| UniProt ID | BBOF1_HUMAN | |
|---|---|---|
| UniProt AC | Q8ND07 | |
| Protein Name | Basal body-orientation factor 1 {ECO:0000312|HGNC:HGNC:19855} | |
| Gene Name | BBOF1 {ECO:0000312|HGNC:HGNC:19855} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 529 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, cilium basal body. Localizes to a polar structure adjacent to the basal body.. | |
| Protein Description | Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity).. | |
| Protein Sequence | MPSKGKDKKKGKSKGKDTKKLIKTDESVVDRAKANASLWEARLEVTELSRIKYRDTSRILAKSNEDLKKKQCKMEKDIMSVLSYLKKQDQEKDNMIEKLKQQLNETKEKAQEEKDKLEQKYTRQINELEGQFHQKAKEIGMIHTELKAVRQFQKRKIQVERELDDLKENLRNTERIHQETLRRLESRFFEEKHRLEQEAEKKIIMLAERAHHEAIVQLNDAGRNVFKENDYLQKALAYHLKETDALQKNSQKLQESHTLLLHQKEINDLLVKEKIMQLVQQRSQIQTLQKKVVNLETALSYMTKEFESEVLKLQQHAMIENQAGQVEIDKLQHLLQMKDREMNRVKKLAKNILDERTEVERFFLDALHQVKQQILISRKHYKQIAQAAFNLKMRAACTGRTEYPKIRTFDGREHSTNSVNQDLLEAEKWTHIEGNVDIGDLTWEQKEKVLRLLFAKMNGCPSRKYNQSSRPPVPDYVVSDSGETKEFGDESKLQDKIFITQQIAISDSSGEVVLPTIPKEPQESDTGTF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MPSKGKDKKK -----CCCCCCCCCC | 17081983 | ||
| 4 | Acetylation | ----MPSKGKDKKKG ----CCCCCCCCCCC | 7823245 | ||
| 8 | Acetylation | MPSKGKDKKKGKSKG CCCCCCCCCCCCCCC | 7823255 | ||
| 9 | Acetylation | PSKGKDKKKGKSKGK CCCCCCCCCCCCCCC | 7823265 | ||
| 238 | Phosphorylation | YLQKALAYHLKETDA HHHHHHHHHHHHHHH | - | ||
| 256 | Phosphorylation | NSQKLQESHTLLLHQ HHHHHHHHHHHHHHH | 30622161 | ||
| 258 | Phosphorylation | QKLQESHTLLLHQKE HHHHHHHHHHHHHHH | 30622161 | ||
| 287 | Phosphorylation | QQRSQIQTLQKKVVN HHHHHHHHHHHHHCC | 27067055 | ||
| 500 | Phosphorylation | LQDKIFITQQIAISD HHCEEEEEEEEEEEC | 25693802 | ||
| 506 | Phosphorylation | ITQQIAISDSSGEVV EEEEEEEECCCCCEE | 25693802 | ||
| 508 | Phosphorylation | QQIAISDSSGEVVLP EEEEEECCCCCEEEE | 25693802 | ||
| 509 | Phosphorylation | QIAISDSSGEVVLPT EEEEECCCCCEEEEC | 25693802 | ||
| 516 | Phosphorylation | SGEVVLPTIPKEPQE CCCEEEECCCCCCCC | 20068231 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BBOF1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BBOF1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BBOF1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of BBOF1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
