BBC3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BBC3_MOUSE
• UniProt AC: Q99ML1
• Protein Name: Bcl-2-binding component 3
• Gene Name: Bbc3
• Organism: Mus musculus (Mouse).
• Sequence Length: 193
• Subcellular Localization: Mitochondrion. Localized to the mitochondria in order to induce cytochrome c release..
• Protein Description: Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53 (By similarity). Regulates ER stress-induced neuronal apoptosis..
• Protein Sequence: MARARQEGSSPEPVEGLARDSPRPFPLGRLMPSAVSCSLCEPGLPAAPAAPALLPAAYLCAPTAPPAVTAALGGPRWPGGHRSRPRGPRPDGPQPSLSPAQQHLESPVPSAPEALAGGPTQAAPGVRVEEEEWAREIGAQLRRMADDLNAQYERRRQEEQHRHRPSPWRVMYNLFMGLLPLPRDPGAPEMEPN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	ARARQEGSSPEPVEG CCCCCCCCCCCCCCC	41.80	25266776
10	Phosphorylation	RARQEGSSPEPVEGL CCCCCCCCCCCCCCC	44.11	26824392
21	Phosphorylation	VEGLARDSPRPFPLG CCCCCCCCCCCCCCC	19.77	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BBC3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BBC3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BBC3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BBC3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.