BCL9L_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BCL9L_MOUSE
• UniProt AC: Q67FY2
• Protein Name: B-cell CLL/lymphoma 9-like protein
• Gene Name: Bcl9l
• Organism: Mus musculus (Mouse).
• Sequence Length: 1494
• Subcellular Localization: Nucleus . localized also in punctate nuclear bodies as well in the cytoplasm. Colocalizes with CTNNB1.
• Protein Description: Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1..
• Protein Sequence: MRILANKTRLPHPRRREAPGSPPLSPRGHCPPAPAKPMHPENKLTNHGKTGNGGAQSQHQNVNQGPTCNLGSKGVGAGSHGAKANQISPSNSSLKNPQAGVSPFSSLKGKVKRERSVSVDSGEQREAGTPSLDSEAKEVAPRSKRRCVLERKQPYSGDEWCSGPDSEEDDKPIAAAHNCNVADPAMVTPQLGPGQTAQLPLSESSAPGPQHGPQPGLRPDVPGGGGGGVPGKPPSQFVYVFTTHLANTAAEAVLQGRAESILAYHQQNVPRAKLDQAPKVPPTPEPLPLNTPSAGTPQSQPPPLPPPPPAPGSAPPALPPEGPPEDTSQDLAPNSVGAASTGGGTGGTHPNTPTAATANNPLPPGGDPGSAPGSALLGEATPTGNGQRNLVGSEGLSKEQLEHRERSLQTLRDIERLLLRSGETEPFLKGPPGGAGEGGPPAQAPSAAQPPPSAPPGGLKKYEEPLQSMISQTQSLGGPPLEHEVPGHPQGGDMGQQMNMMMQRLGQDSLTPEQVAWRKLQEEYYEEKRRKEEQIGLHGGRPLQDMVGMGGMMGRGPPPPYHSKPGDQWPPGMGAQLRGPMDVQDPMQLRPGPPFPGPRFPGNQMQRVPGFGGMQSMPMEVPMNAMQRPVRPGMAWNEDLPPIGGPSNFAQNAVPYPGGQGEAERFMTPRVREELLRHQLLEKRSMGMQRPLGMAGSGMGQSMEMERMIQAHRQMDPAMFPGQMTGGDGLAGTPMGIEFGGGRGLLSPPMGQSGLREVDPPMGPGNLNMNMNVNMNMNMNLNVQMTPQQQMLMSQKMRGPGDMMGPQGLSPEEMARVRAQNSSGMMGGPQKMLMPSQFPNQGQQGFSGGQGPYQAMPQDMGNTPDMFSPDQSSVPMGTVGTARLSHMPLPPASNPPGSVHLASNRGLGRRPSDLTISINQMGSPGMGHLKSPTLSQVHSPLVTSPSANLKSPQTPSQMVPLPSANPPGPLKSPQVLSSSLGVRSPTGSPSRLKSPSMAVPSPGWVASPKTAMPSPGVSQNKQPPLSINSSSTLGNVEQGALPPSAPRNSSSAPPANPSSGLMNPSLPFTSSPDPTPSQNPLSLMMSQMSKYAMPSSTPLYHNAIKTIATSDDELLPDRPLLPPPPPPQGSGPGISNNQPNQMHMNPAAAQSPMGMNLPGQQPLSHEPPPTMLPSPTPLGSNIPLHPNAQGTGGSSQNSMMMAPGGPDSLNAPCGPVPSSSQMMSFPPRLQQPHGAMAPTGAGGPGLQQHYPSGMALPPEDLPTQPPGPIPPQQHLMGKGMTGRMGDAYPPGVLPGVASVLNDPELSEVIRPTPTGIPEFDLSRIIPSEKPSSTLQYFPKSENQPPKAQPPNLHLMNLQNMMAEQTPSRPPNLPGQQGVQRGLSMSMCHPGQMSLLGRTGVPPQQGMVPHGLHQGVMSPPQGLMTQQNFMLMKQRGVGGEVYTQPPHMLSPQGSLMGPPPQQNLMVSHPLRQRSVSLDSQMGYLPTPGSMANLPF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Dimethylation	------MRILANKTR ------CCCCCCCCC	43.88	-
21	Phosphorylation	RRREAPGSPPLSPRG CCCCCCCCCCCCCCC	23.45	25521595
25	Phosphorylation	APGSPPLSPRGHCPP CCCCCCCCCCCCCCC	20.51	25521595
36	Acetylation	HCPPAPAKPMHPENK CCCCCCCCCCCCCCC	41.64	23806337
49	Acetylation	NKLTNHGKTGNGGAQ CCCCCCCCCCCCCCC	45.79	7492037
73	Acetylation	PTCNLGSKGVGAGSH CCCCCCCCCCCCCCC	56.68	7492047
88	Phosphorylation	GAKANQISPSNSSLK CCCCCCCCCCCCCCC	16.71	25521595
90	Phosphorylation	KANQISPSNSSLKNP CCCCCCCCCCCCCCC	42.42	29472430
