BAG4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BAG4_MOUSE
• UniProt AC: Q8CI61
• Protein Name: BAG family molecular chaperone regulator 4
• Gene Name: Bag4
• Organism: Mus musculus (Mouse).
• Sequence Length: 457
• Subcellular Localization: Cytoplasm.
• Protein Description: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling (By similarity). Negative regulator of PRKN translocation to damaged mitochondria (By similarity)..
• Protein Sequence: MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHVPPPLYPPLRPEPPQPPVSWRGRGGAPAETTWPGEGAGGDGYYPSGGAWAEASRAGGGHQEQPPYPGYNSNYWNSVRPRAPYPGSYSVRPELQGQSLNSYANGAYGPPYPPGPGASTASYSGAYYVPGYTQSNYSTEVPNTYRSPGNSPTPMSRWMYSQQDCPTEAPPLRGQVPGYPASQNPGMTLPHYPYGDGNRAVPQSGGTGRPQDDAWASSAYGMGARYPWPSAAPSAPSAGSLYMTESASPWPGNSSPQPPPSPPPQQPKDPSYSYNPSGQGLSRHSFPCSVHQYESPGAVNNDNSDLLDSQVQYSAEPQLYGNASSEHPSNQVPSNNLPEECFSSDEGTPPSIKKIIHVLEKVQFLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILEKLEKKGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MSALRRSGYGPSDG -CCCCHHCCCCCCCC	29.90	29514104
41	Methylation	PPLYPPLRPEPPQPP CCCCCCCCCCCCCCC	39.03	-
54	Methylation	PPVSWRGRGGAPAET CCCCCCCCCCCCCCC	31.62	24129315
108	Methylation	SNYWNSVRPRAPYPG CCCCCCCCCCCCCCC	18.14	-
172	Phosphorylation	YSTEVPNTYRSPGNS CCCCCCCCCCCCCCC	17.78	23608596
175	Phosphorylation	EVPNTYRSPGNSPTP CCCCCCCCCCCCCCC	27.09	25521595
179	Phosphorylation	TYRSPGNSPTPMSRW CCCCCCCCCCCHHHH	35.75	23684622
181	Phosphorylation	RSPGNSPTPMSRWMY CCCCCCCCCHHHHCC	31.29	25521595
185	Methylation	NSPTPMSRWMYSQQD CCCCCHHHHCCCCCC	18.87	-
283	Phosphorylation	SPWPGNSSPQPPPSP CCCCCCCCCCCCCCC	31.39	23649490
289	Phosphorylation	SSPQPPPSPPPQQPK CCCCCCCCCCCCCCC	56.67	23649490
300	Phosphorylation	QQPKDPSYSYNPSGQ CCCCCCCCCCCCCCC	22.14	28066266
301	Phosphorylation	QPKDPSYSYNPSGQG CCCCCCCCCCCCCCC	23.83	28066266
302	Phosphorylation	PKDPSYSYNPSGQGL CCCCCCCCCCCCCCC	23.90	28066266
305	Phosphorylation	PSYSYNPSGQGLSRH CCCCCCCCCCCCCCC	39.86	28066266
310	Phosphorylation	NPSGQGLSRHSFPCS CCCCCCCCCCCCCCE	34.47	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BAG4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BAG4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BAG4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HS71B_MOUSE	Hspa1b	physical	11527400

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.