASPVH CCCCCCCCCCCCCCC	15.58	25159151
917	Phosphorylation	VLGSAAASPVHLKSP CCCCCCCCCCCCCCC	23.80	30266825
923	Phosphorylation	ASPVHLKSPSLPAPS CCCCCCCCCCCCCCC	26.53	24719451
925	Phosphorylation	PVHLKSPSLPAPSPG CCCCCCCCCCCCCCC	54.82	24719451
930	Phosphorylation	SPSLPAPSPGWTSSP CCCCCCCCCCCCCCC	37.84	28348404
934	Phosphorylation	PAPSPGWTSSPKPPL CCCCCCCCCCCCCCC	25.83	28348404
935	Phosphorylation	APSPGWTSSPKPPLQ CCCCCCCCCCCCCCC	37.83	28348404
936	Phosphorylation	PSPGWTSSPKPPLQS CCCCCCCCCCCCCCC	29.57	28348404
943	Phosphorylation	SPKPPLQSPGIPPNH CCCCCCCCCCCCCCC	32.54	28348404
1015	Acetylation	IMMSRMSKFAMPSST HHHHHHHHHCCCCCC	28.00	25953088
1020	Phosphorylation	MSKFAMPSSTPLYHD HHHHCCCCCCCCCHH	33.49	28555341
1022	Phosphorylation	KFAMPSSTPLYHDAI HHCCCCCCCCCHHHH	22.96	28555341
1031	Phosphorylation	LYHDAIKTVASSDDD CCHHHHHHHHCCCCC	18.39	29978859
1034	Phosphorylation	DAIKTVASSDDDSPP HHHHHHHCCCCCCCC	29.93	29978859
1035	Phosphorylation	AIKTVASSDDDSPPA HHHHHHCCCCCCCCC	35.01	29978859
1039	Phosphorylation	VASSDDDSPPARSPN HHCCCCCCCCCCCCC	39.51	23911959
1044	Phosphorylation	DDSPPARSPNLPSMN CCCCCCCCCCCCCCC	21.90	29255136
1049	Phosphorylation	ARSPNLPSMNNMPGM CCCCCCCCCCCCCCC	36.99	29255136
1060	Phosphorylation	MPGMGINTQNPRISG CCCCCCCCCCCCCCC	28.01	29978859
1164	Phosphorylation	GPSGGQGSFPGGMGF CCCCCCCCCCCCCCC	22.00	28787133
1244	Acetylation	SRIIPSEKPSQTLQY HHCCCCCCCCCCCCC	55.07	23749302
1254	Methylation	QTLQYFPRGEVPGRK CCCCCCCCCCCCCCC	43.96	-
1335	Phosphorylation	GPHHRMMSPAQSTMP CCCCCCCCHHHHCCC	14.03	28674151
1346	Phosphorylation	STMPGQPTLMSNPAA HCCCCCCCCCCCCCC	27.49	28674151
1415	Phosphorylation	DVGMGGFSQGPGNPG CCCCCCCCCCCCCCC	37.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
172	T	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BCL9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BCL9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CTNB1_HUMAN	CTNNB1	physical	24360964

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BCL9_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104 AND THR-315, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; THR-308; THR-315;SER-318; SER-687 AND SER-689, AND MASS SPECTROMETRY.	19413330 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-315 AND SER-687, ANDMASS SPECTROMETRY.	15302935 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-155 AND THR-172, ANDMASS SPECTROMETRY.	18669648 [Abstract]