BCAP_MOUSE - dbPTM
BCAP_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BCAP_MOUSE
UniProt AC Q9EQ32
Protein Name Phosphoinositide 3-kinase adapter protein 1
Gene Name Pik3ap1
Organism Mus musculus (Mouse).
Sequence Length 811
Subcellular Localization Cytoplasm . Cell membrane
Peripheral membrane protein .
Protein Description Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL..
Protein Sequence MAASGWGRGCDILIFYSPDAEEWCQYLQDLFVSCRQVRSQKTQTYRLVPDASFSAQDLWVFRDARCVLVLLSAGLVGCFGQPGLLPMLQRACHPPQRVVRLLCGVQPGDEDFQAFFPDWAHWQEMTCDDEPETYLAAVRKAISEDSGCDSVTDTEPEDERELPFSKQTNLPPEISPGNLMVVQPDRIRCGAETTVYIIVRCKLDEKVSTEAEFSPEDSPSIRVEGTLENEYTVSVKAPDLSSGNVSLKVYSGDLVVCETTVSYYTDMEEIGNLLSSAANPVEFMCQAFKIVPYNTETLDKLLTESLKNNIPASGLHLFGINQLEEDDMMTNQRDEELPTLLHFAAKYGLKNLTALLLTCPGALQAYSVANKHGHYPNTIAEKHGFRDLRQFIDEYVETVDMLKTHIKEELMQGEEADDVYESMAHLSTDLLMKCSLNPGCDDELYESMAAFAPAATEDLYVEMLQASAGNPVSGESFSRPTKDSMIRKFLEGNSVKPASWEREQHHPYGEELYHIVDEDETFSVDLANRPPVPVPRPEASAPGPPPPPDNEPYISKVFAEKSQERLGNFYVSSESIRKEPLVRPWRDRPPSSIYDPFAGMKTPGQRQLITLQEQVKLGIVNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRESITRRRKEKPKSGKHTDLEITVPIRHSQHLPEKVEFGVYESGPRKSVLPARTELRRGDWKTDSMSSTASSTSNRSSTRSLLSVSSGMEGDNEDNEIPEITRSRGPGPTQVDGAPVVTGTPVGTLERPPRVPPRAASQRPLTRESFHPPPPVPPRGR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
143PhosphorylationAAVRKAISEDSGCDS
HHHHHHHHCCCCCCC		39.9630635358
146PhosphorylationRKAISEDSGCDSVTD
HHHHHCCCCCCCCCC		36.9525521595
150PhosphorylationSEDSGCDSVTDTEPE
HCCCCCCCCCCCCCC		30.8725521595
152PhosphorylationDSGCDSVTDTEPEDE
CCCCCCCCCCCCCCC		40.9525521595
154PhosphorylationGCDSVTDTEPEDERE
CCCCCCCCCCCCCCC		44.0425521595
165PhosphorylationDERELPFSKQTNLPP
CCCCCCCCCCCCCCC		23.1630635358
226PhosphorylationPSIRVEGTLENEYTV
CCCEEEEEECCEEEE		19.8630635358
231PhosphorylationEGTLENEYTVSVKAP
EEEECCEEEEEEECC		24.8330635358
232PhosphorylationGTLENEYTVSVKAPD
EEECCEEEEEEECCC		10.5030635358
234PhosphorylationLENEYTVSVKAPDLS
ECCEEEEEEECCCCC		15.3130635358
264PhosphorylationCETTVSYYTDMEEIG
EEEEEEEECCHHHHH		6.6911163197
295PhosphorylationFKIVPYNTETLDKLL
HEEECCCHHHHHHHH		25.2228285833
403UbiquitinationVETVDMLKTHIKEEL
HHHHHHHHHHHHHHH		31.2722790023
420PhosphorylationGEEADDVYESMAHLS
CCCHHHHHHHHHHHC		14.8511163197
445PhosphorylationPGCDDELYESMAAFA
CCCCHHHHHHHHHHC		12.1511163197
460PhosphorylationPAATEDLYVEMLQAS
CCCCHHHHHHHHHHH		13.4911163197
488UbiquitinationTKDSMIRKFLEGNSV
CCHHHHHHHHCCCCC		43.2922790023
494PhosphorylationRKFLEGNSVKPASWE
HHHHCCCCCCCCCCC		42.2320139300
496UbiquitinationFLEGNSVKPASWERE
HHCCCCCCCCCCCCC		34.3922790023
499PhosphorylationGNSVKPASWEREQHH
CCCCCCCCCCCCCCC		37.6929472430
513PhosphorylationHPYGEELYHIVDEDE
CCCCCCCEEEECCCC		7.87-
553PhosphorylationPPPDNEPYISKVFAE
CCCCCCCCHHHHHHH		16.20-
561UbiquitinationISKVFAEKSQERLGN
HHHHHHHHHHHHHCC		54.7522790023
562PhosphorylationSKVFAEKSQERLGNF
HHHHHHHHHHHHCCC		28.8724719451
570PhosphorylationQERLGNFYVSSESIR
HHHHCCCEECCHHHC		11.9225159016
572PhosphorylationRLGNFYVSSESIRKE
HHCCCEECCHHHCCC		19.6025367039
573PhosphorylationLGNFYVSSESIRKEP
HCCCEECCHHHCCCC		25.8925367039
575PhosphorylationNFYVSSESIRKEPLV
CCEECCHHHCCCCCC		29.6425367039
591PhosphorylationPWRDRPPSSIYDPFA
CCCCCCCCCCCCCCC		31.8625521595
592PhosphorylationWRDRPPSSIYDPFAG