92	Phosphorylation	NQISPSNSSLKNPQA CCCCCCCCCCCCCCC	41.19	29472430
93	Phosphorylation	QISPSNSSLKNPQAG CCCCCCCCCCCCCCC	47.84	28066266
102	Phosphorylation	KNPQAGVSPFSSLKG CCCCCCCCCCHHHCC	21.22	25521595
105	Phosphorylation	QAGVSPFSSLKGKVK CCCCCCCHHHCCCCC	37.84	26643407
106	Phosphorylation	AGVSPFSSLKGKVKR CCCCCCHHHCCCCCE	34.18	26643407
108	Acetylation	VSPFSSLKGKVKRER CCCCHHHCCCCCEEE	59.64	23806337
110	Acetylation	PFSSLKGKVKRERSV CCHHHCCCCCEEEEE	42.89	23806337
112	Acetylation	SSLKGKVKRERSVSV HHHCCCCCEEEEEEC	52.61	30985497
116	Phosphorylation	GKVKRERSVSVDSGE CCCCEEEEEECCCCC	17.62	25521595
118	Phosphorylation	VKRERSVSVDSGEQR CCEEEEEECCCCCCC	22.81	25521595
121	Phosphorylation	ERSVSVDSGEQREAG EEEEECCCCCCCCCC	41.91	25521595
129	Phosphorylation	GEQREAGTPSLDSEA CCCCCCCCCCCCHHH	19.42	25521595
131	Phosphorylation	QREAGTPSLDSEAKE CCCCCCCCCCHHHHH	44.65	26160508
134	Phosphorylation	AGTPSLDSEAKEVAP CCCCCCCHHHHHHCC	44.76	29472430
137	Acetylation	PSLDSEAKEVAPRSK CCCCHHHHHHCCHHH	48.98	23806337
143	Phosphorylation	AKEVAPRSKRRCVLE HHHHCCHHHCCEEEE	29.47	28059163
421	Phosphorylation	IERLLLRSGETEPFL HHHHHHHCCCCCCCC	40.73	-
509	Phosphorylation	MQRLGQDSLTPEQVA HHHHCCCCCCHHHHH	26.67	28066266
511	Phosphorylation	RLGQDSLTPEQVAWR HHCCCCCCHHHHHHH	28.82	28066266
531	Ubiquitination	YYEEKRRKEEQIGLH HHHHHHHHHHHCCCC	70.41	-
672	Dimethylation	RFMTPRVREELLRHQ HHCCHHHHHHHHHHH	32.71	-
677	Asymmetric dimethylarginine	RVREELLRHQLLEKR HHHHHHHHHHHHHHH	28.29	-
677	Methylation	RVREELLRHQLLEKR HHHHHHHHHHHHHHH	28.29	24129315
685	Phosphorylation	HQLLEKRSMGMQRPL HHHHHHHCCCCCCCC	30.65	28059163
702	Phosphorylation	AGSGMGQSMEMERMI CCCCHHHHHHHHHHH	15.81	28059163
747	Phosphorylation	GGGRGLLSPPMGQSG CCCCCCCCCCCCCCC	31.81	25521595
750	Oxidation	RGLLSPPMGQSGLRE CCCCCCCCCCCCCCC	9.65	17242355
753	Phosphorylation	LSPPMGQSGLREVDP CCCCCCCCCCCCCCC	33.78	28833060
810	Phosphorylation	MMGPQGLSPEEMARV CCCCCCCCHHHHHHH	36.77	26643407
912	Phosphorylation	RGLGRRPSDLTISIN CCCCCCCHHCEEEEE	43.36	26824392
915	Phosphorylation	GRRPSDLTISINQMG CCCCHHCEEEEECCC	20.05	28833060
917	Phosphorylation	RPSDLTISINQMGSP CCHHCEEEEECCCCC	15.39	28833060
923	Phosphorylation	ISINQMGSPGMGHLK EEEECCCCCCCCCCC	16.97	28833060
931	Phosphorylation	PGMGHLKSPTLSQVH CCCCCCCCCCHHHCC	29.49	27087446
933	Phosphorylation	MGHLKSPTLSQVHSP CCCCCCCCHHHCCCC	46.24	26824392
935	Phosphorylation	HLKSPTLSQVHSPLV CCCCCCHHHCCCCCC	32.41	23737553
939	Phosphorylation	PTLSQVHSPLVTSPS CCHHHCCCCCCCCCC	22.52	27087446
943	Phosphorylation	QVHSPLVTSPSANLK HCCCCCCCCCCCCCC	42.47	27087446
944	Phosphorylation	VHSPLVTSPSANLKS CCCCCCCCCCCCCCC	14.91	27087446
