BCAP_CHICK - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BCAP_CHICK
• UniProt AC: Q9DDT2
• Protein Name: Phosphoinositide 3-kinase adapter protein 1
• Gene Name: PIK3AP1
• Organism: Gallus gallus (Chicken).
• Sequence Length: 800
• Subcellular Localization: Cytoplasm . Cell membrane ; Peripheral membrane protein .
• Protein Description: Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL..
• Protein Sequence: MTASGTHGGYDVLILYASDAAEWCQYLQNLFLSTRHIRKHHIQSYQLEGESAISDQELDLFNRSRSIIILLSAELVQNFYCPPVLQSLQEALWPPHKVVKLFCGVTDCDDYLTFFKDWYQWQELTYDDEPDAYLEAVKKAISEDSGCDSVTDTETEDEKTSVYSCQLAMNEEHESSKSTGEHLVVQPDHIRCGVQTTVYIIMKCRLDDKVKTEVEFSPENSSSVRVLAELENEYTISVEAPNLTSGTVPLQIYSGDLMVGETSVTYHTDMEEISSLLANAANPVQFMCQAFKIVPYSIEALDKLLTESLKKNIPASGLHLFGINQLEEDDMTTNQRDEELPTLLHFSARYGLKNLTALLLTCPGALQAYSVANKYGHYPNTIAEKHGFKDLRQFIDEYVETADMLKSHIKEELMQGEEDESVYESMAHLSTDLLMKCSLNPGSDEELYESMAGFVPGAPEDLYVEMLQSKPDTPISGDEISLTVKDSMLRKFLEGGSTDAPDSGEGVSQQYGEDLYYSVEKDTFPQEMASRPPVPVPRPESSSPQPDNELYISKVFAQKAQRPENLYVPRGKVRKETIVRPVRDLSQSSIYDPFAGMKTPGQRQLITLQEQVKMGILNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRDSITRRQMEKQKSGKSADLEITVPIRRSHNTLGKPECGIYEYAPRKNIFPPKKELKRGDWKTESTSSTTSSASNRSSTRSILSVSSGMEGDSEDNEVSEASRSRSPIPSQAERLPLPLPERPPRVPPRGASRPVNCEGFYPPPVPPRGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
199	Phosphorylation	CGVQTTVYIIMKCRL ECCEEEEEEEEECCC	5.22	-
266	Phosphorylation	VGETSVTYHTDMEEI EEEEEEEEECCHHHH	10.68	11163197
423	Phosphorylation	GEEDESVYESMAHLS CCCCHHHHHHHHHHC	16.15	11163197
448	Phosphorylation	PGSDEELYESMAGFV CCCHHHHHHHHCCCC	14.83	11163197
463	Phosphorylation	PGAPEDLYVEMLQSK CCCCHHHHHHHHHCC	13.49	11163197

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
423	Y	Phosphorylation	Kinase	SYK	F1N9Y5	Uniprot
448	Y	Phosphorylation	Kinase	SYK	F1N9Y5	Uniprot
463	Y	Phosphorylation	Kinase	SYK	F1N9Y5	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BCAP_CHICK !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BCAP_CHICK !!

Protein-Protein Interaction

Oops, there are no PPI records of BCAP_CHICK !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"BCAP: the tyrosine kinase substrate that connects B cell receptor tophosphoinositide 3-kinase activation.";
Okada T., Maeda A., Iwamatsu A., Gotoh K., Kurosaki T.;
Immunity 13:817-827(2000).
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF293-303; 492-505; 560-566; 599-612 AND 614-624, FUNCTION, SUBCELLULARLOCATION, INTERACTION WITH PIK3R1, PHOSPHORYLATION AT TYR-266;TYR-423; TYR-448 AND TYR-463, AND MUTAGENESIS OF TYR-266; TYR-423;TYR-448 AND TYR-463.
PubMed: 11163197