CCCCCCCCCCCCCCC		30.8325266776
594PhosphorylationDRPPSSIYDPFAGMK
CCCCCCCCCCCCCCC		21.3625195567
601UbiquitinationYDPFAGMKTPGQRQL
CCCCCCCCCCCCCEE		51.1322790023
640PhosphorylationQLNQKKRSESFRFQQ
HCCCCHHCHHHHHHH		46.6125266776
642PhosphorylationNQKKRSESFRFQQEN
CCCHHCHHHHHHHHH		23.9825521595
656PhosphorylationNLKRLRESITRRRKE
HHHHHHHHHHHHHHC		23.8722942356
658PhosphorylationKRLRESITRRRKEKP
HHHHHHHHHHHHCCC		27.6625266776
682PhosphorylationITVPIRHSQHLPEKV
EEEECCCCCCCCCCE		14.9429899451
694PhosphorylationEKVEFGVYESGPRKS
CCEEEEEECCCCCCC		12.5419605366
696PhosphorylationVEFGVYESGPRKSVL
EEEEEECCCCCCCCC		36.0925159016
716PhosphorylationLRRGDWKTDSMSSTA
HHCCCCCCCCCCCCC		29.1123984901
718PhosphorylationRGDWKTDSMSSTASS
CCCCCCCCCCCCCCC		26.2924719451
720PhosphorylationDWKTDSMSSTASSTS
CCCCCCCCCCCCCCC		28.6123984901
721PhosphorylationWKTDSMSSTASSTSN
CCCCCCCCCCCCCCC		21.2523984901
722PhosphorylationKTDSMSSTASSTSNR
CCCCCCCCCCCCCCC		24.2123984901
724PhosphorylationDSMSSTASSTSNRSS
CCCCCCCCCCCCCHH		33.9523984901
725PhosphorylationSMSSTASSTSNRSST
CCCCCCCCCCCCHHC		33.1323984901
726PhosphorylationMSSTASSTSNRSSTR
CCCCCCCCCCCHHCC		27.7623984901
727PhosphorylationSSTASSTSNRSSTRS
CCCCCCCCCCHHCCC		31.9923984901
730PhosphorylationASSTSNRSSTRSLLS
CCCCCCCHHCCCEEE		40.0724719451
731PhosphorylationSSTSNRSSTRSLLSV
CCCCCCHHCCCEEEC		25.3025266776
732PhosphorylationSTSNRSSTRSLLSVS
CCCCCHHCCCEEECC		26.0623984901
734PhosphorylationSNRSSTRSLLSVSSG
CCCHHCCCEEECCCC		33.4827087446
737PhosphorylationSSTRSLLSVSSGMEG
HHCCCEEECCCCCCC		25.8327087446
739PhosphorylationTRSLLSVSSGMEGDN
CCCEEECCCCCCCCC		20.1430635358
740PhosphorylationRSLLSVSSGMEGDNE
CCEEECCCCCCCCCC		39.7524719451
755PhosphorylationDNEIPEITRSRGPGP
CCCCCHHHCCCCCCC		22.4130635358
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
420YPhosphorylationKinaseSYKP48025
Uniprot
445YPhosphorylationKinaseSYKP48025
Uniprot
460YPhosphorylationKinaseSYKP48025
Uniprot
513YPhosphorylationKinaseABL1P00520
Uniprot
553YPhosphorylationKinaseABL1P00520
Uniprot
570YPhosphorylationKinaseABL1P00520
Uniprot
594YPhosphorylationKinaseABL1P00520
Uniprot
694YPhosphorylationKinaseABL1P00520
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BCAP_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BCAP_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of BCAP_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BCAP_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Regulation of B-cell development by BCAP and CD19 through theirbinding to phosphoinositide 3-kinase.";
Aiba Y., Kameyama M., Yamazaki T., Tedder T.F., Kurosaki T.;
Blood 111:1497-1503(2008).
Cited for: FUNCTION, INTERACTION WITH PIK3R1, PHOSPHORYLATION AT TYR-264;TYR-420; TYR-445 AND TYR-460, MUTAGENESIS OF TYR-264; TYR-420; TYR-445AND TYR-460, AND DISRUPTION PHENOTYPE.
"BCAP: the tyrosine kinase substrate that connects B cell receptor tophosphoinositide 3-kinase activation.";
Okada T., Maeda A., Iwamatsu A., Gotoh K., Kurosaki T.;
Immunity 13:817-827(2000).
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY,INTERACTION WITH PIK3R1, AND PHOSPHORYLATION AT TYR-264; TYR-420;TYR-445 AND TYR-460.

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