946	Phosphorylation	SPLVTSPSANLKSPQ CCCCCCCCCCCCCCC	29.56	25168779
951	Phosphorylation	SPSANLKSPQTPSQM CCCCCCCCCCCHHHC	25.96	24899341
954	Phosphorylation	ANLKSPQTPSQMVPL CCCCCCCCHHHCCCC	28.43	24899341
956	Phosphorylation	LKSPQTPSQMVPLPS CCCCCCHHHCCCCCC	34.00	22817900
963	Phosphorylation	SQMVPLPSANPPGPL HHCCCCCCCCCCCCC	48.65	19854140
972	Phosphorylation	NPPGPLKSPQVLSSS CCCCCCCCHHHHHHH	28.40	27087446
977	Phosphorylation	LKSPQVLSSSLGVRS CCCHHHHHHHCCCCC	21.01	26160508
978	Phosphorylation	KSPQVLSSSLGVRSP CCHHHHHHHCCCCCC	25.97	25168779
979	Phosphorylation	SPQVLSSSLGVRSPT CHHHHHHHCCCCCCC	26.26	26160508
984	Phosphorylation	SSSLGVRSPTGSPSR HHHCCCCCCCCCHHH	25.14	27818261
986	Phosphorylation	SLGVRSPTGSPSRLK HCCCCCCCCCHHHCC	52.09	27087446
988	Phosphorylation	GVRSPTGSPSRLKSP CCCCCCCCHHHCCCC	23.37	27087446
990	Phosphorylation	RSPTGSPSRLKSPSM CCCCCCHHHCCCCCC	52.52	26160508
994	Phosphorylation	GSPSRLKSPSMAVPS CCHHHCCCCCCCCCC	27.14	25521595
996	Phosphorylation	PSRLKSPSMAVPSPG HHHCCCCCCCCCCCC	26.85	23684622
997	Oxidation	SRLKSPSMAVPSPGW HHCCCCCCCCCCCCC	5.04	17242355
1001	Phosphorylation	SPSMAVPSPGWVASP CCCCCCCCCCCCCCC	29.46	27087446
1007	Phosphorylation	PSPGWVASPKTAMPS CCCCCCCCCCCCCCC	19.81	25521595
1010	Phosphorylation	GWVASPKTAMPSPGV CCCCCCCCCCCCCCC	31.41	25619855
1014	Phosphorylation	SPKTAMPSPGVSQNK CCCCCCCCCCCCCCC	22.62	25521595
1018	Phosphorylation	AMPSPGVSQNKQPPL CCCCCCCCCCCCCCC	33.67	25619855
1071	Phosphorylation	PSLPFTSSPDPTPSQ CCCCCCCCCCCCCCC	30.20	24453211
1224	Phosphorylation	PSSSQMMSFPPRLQQ CCHHHHHCCCCCCCC	29.29	25159016
1329	Acetylation	SRIIPSEKPSSTLQY HHCCCCCCCCCCCCC	55.31	23806337
1383	Phosphorylation	QGVQRGLSMSMCHPG HHHHHCCCHHHCCCC	16.19	24719451
1417	Phosphorylation	GLHQGVMSPPQGLMT CCCCCCCCCCCCCCH	30.90	-
1473	Phosphorylation	SHPLRQRSVSLDSQM CCCCCCCCCCCCCCC	14.02	28833060
1475	Phosphorylation	PLRQRSVSLDSQMGY CCCCCCCCCCCCCCC	27.92	28833060
1478	Phosphorylation	QRSVSLDSQMGYLPT CCCCCCCCCCCCCCC	27.62	28833060
1482	Phosphorylation	SLDSQMGYLPTPGSM CCCCCCCCCCCCCCC	12.26	28833060
1485	Phosphorylation	SQMGYLPTPGSMANL CCCCCCCCCCCCCCC	37.37	28833060
1488	Phosphorylation	GYLPTPGSMANLPF- CCCCCCCCCCCCCC-	18.87	28833060

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BCL9L_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BCL9L_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BCL9L_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BCL9L_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-984; SER-994; SER-1001AND SER-1007, AND MASS SPECTROMETRY.
PubMed: 17242355